The Registry of Toxic Effects of Chemical Substances

Dipropylene glycol, monomethyl ether

RTECS #: JM1575000

CAS #: 34590-94-8

UPDATE: November 2004 MW: 148.23 MF: C7H16O3


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. 1,4 - Dimethyl - 3,6 - dioxa - 1 - heptanol
  2. 1 - (1 - Methyl - 2 - methoxyethoxy) - 2 - propanol
  3. 1 - (2 - Methoxyisopropoxy) - 2 - propanol
  4. Arcosolv
  5. Dipropylene glycol methyl ether
  6. Dipropylene glycol methyl ether (ACGIH:OSHA)
  1. Dowanol DPM
  2. Dowanol - 50B
  3. Kino - red
  4. Methyl dipropanol
  5. Oxybispropanol methyl ether
  6. Ucar solvent 2LM


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
human 		8 mg mild JTOTDO 2,229,1983/1984
eye
rabbit 		500 mg/24 hour mild 85JCAE -,633,1986
skin
rabbit 		500 mg open irritation test mild UCDS** 11/15/1971


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mammal (species unspecified) 		lowest published toxic concentration: 3,000 mg/m3 Behavioral: General anesthetic VCVGK* -,175,1984
oral
dog 		lethal dose (50 percent kill): 7,500 mg/kg Lung, Thorax, or Respiration: Other changes JPETAB 102,79,1951
oral
rat 		lethal dose (50 percent kill): 5,400 µL/kg N/R AMIHBC 9,509,1954
oral
rat 		lethal dose (50 percent kill): 5.5 ml/kg N/R VCVGK* -,175,1984
skin
rabbit 		lethal dose (50 percent kill): 10 mL/kg N/R AIHAAP 23,95,1962


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
guinea pig 		lowest published toxic concentration: 2,000 mg/m3/7 hour/26 week- intermittent Brain and Coverings: Other degenerative changes

Liver: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		VCVGK* -,175,1994
inhalation
monkey 		lowest published toxic concentration: 2,000 mg/m3/7 hour/26 week- intermittent Brain and Coverings: Other degenerative changes

Liver: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		VCVGK* -,175,1994
inhalation
rat 		lowest published toxic concentration: 2,000 mg/m3/7 hour/26 week- intermittent Brain and Coverings: Other degenerative changes

Liver: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		VCVGK* -,175,1994
inhalation
rabbit 		lowest published toxic concentration: 2,000 mg/m3/7 hour/26 week- intermittent Brain and Coverings: Other degenerative changes

Liver: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		VCVGK* -,175,1994
skin
rabbit 		lowest published toxic dose: 650 mL/kg/13 week- intermittent Behavioral: General anesthetic

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		AMIHBC 9,509,1954


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 100 ppm (skin) DTLVS* TLV/BEI,2003
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value short term exposure limit 150 ppm (skin) DTLVS* TLV/BEI,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 100 ppm (600 mg/m3) (skin) DTLVS* 3,96,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 100 ppm (600 mg/m3) (skin) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 100 ppm (600 mg/m3) (skin) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 100 ppm (600 mg/m3) (skin) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 100 ppm (600 mg/m3) (skin) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 100 ppm (600 mg/m3), short term exposure limit 150 ppm, Skin, JAN1993
Occupational Exposure Limit - AUSTRIA MAK 50 ppm (300 mg/m3), JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 100 ppm (606 mg/m3), short term exposure limit 150 ppm, Skin, JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 50 ppm (300 mg/m3), Skin, JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 100 ppm (600 mg/m3), short term exposure limit 150 ppm, Skin, JAN1999
Occupational Exposure Limit - FRANCE VME 100 ppm (600 mg/m3), JAN1999
Occupational Exposure Limit - GERMANY MAK 50 ppm (300 mg/m3), JAN1999
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 300 mg/m3, 2003
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 100 ppm (600 mg/m3), Skin, JAN1993
Occupational Exposure Limit - SWEDEN time-weighted average 50 ppm (300 mg/m3), short term exposure limit 75 ppm (450 mg/m3), Skin, JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 50 ppm (300 mg/m3), short term exposure limit 100 ppm (600 mg/m3), JAN1999
Occupational Exposure Limit - TURKEY time-weighted average 300 ppm (600 mg/m3), Skin, JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 50 ppm (308 mg/m3), Skin, SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

short term exposure limit 150 ppm (skin)
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
short term exposure limit 150 ppm (skin)


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO THE CHEMICAL-air 10 hour time-weighted average 100 ppm (Sk);
short term exposure limit 150 ppm (Sk) 		NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 84537;
Number of Industries 66;
Total Number of Facilities 5,594;
Number of Occupations 55;
Total Number of Employees Exposed 52,536
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 84537;
Number of Industries 123;
Total Number of Facilities 15,846;
Number of Occupations 89;
Total Number of Employees Exposed 210,740;
Total Number of Female Employees Exposed 21,792


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in antifreeze formulations, cosmetics, cleaning compounds, heat transfer fluids
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
OSHA ANALYTICAL METHOD #101


REFERENCES:

CODEN
REFERENCE
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958-
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine. (Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
JTOTDO Journal of Toxicology, Cutaneous and Ocular Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1982-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817)
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.

Used in antifreeze formulations, cosmetics, cleaning compounds, heat transfer fluids

NIOSH PROFILE (GLYCOL ETHERS), SRI, 2/77

NIOSH PROFILE (GLYCOL ETHERS), SRC, 3/82

RTECS Compound Description:
   Primary Irritant

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