The Registry of Toxic Effects of Chemical Substances

Ethanaminium, 2 - hydroxy - N,N,N - trimethyl - , chloride

RTECS #: KH2975000

CAS #: 67-48-1

UPDATE: August 2004 MW: 139.65 MF: C5H14NO•Cl


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. STANDARDS AND REGULATIONS:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. Ammonium, (2 - hydroxyethyl) trimethyl - , chloride
  2. Chloride de choline (French)
  3. Choline chlorhydrate
  4. Choline chloride
  5. Choline hydrochloride
  1. Cholinium chloride
  2. Biocolina
  3. Hepacholine
  4. (2 - Hydroxyethyl) trimethylammonium chloride
  5. Lipotril


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis hamster ovary 500 µg/L ENMUDM 7,1,1985
sister chromatid exchange hamster ovary 500 µg/L ENMUDM 7,1,1985


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intracerebral
rat 		lowest published toxic dose: 300 µg/kg Endocrine: Hyperglycemia EJPHAZ 438,197,2002
intracerebral
rat 		lowest published toxic dose: 200 µg/kg Vascular: BP elevation not characterized in autonomic section BJMRDK 34,815,2001
intraperitoneal
mouse 		lethal dose (50 percent kill): 320 mg/kg N/R PSEBAA 51,281,1942
intraperitoneal
rat 		lethal dose (50 percent kill): 450 mg/kg N/R IJEBA6 24,91,1986
intraperitoneal
rat 		lowest published toxic dose: 120 mg/kg Endocrine: Hyperglycemia EJPHAZ 438,197,2002
intraperitoneal
rabbit 		lowest published lethal dose: 500 mg/kg Eye: Corneal damage

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Other changes 		JIDIAQ 42,473,1928
intravenous
cat 		lowest published lethal dose: 25 mg/kg N/R HBAMAK 4,1289,1935
intravenous
dog 		lowest published lethal dose: 5 mg/kg N/R HBAMAK 4,1289,1935
intravenous
mouse 		lethal dose (50 percent kill): 53 mg/kg Eye: Lacrimation

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Respiratory depression 		ARZNAD 33,1016,1983
intravenous
rabbit 		lowest published lethal dose: 1,100 µg/kg Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Cyanosis

Gastrointestinal: Changes in structure or function of salivary glands 		PSEBAA 51,281,1942
oral
mouse 		lethal dose (50 percent kill): 3,900 mg/kg Eye: Lacrimation

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Respiratory depression 		ARZNAD 33,1016,1983
oral
rat 		lethal dose (50 percent kill): 3,400 mg/kg Eye: Chromodacryorrhea

Behavioral: Excitement

Lung, Thorax, or Respiration: Respiratory depression 		PSEBAA 58,87,1945
rectal
rabbit 		lowest published lethal dose: 1 gm/kg Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Cyanosis

Gastrointestinal: Changes in structure or function of salivary glands 		PSEBAA 51,281,1942
subcutaneous
mouse 		lowest published lethal dose: 735 mg/kg N/R JPETAB 6,477,1914/1915
subcutaneous
rabbit 		lowest published lethal dose: 1 gm/kg N/R PSEBAA 51,281,1942
unreported route
frog 		lowest published lethal dose: 1,500 mg/kg N/R PSEBAA 51,281,1942


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
rat 		lowest published toxic dose: 4,950 mg/kg/30 day- intermittent Lung, Thorax, or Respiration: Changes in lung weight

Liver: Changes in liver weight

Endocrine: Changes in thymus weight 		JOBSDN 10,29,1986
intraperitoneal
rat 		lowest published toxic dose: 6,250 mg/kg/10 week- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field INHEAO 23,135,1985
intraperitoneal
rat 		lowest published toxic dose: 3,564 mg/kg/5 week- intermittent Liver: Changes in liver weight

Endocrine: Changes in thymus weight

Blood: Changes in spleen 		IJEBA6 24,91,1986
oral
rat 		lowest published toxic dose: 331 mg/kg/14 week- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain PSEBAA 58,212,1945


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - RUSSIA short term exposure limit 0.2 mg/m3, JAN1993


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 19130;
Number of Industries 3;
Total Number of Facilities 198;
Number of Occupations 12;
Total Number of Employees Exposed 2,813
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 19130;
Number of Industries 10;
Total Number of Facilities 2,227;
Number of Occupations 30;
Total Number of Employees Exposed 31,203;
Total Number of Female Employees Exposed 8,214


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Inconclusive: E coli polA without S9
EPA TSCA Section 8(b) CHEMICAL INVENTORY


REFERENCES:

CODEN
REFERENCE
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
BJMRDK Brazilian Journal of Medical and Biological Research. (Associacao Brasileira de Divulgacao Cientifica, Faculdade de Medicina de Ribeirao Preto, USP, 141000 Ribeirao Preto, SP, Brazil) V.14- 1981-
EJPHAZ European Journal of Pharmacology. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1967-
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG.
HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig, Ger. Dem. Rep.)
IJEBA6 Indian Journal of Experimental Biology. (Publications & Information Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-
INHEAO Industrial Health. (National Institute of Industrial Health, 6-21-1 Nagao, Tama-ku, Kawasaki, 213 Japan) V.1- 1963-
JIDIAQ Journal of Infectious Diseases. (Univ. of Chicago Press, Journals Div., POB 37005, Chicago, IL 60637) V.1- 1904-
JOBSDN Journal of Biosciences. (Indian Academy of Sciences, POB 8005, Bangalore 560080, India) V.1- 1979-
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04-

Used as a lipotropic agent

RTECS Compound Description:
   Mutagen

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