The Registry of Toxic Effects of Chemical Substances

Ethane, 1,1,1,2 - tetrachloro -

RTECS #: KI8450000

CAS #: 630-20-6

UPDATE: November 2004 MW: 167.84 MF: C2H2Cl4


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. NCI - C52459
  2. RCRA waste number U208
  1. 1,1,1,2 - Tetrachloroethane


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		100 mg severe AMPMAR 35,593,1974
skin
rabbit 		500 mg/24 hour severe AMPMAR 35,593,1974


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
mutation in microorganisms mouse lymphocyte 200 mg/L (+enzymatic activation step) SCIEAS 236,933,1987
mutation in microorganisms Salmonella typhimurium 10 µg/plate (+/-enzymatic activation step) TECSDY 15,101,1987
gene conversion and mitotic recombination Aspergillus nidulans 250 ppm MUREAV 201,401,1988
mutation in mammalian somatic cells mouse lymphocyte 200 mg/L EMMUEG 12,85,1988
other mutation test systems oral
mouse 		1 gm/kg MUREAV 343,157,1995
sister chromatid exchange hamster ovary 158 mg/L SCIEAS 236,933,1987
sex chromosome loss and nondisjunction Aspergillus nidulans 125 ppm MUREAV 201,401,1988
sex chromosome loss and nondisjunction human lung 100 mg/L MUREAV 369,243,1996


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 128,750 mg/kg/103 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors 		NTIS** PB83-218206
oral
rat 		lowest published toxic dose: 128,750 mg/kg/103 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors 		NTIS** PB83-218206
oral
rat 		lowest published toxic dose: 64,375 mg/kg/103 week- intermittent Tumorigenic: Neoplastic by RTECS criteria

Skin and Appendages: Tumors 		NTIS** PB83-218206


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lethal concentration (50 percent kill): 2,100 ppm/4 hour Gastrointestinal: Hypermotility, diarrhea AMPMAR 35,593,1974
inhalation
rat 		lethal concentration (50 percent kill): 2,100 mg/m3/4 hour N/R VCVGH* -,383,1990
inhalation
rat 		lowest published toxic concentration: 2,000 ppm Lung, Thorax, or Respiration: Cough VCVGH* -,384,1990
inhalation
rat 		lowest published toxic concentration: 3,000 ppm Lung, Thorax, or Respiration: Acute pulmonary edema VCVGH* -,384,1990
inhalation
rat 		lowest published toxic concentration: 4,000 ppm Lung, Thorax, or Respiration: Acute pulmonary edema

Liver: Other changes 		VCVGH* -,384,1990
inhalation
rabbit 		lethal concentration (50 percent kill): 2,800 ppm/4 hour Gastrointestinal: Hypermotility, diarrhea AMPMAR 35,593,1974
inhalation
rabbit 		lethal concentration (50 percent kill): 2,800 mg/m3/4 hour N/R VCVGH* -,383,1990
inhalation
rabbit 		lowest published toxic concentration: 2,000 ppm Lung, Thorax, or Respiration: Acute pulmonary edema

Lung, Thorax, or Respiration: Cough 		VCVGH* -,384,1990
inhalation
rabbit 		lowest published toxic concentration: 2,500 ppm Lung, Thorax, or Respiration: Acute pulmonary edema

Liver: Hepatitis (hepatocellular necrosis), zonal

Blood: Hemorrhage 		VCVGH* -,384,1990
intraperitoneal
mouse 		lethal dose (50 percent kill): 1,275 mg/kg N/R SAIGBL 8,371,1966
oral
guinea pig 		lowest published toxic dose: 600 mg/kg Liver: Hepatitis (hepatocellular necrosis), zonal VCVGH* -,384,1990
oral
mouse 		lethal dose (50 percent kill): 1,500 mg/kg N/R VCVGH* -,383,1990
oral
mouse 		lowest published toxic dose: 1,000 mg/kg Liver: Hepatitis (hepatocellular necrosis), zonal VCVGH* -,384,1990
oral
rat 		lethal dose (50 percent kill): 670 mg/kg N/R VCVGH* -,383,1990
skin
rabbit 		lethal dose (50 percent kill): 20 mg/kg N/R VCVGH* -,383,1990


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lowest published toxic dose: 16 gm/kg/40 day- intermittent Behavioral: Sleep SAIGBL 8,371,1966
intraperitoneal
mouse 		lowest published toxic dose: 2,400 mg/kg/3 day- intermittent Behavioral: Sleep

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		SAIGBL 8,371,1966
oral
mouse 		lowest published toxic dose: 14 gm/kg/14 day- continuous Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field NTPTR* NTP-TR-237,1982
oral
mouse 		lowest published toxic dose: 32,500 mg/kg/13 week- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field NTPTR* NTP-TR-237,1982
oral
rat 		lowest published toxic dose: 7 gm/kg/14 day- continuous Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field NTPTR* NTP-TR-237,1982
oral
rat 		lowest published toxic dose: 128,750 mg/kg/103 week- intermittent Brain and Coverings: Tumors

Tumorigenic: Active as anti-cancer agent 		NTIS** PB83-218206


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
International Agency for Research on Cancer (IARC) Cancer Review Animal Limited Evidence IMEMDT 41,87,1986
International Agency for Research on Cancer (IARC) Cancer Review Animal Limited Evidence IMEMDT 71,1133,1999
International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Data IMEMDT 41,87,1986
International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Data IMEMDT 71,1133,1999
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMEMDT 71,1133,1999
TOXICOLOGY REVIEW
AIHAAP 40(3),A46,1979
TOXICOLOGY REVIEW
MUREAV 543,201,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO 1,1,1,2-TETRACHLOROETHANE-air Handle with caution NIOSH* DHHS #92-100,1992


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a solvent and in manufacture of insecticides, herbicides, soil fumigants and blanches
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH CURRENT INTELLIGENCE BULLETIN 27, 1978
NCI Carcinogenesis Studies (gavage);clear evidence:mouse
NCI Carcinogenesis Studies (gavage);equivocal evidence:rat
NTP Toxicity studies, RPT# TOX-45, October 2000


REFERENCES:

CODEN
REFERENCE
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958-
AMPMAR Archives des Maladies Professionnelles de Medecine du Travail et de Securite Sociale. (SPPIF, B.P.22, F-41353 Vineuil, France) V.7- 1946-
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206-
SAIGBL Sangyo Igaku. Japanese Journal of Industrial Health. (Nippon Sangyo Eisei Igakkai, Kosu Eisei Bldg., 1-29-8, Shinjuku, Shinjuku-ku, Tokyo 160, Japan) V.1- 1959-
SCIEAS Science. (American Assoc. for the Advancement of Science, 1333 H St., NW, Washington, DC 20005) V.1- 1895-
TECSDY Toxicological and Environmental Chemistry. (Gordon & Breach Science Pub. Inc., 1 Park Ave., New York, NY 10016) V.3(3/4)- 1981-
VCVGH* "Vrednie chemichescie veshestva, galogenproisvodnie uglevodorodov". (Hazardous substances: Galogenated hydrocarbons) Bandman A.L. et al., Chimia, 1990.

Used as a solvent and in manufacture of insecticides, herbicides, soil fumigants and blanches

RTECS Compound Description:
   Tumorigen
   Mutagen
   Primary Irritant

 Click Here for Additional Information about RTECS