The Registry of Toxic Effects of Chemical Substances

Ethane, 2,2 - dichloro - 1,1,1 - trifluoro -

RTECS #: KI1108000

CAS #: 306-83-2

UPDATE: May 2005 MW: 152.93 MF: C2HCl2F3


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. TUMORIGENIC DATA:
  6. ACUTE TOXICITY DATA:
  7. OTHER MULTIPLE DOSE DATA:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. CFC - 123
  2. Chlorofluorocarbon 123
  3. 2,2 - Dichloro - 1,1,1 - trifluoroethane
  4. Dichloro (trifluoromethyl) methane
  5. Freon 123
  6. HCFC 123
  7. HFA 123
  1. Hydrochlorofluorocarbon
  2. R 123
  3. Solkane 123
  4. FC 123
  5. Refrigerant HCFC - 123
  6. Refrigerant R 123
  7. 1,1,1 - Trifluoro - 2,2 - dichloroethane


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		100 µL mild NTIS** OTS0530607


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis human lymphocyte 50 ppm/24 hour (-enzymatic activation step) NTIS** OTS0530498-1
cytogenetic analysis human lymphocyte 30 pph/3 hour (+enzymatic activation step) NTIS** OTS0530498-1


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 300 ppm/6 hour (4 week male/4 week prior to copulation-7 week after birth) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) FAATDF 34,276,1996
inhalation
rat 		lowest published toxic concentration: 1,000 ppm/6 hour (22 week male) Reproductive: Other effects on male NTIS** OTS0557691
inhalation
rabbit 		lowest published toxic dose: 500 ppm/6 hour (6-18 day pregnant) Reproductive: Other effects on female TJADAB 51,196,1996


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 5,000 ppm/6 hour/2 year- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors 		NTIS** OTS0530498-3
inhalation
rat 		lowest published toxic concentration: 5,000 ppm/6 hour/2 year- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors 		NTIS** OTS0543416


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
guinea pig 		lowest published toxic concentration: 5,000 ppm/4 hour Liver: Hepatitis (hepatocellular necrosis), zonal

Liver: Fatty liver degeneration

Liver: Liver function tests impaired 		ARTODN 75,274,2001
inhalation
mouse 		lethal concentration (50 percent kill): 74,000 ppm/1 hour N/R BJANAD 37,716,1965
inhalation
mouse 		lowest published toxic concentration: 451,500 mg/m3/1 hour Behavioral: Convulsions or effect on seizure threshold

Behavioral: Excitement 		VCVGH* -,635,1990
inhalation
rat 		lethal concentration (50 percent kill): 32,000 ppm/4 hour Behavioral: Somnolence (general depressed activity)

Behavioral: Change in motor activity (specific assay)

Lung, Thorax, or Respiration: Dyspnea 		NTIS** OTS0530611
inhalation
rat 		lethal concentration (50 percent kill): 225,700 mg/m3/4 hour N/R VCVGH* -,635,1990
intraperitoneal
guinea pig 		lowest published toxic dose: 153 mg/kg Liver: Liver function tests impaired

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)

Biochemical: Metabolism (intermediary): Other proteins 		TOLED5 144,35,2003
intraperitoneal
guinea pig 		lowest published toxic dose: 1,529 mg/kg Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Metabolism (intermediary): Other proteins 		TOLED5 144,35,2003
oral
rat 		lowest published lethal dose: 9 gm/kg Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Respiratory stimulation 		NTIS** OTS0530608
skin
rat 		lethal dose (50 percent kill): >2 gm/kg N/R NTIS** OTS0530598
skin
rabbit 		lethal dose (50 percent kill): >2 gm/kg N/R NTIS** OTS0530597


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
dog 		lowest published toxic concentration: 10,000 ppm/6 hour/13 week- intermittent Behavioral: Somnolence (general depressed activity)

Liver: Hepatitis (hepatocellular necrosis), diffuse

Blood: Changes in erythrocyte (RBC) count 		NTIS** OTS0530613
inhalation
guinea pig 		lowest published toxic concentration: 5,000 ppm/4 hour/5 day- intermittent Liver: Hepatitis (hepatocellular necrosis), zonal

Liver: Fatty liver degeneration

Liver: Liver function tests impaired 		ARTODN 75,274,2001
inhalation
rat 		lowest published toxic concentration: 300 ppm/6 hour/13 week- intermittent Liver: Other changes

Endocrine: Hypoglycemia

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) 		NTIS** OTS0530615
inhalation
rat 		lowest published toxic concentration: 1,000 ppm/6 hour/90 day- intermittent Liver: Changes in liver weight

Endocrine: Changes in adrenal weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		NTIS** OTS0528777
inhalation
rat 		lowest published toxic concentration: 10,000 ppm/6 hour/4 week- intermittent Behavioral: General anesthetic

Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		NTIS** OTS0530616
inhalation
rat 		lowest published toxic concentration: 300 ppm/6 hour/2 year- intermittent Liver: Other changes

Kidney, Ureter, and Bladder: Other changes in urine composition

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) 		NTIS** OTS0543416
inhalation
rabbit 		lowest published toxic concentration: 500 ppm/13 day- intermittent Behavioral: Food intake (animal)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		TJADAB 51,196,1995


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
N/R N/R N/R


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974-
BJANAD British Journal of Anesthesia. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.1- 1923-
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
VCVGH* "Vrednie chemichescie veshestva, galogenproisvodnie uglevodorodov". (Hazardous substances: Galogenated hydrocarbons) Bandman A.L. et al., Chimia, 1990.

RTECS Compound Description:
   Tumorigen
   Drug
   Mutagen
   Reproductive Effector
   Primary Irritant

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