The Registry of Toxic Effects of Chemical Substances

1,3 - Dioxolane - 4 - methanol, 2,2 - dimethyl -

RTECS #: JI0400000

CAS #: 100-79-8

UPDATE: October 1997 MW: 132.18 MF: C6H12O3


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. ACUTE TOXICITY DATA:
  5. STATUS IN FEDERAL AGENCIES:
  6. REFERENCES:

SYNONYMS:

  1. Acetone, cyclic (hydroxymethyl) ethylene acetal
  2. Acetone glycerol
  3. 2,2 - Dimethyl - 1,3 - dioxolane - 4 - methanol
  4. 2,2 - Dimethyl - 4 - oxymethyl - 1,3 - dioxolane
  5. Dioxolan
  6. 2,2 - Dimethyl - 5 - hydroxymethyl - 1,3 - dioxolane
  7. GIE
  1. Glycerolacetone
  2. Glycerol dimethylketal
  3. Glycerol, 1,2 - O - isopropylidene
  4. 4 - Hydroxymethyl - 2,2 - dimethyl - 1,3 - dioxolane
  5. Isopropylidene glycerol
  6. Solketal


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		100 mg N/R TXAPA9 39,129,1977


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
micronucleus test intraperitoneal
mouse 		1,500 mg/kg TOLED5 21,349,1984


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
rat 		lethal dose (50 percent kill): 3 gm/kg N/R 85KYAH 11,820,1989
intravenous
rat 		lowest published lethal dose: 3,740 µg/kg Cardiac: Change in rate

Vascular: BP elevation not characterized in autonomic section

Vascular: BP lowering not characterized in autonomic section 		DECRDP 9,895,1983
intravenous
rabbit 		lowest published lethal dose: 8,530 µg/kg Cardiac: Change in rate

Vascular: BP elevation not characterized in autonomic section

Vascular: BP lowering not characterized in autonomic section 		DECRDP 9,895,1983
oral
rat 		lethal dose (50 percent kill): 7 gm/kg N/R 85KYAH 11,820,1989


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
N/R N/R N/R


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
85KYAH "Merck Index; an Encyclopedia of Chemicals, Drugs, and Biologicals", 11th ed., Rahway, NJ 07065, Merck & Co., Inc. 1989
DECRDP Drugs under Experimental and Clinical Research. (Bioscience Ediprint, Blvd. James-Fazy 13, 1201 Geneva 1, Switzerland) V.1- 1977-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-

RTECS Compound Description:
   Drug
   Mutagen
   Primary Irritant

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