The Registry of Toxic Effects of Chemical Substances

Dimethylamine

RTECS #: IP8750000

CAS #: 124-40-3

UPDATE: November 2004 MW: 45.10 MF: C2H7N


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. Dimethylamine (ACGIH:OSHA)
  2. Methanamine, N - methyl - (9CI)
  1. N - Methylmethanamine
  2. RCRA waste number U092


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		50 mg/5 minute N/R BJIMAG 23,153,1966


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis hamster ovary 10 mmol/L MOTOEX 1,217,1987
cytogenetic analysis inhalation
rat 		50 µg/m3 GISAAA 36(11),9,1971
sister chromatid exchange hamster ovary 500 µmol/L MOTOEX 1,217,1987


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mammal (species unspecified) 		lethal concentration (50 percent kill): 3,700 mg/m3 N/R TPKVAL 14,80,1975
inhalation
mouse 		lethal concentration (50 percent kill): 4,725 ppm/2 hour N/R AIHAAP 43,411,1982
inhalation
rat 		lethal concentration (50 percent kill): 4,540 ppm/6 hour Olfaction: Other olfaction effects

Eye: Other eye effects

Lung, Thorax, or Respiration: Dyspnea 		AIHAAP 43,411,1982
intraperitoneal
mouse 		lethal dose (50 percent kill): 736 mg/kg N/R YKKZAJ 97,1117,1977
intravenous
rabbit 		lowest published lethal dose: 4 gm/kg N/R 85KYAH 11,509,1989
oral
guinea pig 		lethal dose (50 percent kill): 240 mg/kg Behavioral: Excitement

Behavioral: Muscle weakness

Gastrointestinal: Ulceration or bleeding from stomach 		HYSAAV 32(6),329,1967
oral
mouse 		lethal dose (50 percent kill): 316 mg/kg Behavioral: Excitement

Behavioral: Muscle weakness

Gastrointestinal: Ulceration or bleeding from stomach 		HYSAAV 32(6),329,1967
oral
mouse 		lowest published toxic dose: 600 mg/kg Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field MUREAV 539,65,2003
oral
rat 		lethal dose (50 percent kill): 698 mg/kg Behavioral: Excitement

Behavioral: Muscle weakness

Gastrointestinal: Ulceration or bleeding from stomach 		HYSAAV 32(6),329,1967
oral
rabbit 		lethal dose (50 percent kill): 240 mg/kg Behavioral: Excitement

Behavioral: Muscle weakness

Gastrointestinal: Ulceration or bleeding from stomach 		HYSAAV 32(6),329,1967


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mouse 		lowest published toxic dose: 175 ppm/6 hour/1 year- intermittent Olfaction: Other olfaction effects

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		FAATDF 5,341,1985
inhalation
mouse 		lowest published toxic concentration: 175 ppm/6 hour/2 year- intermittent Olfaction: Other olfaction effects

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		TOXID9 3,24,1983
inhalation
rat 		lowest published toxic concentration: 175 ppm/6 hour/1 year- intermittent Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases 		FAATDF 5,341,1985
inhalation
rat 		lowest published toxic concentration: 175 ppm/6 hour/9 day- intermittent Olfaction: Other olfaction effects TXAPA9 90,359,1987
inhalation
rat 		lowest published toxic concentration: 175 ppm/6 hour/2 year- intermittent Olfaction: Other olfaction effects

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		TOXID9 3,24,1983
oral
guinea pig 		lowest published toxic dose: 850 mg/kg/35 week- intermittent Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Other changes in urine composition

Endocrine: Other changes 		GISAAA 32(6),12,1967
oral
rat 		lowest published toxic dose: 85 mg/kg/35 week- intermittent Behavioral: Alteration of classical conditioning

Liver: Changes in liver weight

Immunological Including Allergic: Decrease in cellular immune response 		GISAAA 32(6),12,1967
oral
rat 		lowest published toxic dose: 37,128 gm/kg/39 week- continuous Liver: Changes in liver weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) 		TOLED5 17,125,1983


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 5 ppm DTLVS* TLV/BEI,2003
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not Classifiable as a Human Carcinogen DTLVS* TLV/BEI,2003
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value STEl 15 ppm DTLVS* TLV/BEI,2003
TOXICOLOGY REVIEW
CHREAY 9,389,1931


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 10 ppm (18 mg/m3) DTLVS* 3,88,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 10 ppm (18 mg/m3) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 10 ppm (18 mg/m3) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 10 ppm (18 mg/m3) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 10 ppm (18 mg/m3) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 10 ppm (18 mg/m3), JAN1993
Occupational Exposure Limit - AUSTRIA MAK 10 ppm (18 mg/m3), JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 10 ppm (18 mg/m3), JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 10 ppm (18 mg/m3), JAN1999
Occupational Exposure Limit - FINLAND short term exposure limit 10 ppm (18 mg/m3), Skin, JAN1999
Occupational Exposure Limit - FRANCE VLE 10 ppm (18 mg/m3), JAN1999
Occupational Exposure Limit - GERMANY MAK 2 ppm (4 mg/m3), JAN1999
Occupational Exposure Limit - HUNGARY time-weighted average 1 mg/m3, short term exposure limit 2 mg/m3, Skin, JAN1993
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 1.8 mg/m3, 2003
Occupational Exposure Limit - NORWAY time-weighted average 10 ppm (18 mg/m3), JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 10 ppm (18 mg/m3), JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 9 mg/m3, MAC(short term exposure limit) 18 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA time-weighted average 10 ppm, short term exposure limit 1 mg/m3, Skin, JAN1993
Occupational Exposure Limit - SWITZERLAND MAK- week2 ppm (4 mg/m3), KZG- week 4 ppm (8 mg/m3), JAN1999
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 2 ppm (3.8 mg/m3), short term exposure limit 6 ppm (11 mg/m3), SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

STEl 15 ppm
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
STEl 15 ppm


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO DIMETHYLAMINE-air 10 hour time-weighted average 10 ppm NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 26130;
Number of Industries 13;
Total Number of Facilities 291;
Number of Occupations 16;
Total Number of Employees Exposed 3,174
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X1555;
Number of Industries 1;
Total Number of Facilities 32;
Number of Occupations 1;
Total Number of Employees Exposed 65;
Total Number of Female Employees Exposed 65
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 26130;
Number of Industries 22;
Total Number of Facilities 1,406;
Number of Occupations 42;
Total Number of Employees Exposed 28,879;
Total Number of Female Employees Exposed 2,001


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Negative: Host-mediated assay
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Amines, aliphatic, 2010
OSHA ANALYTICAL METHOD #34


REFERENCES:

CODEN
REFERENCE
85KYAH "Merck Index; an Encyclopedia of Chemicals, Drugs, and Biologicals", 11th ed., Rahway, NJ 07065, Merck & Co., Inc. 1989
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958-
BJIMAG British Journal of Industrial Medicine. (British Medical Journal, Box 560B, Kennebunkport, ME 04046) V.1- 1944-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CHREAY Chemical Reviews. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1924-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
HYSAAV Hygiene and Sanitation (USSR). English translation of GISAAA. (Springfield, VA) 1964-71. Discontinued.
MOTOEX Molecular Toxicology. (Taylor & Francis, Inc., 242 Cherry St., Philadelphia, PA USA 19106) V.1- 1987-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
YKKZAJ Yakugaku Zasshi. Journal of Pharmacy. (Nippon Yakugakkai, 2-12-15 Shibuya, Shibuya-ku, Tokyo 150, Japan) No.1- 1881-

NIOSH PROFILE (AMINES, SECONDARY ALIPHATIC), SRI, 2/77

RTECS Compound Description:
   Mutagen
   Primary Irritant

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