The Registry of Toxic Effects of Chemical Substances
Ethane, pentachloro - |
UPDATE: November 2004 | MW: 202.28 | MF: C2HCl5 |
SYNONYMS: | |
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SKIN AND EYE IRRITATION DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
N/R | N/R | N/R | N/R |
MUTATION DATA AND REFERENCES: | |||
SYSTEM TEST |
ROUTE/ ORGANISM/ TISSUE | DOSE | REFERENCE |
cytogenetic analysis | hamster lung | 80 mg/L | MUREAV 369,243,1996 |
mutation in microorganisms | Saccharomyes cerevisiae | 2,500 痠ol/L (+enzymatic activation step) | TCMUD8 9,349,1989 |
mutation in mammalian somatic cells | mouse lymphocyte | 70 mg/L | EMMUEG 12,85,1988 |
other mutation test systems | Escherichia coli | 25,814 痠ol/L | EMMUEG 19,98,1992 |
other mutation test systems |
oral mouse | 500 mg/kg | MUREAV 343,157,1995 |
sister chromatid exchange | hamster ovary | 100 mg/L | SCIEAS 236,933,1987 |
sex chromosome loss and nondisjunction | human lung | 80 mg/L | MUREAV 369,243,1996 |
REPRODUCTIVE EFFECTS DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
N/R | N/R | N/R | N/R |
TUMORIGENIC DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
oral mouse | lowest published toxic dose: 71,750 mg/kg/103 week- intermittent |
Tumorigenic: Carcinogenic by RTECS criteria Liver: Tumors | NTIS** PB83-206748 |
oral rat | lowest published toxic dose: 108,150 mg/kg/103 week- intermittent |
Tumorigenic: Neoplastic by RTECS criteria Kidney, Ureter, and Bladder: Kidney tumors | NTIS** PB83-206748 |
ACUTE TOXICITY DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
inhalation cat | lowest published toxic concentration: 17 mg/m3 | Behavioral: General anesthetic | VCVGH* -,390,1990 |
inhalation mouse | lowest published toxic concentration: 7,500 mg/m3/2 hour | Behavioral: General anesthetic | VCVGH* -,307,1990 |
inhalation mouse | lowest published lethal concentration: 35,000 mg/m3/2 hour | N/R | VCVGH* -,390,1990 |
inhalation rat | lethal concentration (50 percent kill): 4,238 ppm/2 hour | N/R | 85JCAE -,97,1986 |
intravenous dog | lowest published lethal dose: 100 mg/kg | N/R | QJPPAL 7,205,1934 |
oral dog | lowest published lethal dose: 500 mg/kg |
Behavioral: Sleep Liver: Hepatitis (hepatocellular necrosis), zonal Liver: Fatty liver degeneration | AJHYA2 16,325,1932 |
oral rat | lethal dose (50 percent kill): 920 mg/kg |
Behavioral: Altered sleep time (including change in righting reflex) Behavioral: Ataxia Liver: Other changes | SRTCAC 36(1-4),10,1989 |
subcutaneous rabbit | lowest published lethal dose: 700 mg/kg | N/R | QJPPAL 7,205,1934 |
OTHER MULTIPLE DOSE DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
oral mouse | lowest published toxic dose: 32,500 mg/kg/13 week- intermittent | Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | NTPTR* NTP-TR-232,1982 |
oral mouse | lowest published toxic dose: 14 gm/kg/14 day- continuous | Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | NTPTR* NTP-TR-232,1982 |
oral rat | lowest published toxic dose: 7 gm/kg/14 day- continuous | Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | NTPTR* NTP-TR-232,1982 |
REVIEWS: | ||
ORGANIZATION | STANDARD |
REFERENCE |
International Agency for Research on Cancer (IARC) Cancer Review | Animal Limited Evidence | IMEMDT 41,99,1986 |
International Agency for Research on Cancer (IARC) Cancer Review | Animal Limited Evidence | IMEMDT 71,1519,1999 |
International Agency for Research on Cancer (IARC) Cancer Review | Human No Adequate Data | IMEMDT 41,99,1986 |
International Agency for Research on Cancer (IARC) Cancer Review | Human No Adequate Data | IMEMDT 71,1519,1999 |
International Agency for Research on Cancer (IARC) Cancer Review | Group 3 | IMEMDT 71,1519,1999 |
TOXICOLOGY REVIEW |
| AIHAAP 40(3),A46,1979 |
STANDARDS AND REGULATIONS: | ||
ORGANIZATION | STANDARD |
REFERENCE |
Occupational Exposure Limit - AUSTRIA | MAK 5 ppm (40 mg/m3), JAN1999 | |
Occupational Exposure Limit - FINLAND | time-weighted average 5 ppm (40 mg/m3), short term exposure limit 10 ppm (80 mg/m3), JAN1999 | |
Occupational Exposure Limit - GERMANY | MAK 5 ppm (40 mg/m3), JAN1999 | |
Occupational Exposure Limit - NORWAY | time-weighted average 5 ppm (40 mg/m3), JAN1999 | |
Occupational Exposure Limit - SWITZERLAND | MAK- week 5 ppm (40 mg/m3), KZG- week 10 ppm (80 mg/m3), JAN1999 | |
Occupational Exposure Limit - TURKEY | time-weighted average 5 ppm (40 mg/m3), JAN1993 | |
Occupational Exposure Limit - THE NETHERLANDS | MAC-TGG 40 mg/m3, 2003 |
NIOSH DOCUMENTATION AND SURVEILLANCE: | ||
ORGANIZATION | STANDARD or SURVEY |
REFERENCE |
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO PENTACHLOROETHANE-air | Handle with caution | NIOSH* DHHS #92-100,1992 |
National Occupational Exposure Survey 1983 |
National Occupational Exposure Survey 1983: Hazard Code: X6173![]() Number of Industries 1; Total Number of Facilities 3; Number of Occupations 7; Total Number of Employees Exposed 232; Total Number of Female Employees Exposed 3 |
STATUS IN FEDERAL AGENCIES: | |
ORGANIZATION |
REFERENCE |
EPA TSCA Section 8(b) CHEMICAL INVENTORY | |
Used in manufacture of TETRACHLOROETHYLENE and as solvent for CELLULOSE ACETATE | |
EPA TSCA Section 8(d) unpublished health/safety studies | |
On EPA IRIS database | |
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001 | |
NIOSH CURRENT INTELLIGENCE BULLETIN 27, 1978 | |
NIOSH Analytical Method, 1994: Pentachloroethane, 2517 | |
NCI Carcinogenesis Studies (gavage);clear evidence:mouse | |
NCI Carcinogenesis Studies (gavage);equivocal evidence:rat | |
NTP Toxicity studies, RPT# TOX-45, October 2000 |
REFERENCES: | |
CODEN |
REFERENCE |
85JCAE | "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 |
AIHAAP | American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958- |
AJHYA2 | American Journal of Hygiene. (Baltimore, MD) V.1-80, 1921-64. For publisher information, see AJEPAS. |
EMMUEG | Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- |
IMEMDT | IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- |
MUREAV | Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- |
NIOSH* | National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. |
NTIS** | National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. |
NTPTR* | National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206- |
QJPPAL | Quarterly Journal of Pharmacy & Pharmacology. (London, UK) V.2-21, 1929-48. For publisher information, see JPPMAB. |
SCIEAS | Science. (American Assoc. for the Advancement of Science, 1333 H St., NW, Washington, DC 20005) V.1- 1895- |
SRTCAC | Science Reports of the Research Institutes, Tohoku University, Series C: Medicine. (Tohoku University, Research Institute for Tuberculosis and Cancer, 4-1 Seiryo-machi, Sendai, Japan) V.1- 1949- |
TCMUD8 | Teratogenesis, Carcinogenesis, and Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1980- |
VCVGH* | "Vrednie chemichescie veshestva, galogenproisvodnie uglevodorodov". (Hazardous substances: Galogenated hydrocarbons) Bandman A.L. et al., Chimia, 1990. |