RTECS:KI1425000 The Registry of Toxic Effects of Chemical Substances

The Registry of Toxic Effects of Chemical Substances

Ethane, 2,2 - difluoro - 1,1,1,2 - tetrachloro -

RTECS #: KI1425000

CAS #: 76-11-9

UPDATE: November 2004 MW: 203.82 MF: C₂Cl₄F₂

NOTE:

TOXICITY DATA HAVE NOT BEEN EVALUATED. OMISSION OF A SUBSTANCE OR NOTATION DOES NOT IMPLY ANY RELIEF FROM REGULATORY RESPONSIBILITY.

TABLE OF CONTENTS:

SYNONYMS:

ACUTE TOXICITY DATA:

OTHER MULTIPLE DOSE DATA:

REVIEWS:

STANDARDS AND REGULATIONS:

NIOSH DOCUMENTATION AND SURVEILLANCE:

STATUS IN FEDERAL AGENCIES:

REFERENCES:

SYNONYMS:

1,1,1,2 - Tetrachloro - 2,2 - difluoroethane

1,1,1,2 - Tetrachloro - 2,2 - difluoroethane (ACGIH:OSHA)

1,1 - Difluoro - 1,2,2,2 - tetrachloroethane

1,1 - Difluoroperchloroethane

CFC 112a

F 112a

Halocarbon 112a

R 112a

Refrigerant 112a

SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

MUTATION DATA AND REFERENCES:
SYSTEM TEST ROUTE/
ORGANISM/
TISSUE DOSE REFERENCE
N/R N/R N/R N/R

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

TUMORIGENIC DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
inhalation
mouse lowest published lethal concentration: 40,000 mg/m³/2 hour N/R VCVGH* -,634,1990
inhalation
mouse lethal concentration (50 percent kill): 123,000 mg/m³/2 hour N/R VCVGH* -,634,1990
inhalation
rat lowest published lethal concentration: 20,000 ppm/30 minute Behavioral: General anesthetic

Behavioral: Somnolence (general depressed activity)

Liver: Other changes TXAPA9 19,1,1971
inhalation
rat lowest published toxic concentration: 84,000 mg/m³ Behavioral: General anesthetic VCVGH* -,634,1990
inhalation
rat lethal concentration (50 percent kill): 125,000 mg/m³/4 hour N/R VCVGH* -,634,1990
inhalation
rat lowest published lethal concentration: 258,000 mg/m³/40 minute N/R VCVGH* -,634,1990
oral
rat lethal dose (50 percent kill): >8 gm/kg N/R NATUAS 210,744,1966

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
oral
rat lowest published toxic dose: 100 gm/kg/10 day- intermittent Behavioral: Somnolence (general depressed activity)

Behavioral: Tremor

Liver: Changes in liver weight VCVGH* -,635,1990

REVIEWS:
ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 500 ppm DTLVS* TLV/BEI,2003

STANDARDS AND REGULATIONS:
ORGANIZATION STANDARD
REFERENCE

Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 500 ppm (4170 mg/m³) DTLVS* 3,249,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 500 ppm (4170 mg/m³) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 500 ppm (4170 mg/m³) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 500 ppm (4170 mg/m³) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 500 ppm (4170 mg/m³) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 500 ppm (4170 mg/m³), JAN1993
Occupational Exposure Limit - AUSTRIA MAK 500 ppm (4179 mg/m³), JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 500 ppm (4170 mg/m³), JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 500 ppm (4170 mg/m³), JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 500 ppm (4170 mg/m³), short term exposure limit 625 ppm (5215 mg/m³), JAN1999
Occupational Exposure Limit - FRANCE VME 500 ppm (4170 mg/m³), JAN1999
Occupational Exposure Limit - GERMANY MAK 1000 ppm (8340 mg/m³), JAN1999
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 4170 mg/m³, 2003
Occupational Exposure Limit - SWITZERLAND MAK- week 500 ppm (4200 mg/m³), JAN1999
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 100 ppm (847 mg/m³), short term exposure limit 100 ppm, SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 500 ppm
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 500 ppm

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO 1,1,1,2-TETRACHLORO-2,2-DIFLUOROETHANE-air time-weighted average 500 ppm NIOSH* DHHS #92-100,1992

STATUS IN FEDERAL AGENCIES:
ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a refrigerant, corrosion inhibitor, and blowing agent
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: 1,1,1,2-Tetrachloro-2,2-difluoroethane, 1016
NIOSH Analytical Method, 1996: 1,1,2,2-Tetrachloro-1,2-difluoroethane, 1016

REFERENCES:
CODEN
REFERENCE

CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736) V.1- 1869-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
VCVGH* "Vrednie chemichescie veshestva, galogenproisvodnie uglevodorodov". (Hazardous substances: Galogenated hydrocarbons) Bandman A.L. et al., Chimia, 1990.

Used as a refrigerant, corrosion inhibitor, and blowing agent

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SYNONYMS:
1,1,1,2 - Tetrachloro - 2,2 - difluoroethane 1,1,1,2 - Tetrachloro - 2,2 - difluoroethane (ACGIH:OSHA) 1,1 - Difluoro - 1,2,2,2 - tetrachloroethane 1,1 - Difluoroperchloroethane CFC 112a	F 112a Halocarbon 112a R 112a Refrigerant 112a

SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

MUTATION DATA AND REFERENCES:
SYSTEM TEST	ROUTE/ ORGANISM/ TISSUE	DOSE	REFERENCE
N/R	N/R	N/R	N/R

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

TUMORIGENIC DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
inhalation mouse	lowest published lethal concentration: 40,000 mg/m³/2 hour	N/R	VCVGH* -,634,1990
inhalation mouse	lethal concentration (50 percent kill): 123,000 mg/m³/2 hour	N/R	VCVGH* -,634,1990
inhalation rat	lowest published lethal concentration: 20,000 ppm/30 minute	Behavioral: General anesthetic Behavioral: Somnolence (general depressed activity) Liver: Other changes	TXAPA9 19,1,1971
inhalation rat	lowest published toxic concentration: 84,000 mg/m³	Behavioral: General anesthetic	VCVGH* -,634,1990
inhalation rat	lethal concentration (50 percent kill): 125,000 mg/m³/4 hour	N/R	VCVGH* -,634,1990
inhalation rat	lowest published lethal concentration: 258,000 mg/m³/40 minute	N/R	VCVGH* -,634,1990
oral rat	lethal dose (50 percent kill): >8 gm/kg	N/R	NATUAS 210,744,1966

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
oral rat	lowest published toxic dose: 100 gm/kg/10 day- intermittent	Behavioral: Somnolence (general depressed activity) Behavioral: Tremor Liver: Changes in liver weight	VCVGH* -,635,1990

REVIEWS:
ORGANIZATION	STANDARD	REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value	time-weighted average 500 ppm	DTLVS* TLV/BEI,2003

STANDARDS AND REGULATIONS:
ORGANIZATION	STANDARD	REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD - air	time-weighted average 500 ppm (4170 mg/m³)	DTLVS* 3,249,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)	8 hour time-weighted average 500 ppm (4170 mg/m³)	CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)	8 hour time-weighted average 500 ppm (4170 mg/m³)	CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)	8 hour time-weighted average 500 ppm (4170 mg/m³)	CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)	8 hour time-weighted average 500 ppm (4170 mg/m³)	CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA	time-weighted average 500 ppm (4170 mg/m³), JAN1993
Occupational Exposure Limit - AUSTRIA	MAK 500 ppm (4179 mg/m³), JAN1999
Occupational Exposure Limit - BELGIUM	time-weighted average 500 ppm (4170 mg/m³), JAN1993
Occupational Exposure Limit - DENMARK	time-weighted average 500 ppm (4170 mg/m³), JAN1999
Occupational Exposure Limit - FINLAND	time-weighted average 500 ppm (4170 mg/m³), short term exposure limit 625 ppm (5215 mg/m³), JAN1999
Occupational Exposure Limit - FRANCE	VME 500 ppm (4170 mg/m³), JAN1999
Occupational Exposure Limit - GERMANY	MAK 1000 ppm (8340 mg/m³), JAN1999
Occupational Exposure Limit - THE NETHERLANDS	MAC-TGG 4170 mg/m³, 2003
Occupational Exposure Limit - SWITZERLAND	MAK- week 500 ppm (4200 mg/m³), JAN1999
Occupational Exposure Limit - UNITED KINGDOM	time-weighted average 100 ppm (847 mg/m³), short term exposure limit 100 ppm, SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA	American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value; time-weighted average 500 ppm
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM	American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 500 ppm

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION	STANDARD or SURVEY	REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO 1,1,1,2-TETRACHLORO-2,2-DIFLUOROETHANE-air	time-weighted average 500 ppm	NIOSH* DHHS #92-100,1992

STATUS IN FEDERAL AGENCIES:
ORGANIZATION	REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a refrigerant, corrosion inhibitor, and blowing agent
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: 1,1,1,2-Tetrachloro-2,2-difluoroethane, 1016
NIOSH Analytical Method, 1996: 1,1,2,2-Tetrachloro-1,2-difluoroethane, 1016

REFERENCES:
CODEN	REFERENCE
CFRGBR	Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS*	The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
NATUAS	Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736) V.1- 1869-
NIOSH*	National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
TXAPA9	Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
VCVGH*	"Vrednie chemichescie veshestva, galogenproisvodnie uglevodorodov". (Hazardous substances: Galogenated hydrocarbons) Bandman A.L. et al., Chimia, 1990.