The Registry of Toxic Effects of Chemical Substances

Ethane, bromo -

RTECS #: KH6475000

CAS #: 74-96-4

UPDATE: February 2005 MW: 108.98 MF: C2H5Br


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. TUMORIGENIC DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. Bromic ether
  2. Bromoethane
  3. Bromure d'ethyle
  4. Ethyl bromide
  5. Ethyl bromide (ACGIH:OSHA)
  1. Etylu bromek (Polish)
  2. Halon 2001
  3. Hydrobromic ether
  4. Monobromoethane
  5. NCI - C55481


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
mutation in microorganisms Salmonella typhimurium 75 ng/plate (+enzymatic activation step) NTPTR* NTP-TR-363,1989
sister chromatid exchange hamster ovary 100 mg/L EMMUEG 13,60,1989


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mouse 		lowest published toxic concentration: 200 ppm/6 hour/2 year- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Reproductive: Tumorigenic effects: Uterine tumors 		NTPTR* NTP-TR-363,1989
inhalation
rat 		lowest published toxic concentration: 100 ppm/6 hour/2 year- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Brain and Coverings: Tumors 		NTPTR* NTP-TR-363,1989


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
cat 		lethal concentration (50 percent kill): 550,000 mg/m3/40 minute N/R VCVGH* -,584,1990
inhalation
dog 		lowest published lethal concentration: 80,000 mg/m3/1 hour Brain and Coverings: Other degenerative changes

Behavioral: Ataxia 		VCVGH* -,584,1990
inhalation
guinea pig 		lowest published lethal concentration: 44,000 mg/m3 Behavioral: General anesthetic VCVGH* -,584,1990
inhalation
mouse 		lethal concentration (50 percent kill): 16,230 ppm/1 hour Behavioral: Somnolence (general depressed activity)

Gastrointestinal: Hypermotility, diarrhea 		AMRL** TR-72-62,1972
inhalation
mouse 		lowest published toxic concentration: 85,000 mg/m3/15 minute Behavioral: General anesthetic VCVGH* -,584,1990
inhalation
mouse 		lowest published lethal concentration: 15,000 mg/m3/6 hour Cardiac: Other changes

Liver: Fatty liver degeneration

Kidney, Ureter, and Bladder: Other changes 		VCVGH* -,584,1990
inhalation
mouse 		lethal concentration (50 percent kill): 36,000 mg/m3/2 hour N/R VCVGH* -,572,1990
inhalation
rat 		lethal concentration (50 percent kill): 26,980 ppm/1 hour N/R AMRL** TR-72-62,1972
inhalation
rat 		lethal concentration (50 percent kill): 534,000 mg/m3/4 hour N/R VCVGH* -,572,1990
inhalation
rabbit 		lowest published lethal concentration: 40,000 mg/m3 N/R VCVGH* -,584,1990
intraperitoneal
mouse 		lethal dose (50 percent kill): 573 mg/kg N/R VCVGH* -,572,1990
intraperitoneal
rat 		lethal dose (50 percent kill): 1,750 mg/kg N/R JPCEAO 320,133,1978
oral
rat 		lethal dose (50 percent kill): 1,350 mg/kg N/R 85GMAT -,65,1982


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mouse 		lowest published toxic concentration: 1 pph/6 hour/14 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field NTPTR* NTP-TR-363,1989
inhalation
rat 		lowest published toxic concentration: 2 pph/6 hour/14 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field NTPTR* NTP-TR-363,1989
inhalation
rat 		lowest published toxic concentration: 1,600 ppm/6 hour/14 week- intermittent Blood: Changes in spleen

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		NTPTR* NTP-TR-363,1989
inhalation
rat 		lowest published toxic concentration: 47 mg/m3/4 hour/20 week- intermittent Liver: Other changes VCVGH* -,585,1990
inhalation
rabbit 		lowest published toxic concentration: 47 mg/m3/4 hour/20 week- intermittent Liver: Other changes VCVGH* -,585,1990


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 5 ppm (skin) DTLVS* TLV/BEI,2003
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Confirmed Animal Carcinogen with Unknown DTLVS* TLV/BEI,2003
International Agency for Research on Cancer (IARC) Cancer Review Animal Limited Evidence IMEMDT 52,299,1991
International Agency for Research on Cancer (IARC) Cancer Review Animal Limited Evidence IMEMDT 71,1305,1999
International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Data IMEMDT 71,1305,1999
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMEMDT 71,1305,1999
TOXICOLOGY REVIEW
MUREAV 543,201,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 200 ppm (890 mg/m3) DTLVS* 3,105,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 200 ppm (890 mg/m3) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 200 ppm (890 mg/m3) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 200 ppm (890 mg/m3) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 200 ppm (890 mg/m3) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 200 ppm (890 mg/m3), short term exposure limit 250 ppm, JAN1993
Occupational Exposure Limit - AUSTRIA Carcinogen, JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 200 ppm (891 mg/m3), short term exposure limit 250 ppm (1100 mg/m3), JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 5 ppm (22 mg/m3), Skin, JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 200 ppm (890 mg/m3), short term exposure limit 250 ppm (1115 mg/m3), JAN1999
Occupational Exposure Limit - FRANCE VME 288 ppm (890 mg/m3), JAN1999
Occupational Exposure Limit - GERMANY Carcinogen, JAN1999
Occupational Exposure Limit - HUNGARY time-weighted average 50 mg/m3, short term exposure limit 100 mg/m3, Skin, JAN1993
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 22 mg/m3, Skin, 2003
Occupational Exposure Limit - NORWAY time-weighted average 5 ppm (22 mg/m3), JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 300 ppm (890 mg/m3), JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 50 mg/m3, MAC(short term exposure limit) 400 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA short term exposure limit 5 mg/m3, JAN1993
Occupational Exposure Limit - SWITZERLAND MAK- week 5 ppm (22 mg/m3), Skin, Carcinogen, JAN1999
Occupational Exposure Limit - TURKEY time-weighted average 200 ppm (890 mg/m3), JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 200 ppm (906 mg/m3), short term exposure limit 250 ppm, SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Confirmed Animal Carcinogen with Unknown
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Confirmed Animal Carcinogen with Unknown


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 31900;
Number of Industries 1;
Total Number of Facilities 14;
Number of Occupations 1;
Total Number of Employees Exposed 196
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 31900;
Number of Industries 15;
Total Number of Facilities 1,452;
Number of Occupations 13;
Total Number of Employees Exposed 12,285;
Total Number of Female Employees Exposed 1,535


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster Sex-linked lethal
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as an industrial chemical, pharmaceutical and veterinary drug
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Ethyl bromide, 1011
NCI Carcinogenesis Studies (inhal);clear evidence:mouse
NTP Carcinogenesis Studies (inhalation);some evidence:rat NTPTR* NTP-TR-363,1989
NCI Carcinogenesis Studies (inhal);equivocal evidence:rat


REFERENCES:

CODEN
REFERENCE
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982
AMRL** Aerospace Medical Research Laboratory Report. (Aerospace Technical Div., Air Force Systems Command, Wright-Patterson Air Force Base, OH 45433)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
JPCEAO Journal fuer Praktische Chemie. (Johann Ambrosius Barth Verlag, Postfach 109, Leipzig DDR-7010, Ger. Dem. Rep.) V.1- 1834-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206-
VCVGH* "Vrednie chemichescie veshestva, galogenproisvodnie uglevodorodov". (Hazardous substances: Galogenated hydrocarbons) Bandman A.L. et al., Chimia, 1990.

Used as an industrial chemical, pharmaceutical and veterinary drug

NIOSH PROFILE (ALIPHATICS, BROMINATED), SRI, 2/77

RTECS Compound Description:
   Tumorigen
   Mutagen

 Click Here for Additional Information about RTECS