The Registry of Toxic Effects of Chemical Substances

Diphenylamine, N - nitroso -

RTECS #: JJ9800000

CAS #: 86-30-6

UPDATE: August 2004 MW: 198.24 MF: C12H10N2O


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. Benzenamine, N - nitroso - N - phenyl - (9CI)
  2. Curetard A
  3. Delac J
  4. Difenylnitrosamin (Czech)
  5. Diphenyl N - nitrosoamine
  6. N,N - Diphenylnitrosamine
  7. Naugard TJB
  8. NCI - C02880
  9. Redax
  10. Retarder J
  11. Vulcalent A
  12. Vulcatard
  1. Vulcatard A
  2. Vulkalent A (Czech)
  3. Vultrol
  4. Diphenylnitrosamin (German)
  5. Diphenylnitrosamine
  6. N - Nitrosodifenylamin (Czech)
  7. Nitrosodiphenylamine
  8. N - Nitrosodiphenylamine
  9. N - Nitroso - N - phenylaniline
  10. N - Nitroso - N - phenylbenzenamine
  11. Nitrous diphenylamide


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		500 mg/24 hour mild 85JCAE -,509,1986


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis hamster lung 62,500 µg/L MUREAV 241,175,1990
cytogenetic analysis hamster fibroblast 30 mg/L/48 hour MUREAV 48,337,1977
DNA damage Bacillus subtilis 2 mg/disc PMRSDJ 1,175,1981
DNA damage human fibroblast 3 mmol/L ENMUDM 7,267,1985
DNA damage rat liver 300 µmol/L CNREA8 42,2592,1982
DNA repair Escherichia coli 36,800 µmol/L MUREAV 272,145,1992
DNA repair Saccharomyes cerevisiae 100 mg/L PMRSDJ 1,502,1981
unscheduled DNA synthesis rat liver 500 µmol/L CNREA8 42,3010,1982
host-mediated assay mouse
Escherichia coli 		3 gm/kg MUREAV 272,161,1992
mutation in microorganisms mouse lymphocyte 100 mg/L/4 hour (+enzymatic activation step) MUREAV 59,61,1979
mutation in microorganisms Salmonella typhimurium 1,000 µg/plate (+enzymatic activation step) PMRSDJ 1,249,1981
mutation in microorganisms Salmonella typhimurium 50 µg/plate (-enzymatic activation step) CANCAR 49,1970,1982
mutation in microorganisms Salmonella typhimurium 2,500 mg/L/72 hour (+/-enzymatic activation step) MUREAV 558,181,2004
mutation in microorganisms Saccharomyes cerevisiae 89 mg/L (-enzymatic activation step) PMRSDJ 1,414,1981
morphological transform hamster embryo 6,300 µg/L CRNGDP 2,679,1981
morphological transform hamster kidney 97 mg/L PMRSDJ 1,626,1981
morphological transform hamster embryo 6,300 µg/L NCIMAV 58,243,1981
morphological transform mouse embryo 25 mg/L EMMUEG 12,21,1988
morphological transform rat embryo 1,500 µg/L JJIND8 67,1303,1981
sister chromatid exchange hamster fibroblast 100 µmol/L JNCIAM 58,1635,1977
sex chromosome loss and nondisjunction Saccharomyes cerevisiae 500 mg/L PMRSDJ 1,468,1981
specific locus test oral
Drosophila melanogaster 		10 µmol/vial MUREAV 252,119,1991


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
rat 		toxic dose : 7,700 mg/kg/77 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors

Endocrine: Tumors 		IMEMDT 27,213,1982
oral
mouse 		toxic dose : 1,750 gm/kg/2 year- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Kidney, Ureter, and Bladder: Bladder tumors 		IMEMDT 27,213,1982
oral
rat 		lowest published toxic dose: 140 gm/kg/2 year- continuous Tumorigenic: Carcinogenic by RTECS criteria

Kidney, Ureter, and Bladder: Bladder tumors 		NCITR* NCI-TR-164,1979
oral
rat 		toxic dose : 170 gm/kg/2 year- continuous Tumorigenic: Carcinogenic by RTECS criteria

Kidney, Ureter, and Bladder: Bladder tumors 		NCITR* NCI-TR-164,1979
oral
rat 		toxic dose : 2,800 gm/kg/2 year- continuous Tumorigenic: Carcinogenic by RTECS criteria

Kidney, Ureter, and Bladder: Bladder tumors

Skin and Appendages: Tumors 		IMEMDT 27,213,1982
oral
rat 		toxic dose : 146 gm/kg/2 year- continuous Tumorigenic: Carcinogenic by RTECS criteria

Kidney, Ureter, and Bladder: Bladder tumors 		EESADV 3,29,1979
skin
mouse 		lowest published toxic dose: 800 mg/kg/20 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Bronchogenic carcinoma

Tumorigenic: Increased incidence of tumors in susceptible strains 		EJCAAH 16,695,1980
skin
mouse 		toxic dose : 800 mg/kg/20 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors 		IMEMDT 27,213,1982


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lethal dose (50 percent kill): 1 gm/kg N/R PMRSDJ 1,682,1981
oral
mouse 		lethal dose (50 percent kill): 1,860 mg/kg Lung, Thorax, or Respiration: Cyanosis GISAAA 45(1),18,1980
oral
rat 		lethal dose (50 percent kill): 1,825 mg/kg Lung, Thorax, or Respiration: Cyanosis GISAAA 45(1),18,1980
skin
rabbit 		lethal dose (50 percent kill): >7,940 mg/kg Behavioral: Food intake (animal)

Behavioral: Change in motor activity (specific assay) 		ATDAEI 1,64,1990
unreported route
rat 		lethal dose (50 percent kill): 3 gm/kg N/R GMCRDC 17,107,1975


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rabbit 		lowest published toxic dose: 2,440 mg/kg/17 week- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain GTPZAB 10(4),60,1966


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
International Agency for Research on Cancer (IARC) Cancer Review Animal Limited Evidence IMEMDT 27,213,1982
International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Data IMEMDT 27,213,1982
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMSUDL 7,56,1987


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 82865;
Number of Industries 3;
Total Number of Facilities 102;
Number of Occupations 19;
Total Number of Employees Exposed 3,163
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 82865;
Number of Industries 1;
Total Number of Facilities 137;
Number of Occupations 1;
Total Number of Employees Exposed 1,093


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
ATSDR TOXICOLOGY PROFILE (NTIS** PB/93/182509/AS)
EPA GENETOX PROGRAM 1988, Positive: SHE-clonal assay; Cell transform.-RLV F344 rat embryo
EPA GENETOX PROGRAM 1988, Positive/limited: Carcinogenicity-mouse/rat
EPA GENETOX PROGRAM 1988, Negative: Cell transform.-BALB/c-3T3; Host-mediated assay
EPA GENETOX PROGRAM 1988, Negative: E coli polA with S9; Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Negative: Sperm morphology-mouse; In vitro UDS-human fibroblast
EPA GENETOX PROGRAM 1988, Negative: In vitro UDS in rat liver; V79 cell culture-gene mutation
EPA GENETOX PROGRAM 1988, Negative: S cerevisiae-homozygosis
EPA GENETOX PROGRAM 1988, Inconclusive: L5178Y cells in vitro-TK test; Mammalian micronucleus
EPA GENETOX PROGRAM 1988, Inconclusive: E coli polA without S9; In vitro SCE-nonhuman
EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster Sex-linked lethal
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in the manufacture of plastics, resins, rubber and synthetic textiles
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Bioassay (feed);clear evidence:rat NCITR* NCI-TR-164,1979
NCI Carcinogenesis Bioassay (feed);no evidence:mouse NCITR* NCI-TR-164,1979
OSHA ANALYTICAL METHOD #23


REFERENCES:

CODEN
REFERENCE
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
ATDAEI Acute Toxicity Data. Journal of the American College of Toxicology, Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1- 1990-
CANCAR Cancer (Philadelphia). (Lippincott/Harper, Journal Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1- 1948-
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941-
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
EESADV Ecotoxicology and Environmental Safety. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1977-
EJCAAH European Journal of Cancer (Elsevier Science, P.O.Box 7247-7682,Philadelphia,PA 19170 -7682,USA OR Elsevier Science B.V.,P.O.Box 1270,1000 BG Amsterdam,The Netherlands) V. 1- 1965-
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG.
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
GMCRDC Gann Monograph on Cancer Research. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No. 11- 1971-
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979-
JJIND8 JNCI, Journal of the National Cancer Institute. (Washington, DC) V.61-79, 1978-87. For publisher information, see JNCIEQ.
JNCIAM Journal of the National Cancer Institute. (Washington, DC) V.1-60, 1940-78. For publisher information, see JJIND8.
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NCIMAV National Cancer Institute, Monograph. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) No.1- 1959-
NCITR* National Cancer Institute Carcinogenesis Technical Report Series. (Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
PMRSDJ Progress in Mutation Research. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1981-

Used in the manufacture of plastics, resins, rubber and synthetic textiles

RTECS Compound Description:
   Tumorigen
   Mutagen
   Primary Irritant

 Click Here for Additional Information about RTECS