The Registry of Toxic Effects of Chemical Substances

Ethane, 1,2 - dibutoxy -

RTECS #: KH9450000

CAS #: 112-48-1

UPDATE: February 2003 MW: 174.32 MF: C10H22O2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. ACUTE TOXICITY DATA:
  4. REFERENCES:

SYNONYMS:

  1. 1,2 - Dibutoxyethane
  2. Dibutyl cellosolve
  3. Dibutylether ethylenglykolu (Czech)
  4. Dibutyl Oxitol
  1. Butane, 1,1' - (1,2 - ethanediylbis (oxy) ) bis - (9CI)
  2. Glycol dibutyl ether
  3. Ethylene glycol dibutyl ether


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
skin
rabbit 		500 mg open irritation test mild UCDS** 11/7/1957


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lethal dose (16 percent kill): 870 mg/kg N/R VCVGK* -,320,1984
oral
rat 		lethal dose (50 percent kill): 2,650 mg/kg N/R VCVGK* -,320,1984
oral
rat 		lethal dose (84 percent kill): 6,100 mg/kg N/R VCVGK* -,320,1984
oral
rabbit 		lethal dose (16 percent kill): 1,080 mg/kg N/R VCVGK* -,319,1984
oral
rabbit 		lethal dose (50 percent kill): 1,425 mg/kg N/R VCVGK* -,319,1984
oral
rabbit 		lethal dose (84 percent kill): 1,890 mg/kg N/R VCVGK* -,319,1984
skin
rabbit 		lethal dose (50 percent kill): 3,560 µL/kg N/R AMIHBC 10,61,1954
unreported route
rat 		lowest published toxic dose: 265 mg/kg Endocrine: Hyperglycemia

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Blood: Changes in erythrocyte (RBC) count 		VCVGK* -,320,1984
unreported route
rabbit 		lowest published toxic dose: 142.5 mg/kg Endocrine: Hyperglycemia

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Blood: Changes in erythrocyte (RBC) count 		VCVGK* -,320,1984


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
N/R N/R N/R


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
N/R


REFERENCES:

CODEN
REFERENCE
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine. (Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817)
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.

RTECS Compound Description:
   Primary Irritant

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