The Registry of Toxic Effects of Chemical Substances
Ethane, 1,2 - diethoxy - RTECS #: KI1225000
CAS #: 629-14-1
The Registry of Toxic Effects of Chemical Substances
Ethane, 1,2 - diethoxy - |
| UPDATE: May 2003 | MW: 118.20 | MF: C6H14O2 |
SYNONYMS:
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SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
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eye | rabbit
100 mg
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severe
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AJOPAA 29,1363,1946
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MUTATION DATA AND REFERENCES:
SYSTEM TEST
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ROUTE/ | ORGANISM/ TISSUE
DOSE
|
REFERENCE
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N/R
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N/R
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N/R
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N/R
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REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
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oral | mouse
lowest published toxic dose: 23,640 mg/kg (7-14 day pregnant)
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Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)
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EVHPAZ 57,141,1984
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oral | mouse
lowest published toxic dose: 23,640 mg/kg (6-13 day pregnant)
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Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) | Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
TCMUD8 7,29,1987
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oral | mouse
lowest published toxic dose: 5,000 mg/kg (6-15 day pregnant)
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Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue) | Reproductive: Specific developmental abnormalities: Musculoskeletal system
NTIS** PB88-134093
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oral | mouse
lowest published toxic dose: 1.5 gm/kg (6-15 day pregnant)
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Reproductive: Other developmental abnormalities
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NTIS** #PB88-134093
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oral | mouse
lowest published toxic dose: 5 gm/kg (6-15 day pregnant)
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Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)
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NTIS** #PB88-134093
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oral | mouse
lowest published toxic dose: 10 gm/kg (6-15 day pregnant)
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Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) | Reproductive: Effects on embryo or fetus: Fetal death
NTIS** #PB88-134093
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oral | rabbit
lowest published toxic dose: 1,400 mg/kg (6-19 day pregnant)
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Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) | Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) Reproductive: Specific developmental abnormalities: Musculoskeletal system
FAATDF 19,15,1992
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oral | rabbit
lowest published toxic dose: 1.4 gm/kg (6-19 day pregnant)
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Reproductive: Effects on embryo or fetus: Fetal death | Reproductive: Specific developmental abnormalities: Musculoskeletal system Reproductive: Other developmental abnormalities
NTIS** #PB88-157516/AS
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TUMORIGENIC DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
|
N/R |
N/R
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N/R
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N/R
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ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
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inhalation | dog
lowest published toxic concentration: 50,000 mg/m3/1 hour
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Behavioral: General anesthetic | Lung, Thorax, or Respiration: Cough
VCVGK* -,319,1984
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inhalation | guinea pig
lowest published toxic concentration: 50,000 mg/m3/1 hour
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Behavioral: General anesthetic | Lung, Thorax, or Respiration: Cough
VCVGK* -,319,1984
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inhalation | rat
lowest published lethal concentration: 8,000 ppm/4 hour
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N/R
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JIHTAB 31,343,1949
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inhalation | rabbit
lowest published toxic concentration: 50,000 mg/m3/1 hour
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Behavioral: General anesthetic | Lung, Thorax, or Respiration: Cough
VCVGK* -,319,1984
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oral | guinea pig
lethal dose (50 percent kill): 2,440 mg/kg
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Behavioral: General anesthetic | Gastrointestinal: Other changes Kidney, Ureter, and Bladder: Other changes
JIHTAB 23,259,1941
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oral | rat
lethal dose (50 percent kill): 4,390 mg/kg
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Behavioral: General anesthetic | Gastrointestinal: Other changes Kidney, Ureter, and Bladder: Other changes
JIHTAB 23,259,1941
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oral | rat
lethal dose (16 percent kill): 840 mg/kg
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N/R
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VCVGK* -,319,1984
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oral | rat
lethal dose (50 percent kill): 2,350 mg/kg
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N/R
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VCVGK* -,319,1984
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oral | rat
lethal dose (84 percent kill): 3,570 mg/kg
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N/R
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VCVGK* -,319,1984
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oral | rabbit
lethal dose (16 percent kill): 760 mg/kg
|
N/R
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VCVGK* -,319,1984
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oral | rabbit
lethal dose (50 percent kill): 1,275 mg/kg
|
N/R
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VCVGK* -,319,1984
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oral | rabbit
lethal dose (84 percent kill): 1,580 mg/kg
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N/R
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VCVGK* -,319,1984
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OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
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inhalation | cat
lowest published toxic concentration: 2,500 mg/m3/8 hour/12 day- intermittent
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Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi | Kidney, Ureter, and Bladder: Other changes Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
VCVGK* -,320,1994
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inhalation | rabbit
lowest published toxic concentration: 2,500 mg/m3/8 hour/12 day- intermittent
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Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi | Kidney, Ureter, and Bladder: Other changes Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
VCVGK* -,320,1994
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oral | mouse
lowest published toxic dose: 10,000 mg/kg/10 day- intermittent
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Nutritional and Gross Metabolic: Weight loss or decreased weight gain
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NTIS** #PB88-134093
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oral | rabbit
lowest published toxic dose: 1,400 mg/kg/14 day- intermittent
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Nutritional and Gross Metabolic: Weight loss or decreased weight gain
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NTIS** #PB89-165849
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REVIEWS:
ORGANIZATION
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STANDARD
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REFERENCE
N/R
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N/R
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N/R
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STANDARDS AND REGULATIONS:
ORGANIZATION
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STANDARD
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REFERENCE
N/R
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N/R
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N/R
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NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION
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STANDARD or SURVEY
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REFERENCE
N/R
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N/R
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N/R
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STATUS IN FEDERAL AGENCIES:
ORGANIZATION
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REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
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Used as aprotic solvent
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EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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REFERENCES:
CODEN
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REFERENCE
AJOPAA
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American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N. Michigan Ave., Suite 1415,
Chicago, IL 60611) Series 3: V.1- 1918-
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EVHPAZ
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EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents,
Washington, DC 20402) No.1- 1972-
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FAATDF
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Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802)
V.1-40, 1981-97. For publisher information, see TOSCF2
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JIHTAB
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Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For
publisher information, see AEHLAU.
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NTIS**
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National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse
for Scientific & Technical Information.
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TCMUD8
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Teratogenesis, Carcinogenesis, and Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New
York, NY 10003) V.1- 1980-
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VCVGK*
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"Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia".
(Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia,
1994.
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