The Registry of Toxic Effects of Chemical Substances

Ethane, 1,1 - dichloro -

RTECS #: KI0175000

CAS #: 75-34-3

UPDATE: November 2004 MW: 98.96 MF: C2H4Cl2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. NIOSH DOCUMENTATION AND SURVEILLANCE:
  10. STATUS IN FEDERAL AGENCIES:
  11. REFERENCES:

SYNONYMS:

  1. 1,1 - Dichloorethaan (Dutch)
  2. 1,1 - Dichloraethan (German)
  3. 1,1 - Dichlorethane
  4. 1,1 - Dichloroethane
  5. 1,1 - Dichloroethane (ACGIH:OSHA)
  6. 1,1 - Dicloroetano (Italian)
  7. Aethylidenchlorid (German)
  1. Chlorinated hydrochloric ether
  2. Chlorure d'ethylidene (French)
  3. Cloruro di etilidene (Italian)
  4. Ethylidene chloride (OSHA)
  5. Ethylidene dichloride
  6. NCI - C04535
  7. RCRA waste number U076


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
unscheduled DNA synthesis rat liver 13 mmol/L MUREAV 221,263,1989
sex chromosome loss and nondisjunction Aspergillus nidulans 2,000 ppm MUREAV 201,401,1988


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 6,000 ppm/7 hour (6-15 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system TXAPA9 28,452,1974


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 185 gm/kg/78 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Reproductive: Tumorigenic effects: Uterine tumors 		NCITR* NCI-TR-66,1978
oral
mouse 		toxic dose : 1,300 gm/kg/78 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Reproductive: Tumorigenic effects: Uterine tumors 		NCITR* NCI-TR-66,1978


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mouse 		lowest published toxic concentration: 30,000 mg/m3/2 hour Behavioral: General anesthetic VCVGH* -,355,1990
inhalation
mouse 		lowest published lethal concentration: 70,000 mg/m3/2 hour N/R VCVGH* -,355,1990
inhalation
rat 		lethal concentration (50 percent kill): 13,000 ppm/4 hour N/R NTIS** AD-A180-198
oral
rat 		lethal dose (50 percent kill): 725 mg/kg N/R HYSAAV 32(3),349,1967


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 240 gm/kg/12 week- intermittent Brain and Coverings: Recordings from specific areas of CNS

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		TOXID9 6,313,1986


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 100 ppm DTLVS* TLV/BEI,2003
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not Classifiable as a Human Carcinogen DTLVS* TLV/BEI,2003
TOXICOLOGY REVIEW
AIHAAP 40(3),A46,1979
TOXICOLOGY REVIEW
NTIS** PB82-182809
TOXICOLOGY REVIEW
MUREAV 543,201,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 200 ppm (320 mg/m3) DTLWS* 3,15,1973
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 100 ppm (400 mg/m3) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 100 ppm (400 mg/m3) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 100 ppm (400 mg/m3) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 100 ppm (400 mg/m3) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 200 ppm (810 mg/m3), short term exposure limit 250 ppm, JAN1993
Occupational Exposure Limit - AUSTRIA MAK 100 ppm (400 mg/m3), JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 200 ppm (810 mg/m3), short term exposure limit 250 ppm (1010 mg/m3), JAN1993
Occupational Exposure Limit - FINLAND time-weighted average 100 ppm (400 mg/m3), short term exposure limit 250 ppm (1000 mg/m3), JAN1999
Occupational Exposure Limit - FRANCE VME 200 ppm (810 mg/m3), JAN1999
Occupational Exposure Limit - GERMANY MAK 100 ppm (400 mg/m3), JAN1999
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 100 ppm (400 mg/m3), JAN1999
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 400 mg/m3, 2003
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 100 ppm (400 mg/m3), JAN1993
Occupational Exposure Limit - POLAND time-weighted average 50 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA time-weighted average 100 ppm, JAN1993
Occupational Exposure Limit - SWITZERLAND MAK- week 100 ppm (400 mg/m3), KZG- week 200 ppm (800 mg/m3), JAN1999
Occupational Exposure Limit - THAILAND time-weighted average 50 ppm, short term exposure limit 100 ppm, JAN1993
Occupational Exposure Limit - TURKEY time-weighted average 100 ppm (400 mg/m3), JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 200 ppm (823 mg/m3), short term exposure limit 400 ppm, SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Not Classifiable as a Human Carcinogen
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Not Classifiable as a Human Carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO 1,1-DICHLOROETHANE-air 10 hour time-weighted average 100 ppm NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 24120;
Number of Industries 7;
Total Number of Facilities 143;
Number of Occupations 9;
Total Number of Employees Exposed 715
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 24120;
Number of Industries 2;
Total Number of Facilities 10;
Number of Occupations 7;
Total Number of Employees Exposed 1,957;
Total Number of Female Employees Exposed 272


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
ATSDR TOXICOLOGY PROFILE (NTIS** PB/91/180539/AS)
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH CURRENT INTELLIGENCE BULLETIN 27, 1978
NIOSH Analytical Method, 1994: Hydrocarbons, halogenated, 1003
NCI Carcinogenesis Bioassay (gavage);equivocal evidence:mouse,rat NCITR* NCI-TR-66,1978


REFERENCES:

CODEN
REFERENCE
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
DTLWS* "Documentation of the Threshold Limit Values for Substances in Workroom Air," Supplements. For publisher information, see 85INA8.
HYSAAV Hygiene and Sanitation (USSR). English translation of GISAAA. (Springfield, VA) 1964-71. Discontinued.
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NCITR* National Cancer Institute Carcinogenesis Technical Report Series. (Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
VCVGH* "Vrednie chemichescie veshestva, galogenproisvodnie uglevodorodov". (Hazardous substances: Galogenated hydrocarbons) Bandman A.L. et al., Chimia, 1990.

RTECS Compound Description:
   Tumorigen
   Mutagen
   Reproductive Effector

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