The Registry of Toxic Effects of Chemical Substances

Ethane, 1,2 - dichloro -

RTECS #: KI0525000

CAS #: 107-06-2

UPDATE: May 2005 MW: 98.96 MF: C2H4Cl2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. TUMORIGENIC DATA:
  6. ACUTE TOXICITY DATA:
  7. OTHER MULTIPLE DOSE DATA:
  8. REVIEWS:
  9. STANDARDS AND REGULATIONS:
  10. NIOSH DOCUMENTATION AND SURVEILLANCE:
  11. STATUS IN FEDERAL AGENCIES:
  12. REFERENCES:

SYNONYMS:

  1. 1,2 - Bichloroethane
  2. 1,2 - DCE
  3. 1,2 - Dichloorethaan (Dutch)
  4. 1,2 - Dichlor - aethan (German)
  5. 1,2 - Dichlorethane
  6. 1,2 - Dichloroethane
  7. 1,2 - Dichloroethane (OSHA)
  8. 1,2 - Dicloroetano (Italian)
  9. 1,2 - Ethylene dichloride
  10. Aethylenchlorid (German)
  11. Bichlorure d'ethylene (French)
  12. Borer sol
  13. Brocide
  14. Chlorure d'ethylene (French)
  15. Cloruro di ethene (Italian)
  16. Destruxol borer - sol
  17. Di - chlor - mulsion
  1. Dichloremulsion
  2. Dichloro - 1,2 - ethane (French)
  3. Dutch liquid
  4. Dutch oil
  5. EDC
  6. ENT 1,656
  7. Ethane dichloride
  8. Ethyleendichloride (Dutch)
  9. Ethylene chloride
  10. Ethylene dichloride
  11. Ethylene dichloride (ACGIH:OSHA)
  12. Glycol dichloride
  13. NCI - C00511
  14. RCRA waste number U077
  15. alpha,beta - Dichloroethane
  16. sym - Dichloroethane


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		63 mg severe UCDS** 3/23/1970
eye
rabbit 		500 mg/24 hour mild 85JCAE -,93,1986
skin
rabbit 		625 mg open irritation test mild UCDS** 3/23/1970
skin
rabbit 		500 mg/24 hour mild 85JCAE -,93,1986


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
body fluid assay mouse
Salmonella typhimurium 		80 mg/kg CBINA8 24,265,1979
cytogenetic analysis hamster lung 1 gm/L ESKHA5 (103),64,1985
cytogenetic analysis oral
mouse 		0.5 ppb EMMUEG 39,69,2002
cytogenetic analysis oral
rat 		0.5 ppb EMMUEG 39,69,2002
DNA damage intraperitoneal
mouse 		2 mmol/kg CRNGDP 4,1491,1983
DNA damage oral
mouse 		100 mg/kg CNREA8 44,4267,1984
DNA damage oral
rat 		150 mg/kg TXAPA9 62,190,1982
DNA damage inhalation
rat 		150 ppm/6 hour TXAPA9 62,190,1982
DNA damage Salmonella typhimurium 7,060 µmol/L TXAPA9 62,190,1982
DNA inhibition human lymphocyte 5 mL/L CALEDQ 13,213,1981
DNA inhibition intraperitoneal
mouse 		29 mg/kg MUREAV 163,193,1986
DNA repair Escherichia coli 10 mg/plate CNREA8 34,2576,1974
unscheduled DNA synthesis rat liver 130 µmol/L MUREAV 221,263,1989
mutation in microorganisms hamster ovary 2 mmol/L (+enzymatic activation step) MUREAV 90,183,1981
mutation in microorganisms Salmonella typhimurium 10 µmol/plate (+enzymatic activation step) CNREA8 34,2576,1974
mutation in microorganisms Salmonella typhimurium 10 µg/plate (-enzymatic activation step) TECSDY 15,101,1987
mutation in mammalian somatic cells hamster ovary 40 mmol/L MUREAV 90,183,1981
mutation in mammalian somatic cells human lymphocyte 100 mg/L MUREAV 142,133,1985
morphological transform hamster embryo 200 µL/plate EVSRBT 25,75,1982
morphological transform mouse fibroblast 0.1 pph/21 day (-enzymatic activation step) EMMUEG 35,300,2000
other mutation test systems Escherichia coli 316 mmol/L EMMUEG 19,98,1992
sex chromosome loss and nondisjunction Aspergillus nidulans 2,000 ppm MUREAV 201,401,1988
sex chromosome loss and nondisjunction oral
Drosophila melanogaster 		120 mmol/L MUREAV 285,209,1993
sex chromosome loss and nondisjunction inhalation
Drosophila melanogaster 		2 ppm/96 hour- continuous EVSRBT 32,65,1985
specific locus test oral
Drosophila melanogaster 		1,000 ppm MUREAV 57,163,1978
specific locus test inhalation
Drosophila melanogaster 		250 mg/m3 MUREAV 252,17,1991
specific locus test intraperitoneal
mouse 		300 mg/kg MUREAV 117,201,1983
specific locus test oral
mouse 		0.5 ppb EMMUEG 39,69,2002
specific locus test oral
rat 		0.5 ppb EMMUEG 39,69,2002


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 300 ppm/7 hour (6-15 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) BANRDU 5,149,1980
inhalation
rat 		lowest published toxic concentration: 208 mg/m3/6 hour (2 week prior to copulation/1-21 day pregnant) Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea) CHYCDW 23,199,1989
inhalation
rat 		lowest published toxic concentration: 57 mg/m3 (24 week prior to copulation) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on embryo or fetus: Fetal death 		VCVGH* -,364,1990


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mouse 		lowest published toxic concentration: 5 ppm/7 hour/78 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Skin and Appendages: Tumors 		BANRDU 5,3,1980
inhalation
rat 		lowest published toxic concentration: 5 ppm/7 hour/78 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Blood: Leukemia

Skin and Appendages: Tumors 		BANRDU 5,3,1980
oral
mouse 		lowest published toxic dose: 3,536 mg/kg/78 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Skin and Appendages: Tumors 		BANRDU 5,35,1980
oral
mouse 		toxic dose : 76 gm/kg/78 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Skin and Appendages: Tumors

Reproductive: Tumorigenic effects: Uterine tumors 		NCITR* NCI-TR-55,1978
oral
mouse 		toxic dose : 38 gm/kg/78 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Skin and Appendages: Tumors

Reproductive: Tumorigenic effects: Uterine tumors 		NCITR* NCI-TR-55,1978
oral
rat 		lowest published toxic dose: 5,286 mg/kg/69 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Tumors

Skin and Appendages: Tumors 		BANRDU 5,35,1980
oral
rat 		toxic dose : 38 gm/kg/78 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Vascular: Tumors

Gastrointestinal: Tumors 		NCITR* NCI-TR-55,1978
oral
rat 		toxic dose : 18 gm/kg/78 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Vascular: Tumors

Gastrointestinal: Tumors 		NCITR* NCI-TR-55,1978
skin
mouse 		lowest published toxic dose: 1,120 gm/kg/74 week- intermittent Tumorigenic: Neoplastic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Skin and Appendages: Tumors 		JJIND8 63,1433,1979


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
cat 		lethal concentration : >3,000 ppm/7 hour N/R JPETAB 84,53,1945
inhalation
dog 		lowest published lethal concentration: 20,000 mg/m3/4 hour N/R VCVGH* -,359,1990
inhalation
guinea pig 		lowest published lethal concentration: 1,500 ppm/7 hour Eye: Lacrimation

Behavioral: Somnolence (general depressed activity)

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) 		JPETAB 84,53,1945
inhalation
guinea pig 		lowest published lethal concentration: 8,000 mg/m3/8 hour N/R VCVGH* -,359,1990
inhalation
human 		lowest published toxic concentration: 6 mg/m3/15 minute Cardiac: Pulse rate decreased with fall in BP VCVGH* -,262,1990
inhalation
human 		lowest published toxic concentration: 100 mg/m3/6 hour Gastrointestinal: Nausea or vomiting VCVGH* -,262,1990
inhalation
human 		lowest published toxic concentration: 300 mg/m3/2 hour Behavioral: Somnolence (general depressed activity)

Behavioral: Headache

Gastrointestinal: Nausea or vomiting 		VCVGH* -,262,1990
inhalation
human 		lowest published toxic concentration: 250,000 mg/m3/30 minute Behavioral: Somnolence (general depressed activity)

Behavioral: Headache

Gastrointestinal: Nausea or vomiting 		VCVGH* -,262,1990
inhalation
mammal (species unspecified) 		lethal concentration : >3,000 ppm/7 hour N/R JPETAB 84,53,1945
inhalation
man 		lowest published toxic concentration: 4,000 ppm/1 hour Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Behavioral: Coma

Gastrointestinal: Nausea or vomiting 		PCOC** -,500,1966
inhalation
monkey 		lethal concentration (50 percent kill): 3,000 ppm/7 hour N/R 85JCAE -,93,1986
inhalation
monkey 		lowest published toxic concentration: 18,000 mg/m3/20 minute Eye: Lacrimation

Behavioral: Ataxia 		VCVGH* -,260,1990
inhalation
mouse 		lowest published lethal concentration: 5 gm/m3/2 hour N/R AEPPAE 141,19,1929
inhalation
mouse 		lowest published toxic concentration: 17,500 mg/m3/2 hour Behavioral: General anesthetic VCVGH* -,307,1990
inhalation
mouse 		lethal concentration (50 percent kill): 1,060 mg/m3/6 hour N/R VCVGH* -,359,1990
inhalation
pig 		lowest published lethal concentration: 3,000 ppm/7 hour Eye: Lacrimation

Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea 		JPETAB 84,53,1945
inhalation
rat 		lethal concentration (50 percent kill): 1,000 ppm/7 hour Behavioral: Coma

Lung, Thorax, or Respiration: Cyanosis

Nutritional and Gross Metabolic: Body temperature decrease 		AMIHBC 4,482,1951
inhalation
rat 		lowest published lethal concentration: 81,000 mg/m3/20 minute Behavioral: Coma VCVGH* -,359,1990
inhalation
rat 		lethal concentration (50 percent kill): 5,100 mg/m3/6 hour N/R VCVGH* -,359,1990
inhalation
rabbit 		lowest published lethal concentration: 3,000 ppm/7 hour Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea

Lung, Thorax, or Respiration: Other changes 		JPETAB 84,53,1945
inhalation
rabbit 		lowest published toxic concentration: 250 mg/m3/40 minute Behavioral: Alteration of classical conditioning VCVGH* -,260,1990
inhalation
rabbit 		lowest published toxic concentration: 8,000 mg/m3/8 hour Eye: Corneal damage VCVGH* -,366,1990
intraperitoneal
guinea pig 		lowest published lethal dose: 600 mg/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases AIHAAP 35,21,1974
intraperitoneal
mouse 		lethal dose (50 percent kill): 470 mg/kg N/R ARZNAD 11,902,1961
intraperitoneal
rat 		lethal dose (50 percent kill): 807 mg/kg N/R GTPZAB 26(4),26,1982
intratracheal
rat 		lowest published lethal dose: 120 mg/kg N/R NTIS** OTS0520615
intravenous
dog 		lowest published lethal dose: 175 mg/kg N/R QJPPAL 7,205,1934
oral
dog 		lethal dose (50 percent kill): 5,700 mg/kg Eye: Lacrimation

Behavioral: General anesthetic

Behavioral: Ataxia 		FAONAU 48A,91,1970
oral
dog 		lethal dose (50 percent kill): 2,500 mg/kg N/R VCVGH* -,360,1990
oral
guinea pig 		lethal dose (50 percent kill): 0.5 mL/kg N/R VCVGH* -,360,1990
oral
human 		lowest published lethal dose: 286 mg/kg Gastrointestinal: Ulceration or bleeding from stomach

Gastrointestinal: Nausea or vomiting

Liver: Fatty liver degeneration 		CLCEAL 86,203,1947
oral
human 		lowest published toxic dose: 428 mg/kg Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Cough

Gastrointestinal: Nausea or vomiting 		SOMEAU 22(10),132,1958
oral
man 		lowest published toxic dose: 892 mg/kg Gastrointestinal: Hypermotility, diarrhea

Gastrointestinal: Nausea or vomiting

Liver: Jaundice, other or unclassified 		WILEAR 28,983,1975
oral
man 		lowest published lethal dose: 714 mg/kg Behavioral: Somnolence (general depressed activity)

Cardiac: Change in rate

Lung, Thorax, or Respiration: Cyanosis 		KLWOAZ 48,822,1970
oral
mouse 		lethal dose (50 percent kill): 413 mg/kg Lung, Thorax, or Respiration: Other changes

Liver: Other changes 		EVHPAZ 43,41,1982
oral
mouse 		lethal dose (50 percent kill): 413 mg/kg N/R VCVGH* -,359,1990
oral
rat 		lethal dose (50 percent kill): 500 mg/kg N/R VCVGH* -,359,1990
oral
rat 		lowest published toxic dose: 628 mg/kg Liver: Hepatitis (hepatocellular necrosis), zonal

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects

Biochemical: Metabolism (intermediary): Other proteins 		TXCYAC 178,229,2002
oral
rabbit 		lethal dose (50 percent kill): 860 mg/kg N/R GUCHAZ 6,264,1973
oral
rabbit 		lethal dose (50 percent kill): 0.7 mL/kg N/R VCVGH* -,360,1990
subcutaneous
mouse 		lowest published lethal dose: 380 mg/kg N/R JPETAB 84,53,1945
subcutaneous
rat 		lethal dose (50 percent kill): 1 gm/kg Eye: Lacrimation

Behavioral: General anesthetic

Behavioral: Ataxia 		FAONAU 48A,91,1970
subcutaneous
rabbit 		lowest published lethal dose: 1,200 mg/kg N/R QJPPAL 7,205,1934
skin
rabbit 		lethal dose (50 percent kill): 2,800 mg/kg Eye: Lacrimation

Behavioral: General anesthetic

Behavioral: Ataxia 		FAONAU 48A,91,1970
unreported route
human 		lowest published lethal dose: 5 mg/kg N/R VCVGH* -,262,1990


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
cat 		lowest published toxic concentration: 1,000 ppm/7 hour/11 week- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field JIHTAB 28(4),113,1946
inhalation
dog 		lowest published toxic concentration: 1,500 ppm/7 hour/5 day- intermittent Eye: Corneal damage

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		AROPAW 32,391,1944
inhalation
guinea pig 		lowest published toxic concentration: 200 ppm/7 hour/25 week- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field JIHTAB 28(4),113,1946
inhalation
guinea pig 		lowest published toxic concentration: 1,500 ppm/7 hour/5 day- intermittent Cardiac: Other changes

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		JPETAB 84,53,1945
inhalation
monkey 		lowest published toxic concentration: 1,000 ppm/7 hour/9 week- intermittent Behavioral: Coma

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		JIHTAB 28(4),113,1946
inhalation
mouse 		lowest published toxic concentration: 200 ppm/7 hour/9 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field JIHTAB 28(4),113,1946
inhalation
rat 		lowest published toxic concentration: 200 ppm/7 hour/6 week- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field JIHTAB 28(4),113,1946
inhalation
rat 		lowest published toxic concentration: 1,500 ppm/7 hour/5 day- intermittent Lung, Thorax, or Respiration: Respiratory depression

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		JPETAB 84,53,1945
inhalation
rabbit 		lowest published toxic concentration: 400 ppm/7 hour/19 week- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field JIHTAB 28(4),113,1946
oral
mouse 		lowest published toxic dose: 43,680 mg/kg/13 week- continuous Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Kidney, Ureter, and Bladder: Changes in bladder weight 		NTPTR* NIH-91-3123
oral
mouse 		lowest published toxic dose: 685 mg/kg/14 day- intermittent Blood: Changes in leukocyte (WBC) count

Immunological Including Allergic: Decrease in humoral immune response 		EVHPAZ 43,41,1982
oral
rat 		lowest published toxic dose: 21,840 mg/kg/13 week- continuous Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight 		NTPTR* NIH-91-3123
oral
rat 		lowest published toxic dose: 1 gm/kg/10 day- intermittent Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Liver: Changes in liver weight

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		DCTODJ 17,463,1994


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 10 ppm DTLVS* TLV/BEI,2003
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not Classifiable as a Human Carcinogen DTLVS* TLV/BEI,2003
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 20,429,1979
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 71,501,1999
International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Data IMEMDT 20,429,1979
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 71,501,1999
International Agency for Research on Cancer (IARC) Cancer Review Group 2B IMEMDT 71,501,1999
TOXICOLOGY REVIEW
TOLED5 127,111,2002
TOXICOLOGY REVIEW
AIHAAP 40(3),A46,1979
TOXICOLOGY REVIEW
VHTODE 22,31,1980
TOXICOLOGY REVIEW
DCTODJ 5,319,1982
TOXICOLOGY REVIEW
NTIS** PB82-182825
TOXICOLOGY REVIEW
MUREAV 543,201,2003
TOXICOLOGY REVIEW
MUREAV 567,227,2004
TOXICOLOGY REVIEW
MUREAV 567,151,2004


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Cancelled RBREV* -,179,1998
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 50 ppm (200 mg/m3) DTLVS* 3,79,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 50 ppm;
ceiling concentration 100 ppm;
peak concentration 200 ppm/5 minute/3 hour 		CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 50 ppm (200 mg/m3) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 50 ppm (200 mg/m3) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 50 ppm (200 mg/m3) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - ARAB Republic of Egypt time-weighted average 5 ppm (2 mg/m3), JAN1993
Occupational Exposure Limit - AUSTRALIA time-weighted average 10 ppm (40 mg/m3), JAN1993
Occupational Exposure Limit - AUSTRIA Carcinogen, JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 10 ppm (40 mg/m3), JAN1993
Occupational Exposure Limit - FINLAND time-weighted average 10 ppm (40 mg/m3), short term exposure limit 20 ppm (80 mg/m3), Carcinogen, JAN1999
Occupational Exposure Limit - FRANCE VME 10 ppm (40 mg/m3), continuous2 Carcinogen, JAN1999
Occupational Exposure Limit - GERMANY Carcinogen, JAN1999
Occupational Exposure Limit - HUNGARY short term exposure limit 4 mg/m3, Carcinogen, JAN1993
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 7 mg/m3, 2003
Occupational Exposure Limit - NORWAY time-weighted average 1 ppm (4 mg/m3), JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 50 ppm (200 mg/m3), JAN1993
Occupational Exposure Limit - POLAND time-weighted average 50 mg/m3, short term exposure limit 60 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA time-weighted average 10 ppm, JAN1993
Occupational Exposure Limit - SWEDEN NGV 1 ppm (4 mg/m3), KTV 5 ppm (20 mg/m3), Skin, Carcinogen, JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 5 ppm (20 mg/m3), Carcinogen, JAN1999
Occupational Exposure Limit - TURKEY time-weighted average 50 ppm (200 mg/m3), JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 5 ppm (21 mg/m3), Skin, Carcinogen, SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Not Classifiable as a Human Carcinogen
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Not Classifiable as a Human Carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ETHYLENE DICHLORIDE-air Carcinogen;
10 hour time-weighted average 1 ppm;
short term exposure limit 2 ppm 		NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 24130;
Number of Industries 92;
Total Number of Facilities 7,148;
Number of Occupations 60;
Total Number of Employees Exposed 77,671
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 24130;
Number of Industries 38;
Total Number of Facilities 2,226;
Number of Occupations 61;
Total Number of Employees Exposed 83,246;
Total Number of Female Employees Exposed 33,361


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
ATSDR TOXICOLOGY PROFILE (NTIS** PB/2001/109103/AS)
EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat; Cell transform.-SA7/SHE
EPA GENETOX PROGRAM 1988, Positive: D melanogaster-whole sex chrom. loss
EPA GENETOX PROGRAM 1988, Positive: D melanogaster-nondisjunction; E coli polA without S9
EPA GENETOX PROGRAM 1988, Positive: Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Positive: D melanogaster Sex-linked lethal
EPA GENETOX PROGRAM 1988, Positive: CHO gene mutation
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in the production of VINYL CHLORIDE, and as a lead-scavenging agent in petrol
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH CURRENT INTELLIGENCE BULLETIN 25, 1978, AND BULLETIN 27, 1978
NIOSH Analytical Method, 1994: Hydrocarbons, halogenated, 1003
NCI Carcinogenesis Bioassay (gavage);clear evidence:mouse,rat NCITR* NCI-TR-55,1978
NTP 11th Report on Carcinogens,2004:Reasonably anticipated to be a human carcinogen
NTP Toxicity studies, RPT# TOX-04, October 2000
OSHA ANALYTICAL METHOD #03


REFERENCES:

CODEN
REFERENCE
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC.
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958-
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine. (Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
AROPAW Archives of Ophthalmology (Chicago). (AMA, 535 N. Dearborn St., Chicago, IL 60610) New series: V.1-44(3), 1929-50; V.64- 1960-
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
BANRDU Banbury Report. (Cold Spring Harbor Laboratory, POB 100, Cold Spring Harbor, NY 11724) V.1- 1979-
CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1975-
CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1969-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CHYCDW Zhonghua Yufangyixue Zazhi. Chinese Journal of Preventive Medicine. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) Beginning history not known.
CLCEAL Casopis Lekaru Ceskych. Journal of Czech Physicians. (ARTIA, Ve Smeckach 30, 111 27 Prague 1, Czeckoslovakia) V.1- 1862-
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Used in the production of VINYL CHLORIDE, and as a lead-scavenging agent in petrol

Top 50 chemical production: 15.94 billions lbs in 1992, 13.72 billions in 1991

NIOSH PROFILE (FUMIGANTS), SRC, 10/77

NIOSH PROFILE (GRAIN HANDLERS), SRI, 2/77

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Drug
   Mutagen
   Reproductive Effector
   Human Data
   Primary Irritant

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