The Registry of Toxic Effects of Chemical Substances

Ethane, 1,1' - oxybis -

RTECS #: KI5775000

CAS #: 60-29-7

UPDATE: February 2005 MW: 74.14 MF: C4H10O


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. Aether
  2. Anaesthetic ether
  3. Anesthesia ether
  4. Anesthetic ether
  5. Diaethylaether (German)
  6. Diethyl ether (DOT:OSHA)
  7. Diethyl oxide
  8. Dwuetylowy eter (Polish)
  9. Etere etilico (Italian)
  1. Ether
  2. Ether ethylique (French)
  3. Ethoxyethane
  4. Ethyl ether
  5. Ethyl ether (ACGIH:OSHA)
  6. Oxyde d'ethyle (French)
  7. RCRA waste number U117
  8. Solvent ether


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
human 		100 ppm N/R JIHTAB 25,282,1943
eye
rabbit 		100 mg moderate FEPRA7 35,729,1976
skin
guinea pig 		50 mg/24 hour severe HIFUAG 22,373,1980
skin
rabbit 		360 mg open irritation test mild UCDS** 4/5/1973


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
DNA inhibition mouse embryo 2,850 mg/L JJATDK 5,1,1985
DNA repair Escherichia coli 35,670 µg/well/16 hour CBINA8 15,219,1976
other mutation test systems hamster fibroblast 1 pph ANESAV 43,21,1975


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
dog 		lowest published lethal concentration: 76,000 ppm N/R HBAMAK 4,1294,1935
inhalation
human 		lowest published toxic concentration: 200 ppm Olfaction: Other olfaction effects JIHTAB 25,282,1943
inhalation
human 		lowest published toxic concentration: 600 mg/m3/3 minute Lung, Thorax, or Respiration: Cough VCVGK* -,264,1994
inhalation
human 		lowest published toxic concentration: 100,000 mg/m3/30 minute Behavioral: General anesthetic VCVGK* -,264,1994
inhalation
mouse 		lethal concentration (50 percent kill): 31,000 ppm/30 minute Behavioral: Convulsions or effect on seizure threshold JIDOAA 34,379,1985
inhalation
mouse 		lowest published toxic concentration: 24,434 ppm/30 minute Behavioral: Alteration of classical conditioning TXAPA9 193,9,2003
inhalation
mouse 		lowest published toxic concentration: 30,000 ppm/30 minute Behavioral: Change in motor activity (specific assay)

Behavioral: Alteration of classical conditioning 		TXAPA9 193,9,2003
inhalation
rat 		lowest published lethal concentration: 32,000 ppm/4 hour N/R AIHAAP 23,95,1962
inhalation
rat 		lowest published toxic concentration: 7 pph Nutritional and Gross Metabolic: Body temperature decrease FATOAO 47,21,1984
inhalation
rabbit 		lowest published lethal concentration: 106,000 ppm N/R HBAMAK 4,1294,1935
inhalation
rabbit 		lowest published toxic concentration: 10,000 mg/m3/40 minute Peripheral Nerve and Sensation: Recording from peripheral motor nerve VCVGK* -,264,1994
intraperitoneal
guinea pig 		lowest published lethal dose: 2 gm/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases AIHAAP 35,21,1974
intraperitoneal
mouse 		lethal dose (50 percent kill): 2,420 mg/kg N/R PWPSA8 27,511,1984
intravenous
mouse 		lethal dose (50 percent kill): 996 mg/kg N/R JPMSAE 67,566,1978
oral
man 		lowest published lethal dose: 260 mg/kg N/R 85DCAI 2,73,1970
oral
mouse 		lethal dose (50 percent kill): 1,760 mg/kg N/R VCVGK* -,264,1994
oral
rat 		lethal dose (50 percent kill): 1,215 mg/kg N/R TXAPA9 19,699,1971
subcutaneous
frog 		lowest published lethal dose: 24 gm/kg N/R HBAMAK 4,1295,1935
subcutaneous
mouse 		lowest published lethal dose: 8 mg/kg N/R HBAMAK 4,1295,1935
skin
rabbit 		lethal dose (50 percent kill): >20 mL/kg N/R AIHAAP 23,95,1962


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
guinea pig 		lowest published toxic concentration: 1 pph/24 hour/5 week- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		ANESAV 42,408,1975
inhalation
mouse 		lowest published toxic concentration: 1,000 ppm/24 hour/5 week- continuous Liver: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		ANESAV 42,408,1975
oral
guinea pig 		lowest published toxic dose: 760 mg/kg/152 day- intermittent Behavioral: Alteration of classical conditioning VCVGK* -,265,1994
oral
guinea pig 		lowest published toxic dose: 7,600 mg/kg/152 day- intermittent Gastrointestinal: Gastritis VCVGK* -,265,1994
oral
rat 		lowest published toxic dose: 760 mg/kg/152 day- intermittent Behavioral: Alteration of classical conditioning VCVGK* -,265,1994
oral
rat 		lowest published toxic dose: 7,600 mg/kg/152 day- intermittent Gastrointestinal: Gastritis VCVGK* -,265,1994


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 400 ppm DTLVS* TLV/BEI,2002
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 400 ppm;short term exposure limit 500 ppm DTLVS* TLV/BEI,2003
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value short term exposure limit 500 ppm DTLVS* TLV/BEI,2002
International Agency for Research on Cancer (IARC) Cancer Review Animal No Adequate Data IMSUDL 7,93,1987
TOXICOLOGY REVIEW
TOLED5 140-141,249,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 400 ppm (1200 mg/m3) DTLVS* 3,106,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 400 ppm (1200 mg/m3) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 400 ppm (1200 mg/m3) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 400 ppm (1200 mg/m3) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 400 ppm (1200 mg/m3) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 400 ppm (1200 mg/m3), short term exposure limit 500 ppm, JAN1993
Occupational Exposure Limit - AUSTRIA MAK 400 ppm (1200 mg/m3), JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 400 ppm (1210 mg/m3), short term exposure limit 500 ppm, JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 400 ppm (1200 mg/m3), JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 400 ppm (1200 mg/m3), short term exposure limit 500 ppm (1500 mg/m3), JAN1999
Occupational Exposure Limit - FRANCE VME 400 ppm (1200 mg/m3), VLE 500 ppm (1500 mg/m3), JAN1999
Occupational Exposure Limit - GERMANY MAK 400 ppm (1200 mg/m3), JAN1999
Occupational Exposure Limit - HUNGARY time-weighted average 300 mg/m3, short term exposure limit 600 mg/m3, Skin, JAN1993
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 308 mg/m3, 2003
Occupational Exposure Limit - NORWAY time-weighted average 200 ppm (600 mg/m3), JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 400 ppm (1200 mg/m3), JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 300 mg/m3, MAC(short term exposure limit) 1500 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA time-weighted average 400 ppm, short term exposure limit 300 mg/m3, JAN1993
Occupational Exposure Limit - SWITZERLAND MAK- week 400 ppm (1200 mg/m3), KZG- week 800 ppm (2400 mg/m3), JAN1999
Occupational Exposure Limit - TURKEY time-weighted average 400 ppm (1200 mg/m3), JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 400 ppm (1230 mg/m3), short term exposure limit 500 ppm, SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

short term exposure limit 500 ppm
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
short term exposure limit 500 ppm


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 32590;
Number of Industries 112;
Total Number of Facilities 17,282;
Number of Occupations 82;
Total Number of Employees Exposed 161,572
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 32590;
Number of Industries 104;
Total Number of Facilities 21,212;
Number of Occupations 78;
Total Number of Employees Exposed 272,746;
Total Number of Female Employees Exposed 35,683


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Positive: E coli polA without S9
EPA GENETOX PROGRAM 1988, Negative: Aspergillus-forward mutation; Sperm morphology-mouse
EPA GENETOX PROGRAM 1988, Inconclusive: Histidine reversion-Ames test
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Ethyl ether, 1610


REFERENCES:

CODEN
REFERENCE
85DCAI "Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena, J.M., Springfield, IL, C.C. Thomas, 1970
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958-
ANESAV Anesthesiology. (Lippincott/Harper, Journal Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1- 1940-
CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1969-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939-
FEPRA7 Federation Proceedings, Federation of American Societies for Experimental Biology. (Bethesda, MD) V.1-46, 1942-87.
HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig, Ger. Dem. Rep.)
HIFUAG Hifu. Skin. (Nippon Hifuka Gakkai Osaka Chihokai, c/o Osaka Daigaku Igakubu, 1-1-50 Fukushima, Fukushima-ku, Osaka 553, Japan) V.1- 1959-
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979-
JIDOAA Experimental Animals. Jikken Dobutso Iho. (Nippon Jikken Dobutsu Gakkai, c/o Keio Gijuku Daigaku Igakubu Jikken Dobutsu Senta, 35 Shinano-machi, Shinjuku-ku, Tokyo 160, Japan) V.1- 1952-
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU.
JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd., Baffins Lane, Chichester, W. Sussex PO19 1UD, UK) V.1- 1981-
JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961-
PWPSA8 Proceedings of the Western Pharmacology Society. (Univ. of California Dept. of Pharmacology, Los Angeles, CA 90024) V.1- 1958-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817)
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.

RTECS Compound Description:
   Tumorigen
   Drug
   Mutagen
   Human Data
   Primary Irritant

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