UPDATE: May 2005 | MW: 380.90 | MF: C12H8Cl6O |
SYNONYMS:
|
|
|
SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
|
| EFFECT
REFERENCE
|
N/R |
N/R
|
N/R
|
N/R
|
|
MUTATION DATA AND REFERENCES:
SYSTEM TEST
|
ROUTE/ | ORGANISM/ TISSUE
DOSE
|
REFERENCE
|
cytogenetic analysis
|
parenteral | rat
1 mg/kg
|
BECTA6 9,65,1973
|
sister chromatid exchange
|
multiple | other fish
54 pmol/L
|
MUREAV 118,61,1983
|
sperm morphology
|
parenteral | rat
10 mg/kg/10 day- continuous
|
APTOA6 31,1,1972
|
|
REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
|
| EFFECT
REFERENCE
|
intratesticular | rat
lowest published toxic dose: 10 mg/kg (10 day male)
|
Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)
|
APTOA6 31,1,1972
|
oral | hamster
lowest published toxic dose: 15 mg/kg (5-14 day pregnant)
|
Reproductive: Effects on newborn: Behavioral
|
TXCYAC 21,187,1981
|
oral | hamster
lowest published toxic dose: 5 mg/kg (8 day pregnant)
|
Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) | Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) Reproductive: Effects on embryo or fetus: Fetal death
TJADAB 9,11,1974
|
oral | hamster
lowest published toxic dose: 5 mg/kg (8 day pregnant)
|
Reproductive: Specific developmental abnormalities: Eye, ear | Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue) Reproductive: Specific developmental abnormalities: Musculoskeletal system
TJADAB 9,11,1974
|
oral | hamster
lowest published toxic dose: 7,500 µg/kg (5-14 day pregnant)
|
Reproductive: Effects on newborn: Weaning or lactation index (e.g., # alive at weaning per # alive at day 4)
|
TXAPA9 48,A200,1979
|
oral | hamster
lowest published toxic dose: 5 mg/kg (8 day pregnant)
|
Reproductive: Specific developmental abnormalities: Central nervous system | Reproductive: Specific developmental abnormalities: Musculoskeletal system
TXAPA9 48,A201,1979
|
oral | mouse
lowest published toxic dose: 10 mg/kg (8-12 day pregnant)
|
Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
|
JTEHD6 10,541,1982
|
oral | mouse
lowest published toxic dose: 2,500 µg/kg (9 day pregnant)
|
Reproductive: Specific developmental abnormalities: Eye, ear
|
TJADAB 9,11,1974
|
oral | mouse
lowest published toxic dose: 2,320 µg/kg (4 day prior to copulation)
|
Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea) | Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)
OYYAA2 6,673,1972
|
oral | mouse
lowest published toxic dose: 7 mg/kg (8 day pregnant)
|
Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) | Reproductive: Specific developmental abnormalities: Musculoskeletal system
TCMUD8 5,3,1985
|
oral | mouse
lowest published toxic dose: 16,500 µg/kg (7-17 day pregnant)
|
Reproductive: Specific developmental abnormalities: Urogenital system
|
TXCYAC 21,141,1981
|
oral | rat
lowest published toxic dose: 2,320 µg/kg (4 day prior to copulation)
|
Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea) | Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) Reproductive: Specific developmental abnormalities: Musculoskeletal system
OYYAA2 6,673,1972
|
|
TUMORIGENIC DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
|
| EFFECT
REFERENCE
|
N/R |
N/R
|
N/R
|
N/R
|
|
ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
|
| EFFECT
REFERENCE
|
intracerebral | mouse
lethal dose (50 percent kill): 400 µg/kg
|
Behavioral: Convulsions or effect on seizure threshold
|
TOLED5 60,289,1992
|
intraperitoneal | mouse
lethal dose (50 percent kill): 5 mg/kg
|
N/R
|
TOLED5 60,289,1992
|
intravenous | mouse
lethal dose (50 percent kill): 2,300 µg/kg
|
N/R
|
TXAPA9 23,408,1972
|
intravenous | pigeon
lethal dose (50 percent kill): 1,500 µg/kg
|
Behavioral: Convulsions or effect on seizure threshold
|
TXAPA9 9,75,1966
|
oral | wild bird
lethal dose (50 percent kill): 1,780 µg/kg
|
N/R
|
ASTTA8 (680),157,1979
|
oral | cat
lowest published lethal dose: 5 mg/kg
|
Behavioral: Ataxia | Lung, Thorax, or Respiration: Dyspnea Lung, Thorax, or Respiration: Cyanosis
JAFCAU 3,842,1955
|
oral | chicken
lowest published lethal dose: 2 mg/kg
|
Behavioral: Ataxia | Behavioral: Irritability
CNVJA9 11,74,1970
|
oral | duck
lethal dose (50 percent kill): 5,330 µg/kg
|
N/R
|
TXAPA9 22,556,1972
|
oral | guinea pig
lethal dose (50 percent kill): 16 mg/kg
|
N/R
|
PCOC** -,475,1966
|
oral | hamster
lethal dose (50 percent kill): 10 mg/kg
|
N/R
|
TJADAB 9,11,1974
|
oral | man
lowest published lethal dose: 171 mg/kg
|
Behavioral: Convulsions or effect on seizure threshold | Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) Blood: Thrombocytopenia
HUTODJ 4,241,1985
|
oral | monkey
lethal dose (50 percent kill): 3 mg/kg
|
N/R
|
PCOC** -,475,1966
|
oral | mouse
lethal dose (50 percent kill): 1,370 µg/kg
|
N/R
|
TXAPA9 25,42,1973
|
oral | mouse
lowest published toxic dose: 137 µg/kg
|
Brain and Coverings: Other degenerative changes | Liver: Other changes Biochemical: Metabolism (intermediary): Lipids including transport
TXCYAC 175,73,2002
|
oral | pigeon
lethal dose (50 percent kill): 5,600 µg/kg
|
N/R
|
TXAPA9 21,315,1972
|
oral | quail
lethal dose (50 percent kill): 4,210 µg/kg
|
N/R
|
ASTTA8 (680),157,1979
|
oral | rat
lethal dose (50 percent kill): 3 mg/kg
|
N/R
|
WRPCA2 9,119,1970
|
oral | rabbit
lethal dose (50 percent kill): 7 mg/kg
|
Behavioral: Ataxia | Lung, Thorax, or Respiration: Dyspnea Lung, Thorax, or Respiration: Cyanosis
JAFCAU 3,842,1955
|
oral | woman
lowest published lethal dose: 234 mg/kg
|
Behavioral: Headache | Lung, Thorax, or Respiration: Dyspnea Nutritional and Gross Metabolic: Body temperature increase
NEZAAQ 22,254,1967
|
skin | cat
lowest published lethal dose: 75 mg/kg
|
Behavioral: Food intake (animal) | Behavioral: Withdrawal Gastrointestinal: Nausea or vomiting
CVETAA 2,71,1958
|
skin | rat
lethal dose (50 percent kill): 12 mg/kg
|
N/R
|
SPEADM 78-1,13,1978
|
skin | rabbit
lethal dose (50 percent kill): 60 mg/kg
|
N/R
|
SPEADM 78-1,13,1978
|
unreported route | rat
lethal dose (50 percent kill): 17 mg/kg
|
N/R
|
30ZDA9 -,64,1971
|
unreported route | rabbit
lethal dose (50 percent kill): 7 mg/kg
|
N/R
|
30ZDA9 -,64,1971
|
|
OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
|
| EFFECT
REFERENCE
|
inhalation | mouse
lowest published toxic concentration: 360 ppb/7 hour/22 week- intermittent
|
Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
|
JAFCAU 3,842,1955
|
inhalation | rabbit
lowest published toxic concentration: 360 ppb/7 hour/24 week- intermittent
|
Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
|
JAFCAU 3,842,1955
|
oral | dog
lowest published toxic dose: 12,150 µg/kg/81 week- intermittent
|
Cardiac: Changes in heart weight | Kidney, Ureter, and Bladder: Changes in bladder weight
JAFCAU 3,842,1955
|
oral | rat
lowest published toxic dose: 1,975 mg/kg/79 day- intermittent
|
Eye: Hemorrhage | Behavioral: Excitement Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TXAPA9 14,556,1969
|
oral | rat
lowest published toxic dose: 219 mg/kg/2 year- continuous
|
Liver: Changes in liver weight | Nutritional and Gross Metabolic: Other changes
JAFCAU 3,842,1955
|
oral | rat
lowest published toxic dose: 6,720 mg/kg/16 week- continuous
|
Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
JAFCAU 4,696,1956
|
oral | rabbit
lowest published toxic dose: 50 mg/kg/72 day- intermittent
|
Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
|
JAFCAU 3,842,1955
|
skin | rabbit
lowest published toxic dose: 1,400 mg/kg/14 week- intermittent
|
Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
|
JAFCAU 3,842,1955
|
|
REVIEWS:
ORGANIZATION
|
STANDARD
|
|
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
|
time-weighted average 0.1 mg/m3 (skin)
|
DTLVS* TLV/BEI,2003
|
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
|
Not Classifiable as a Human Carcinogen
|
DTLVS* TLV/BEI,2003
|
International Agency for Research on Cancer (IARC) Cancer Review
|
Animal Inadequate Evidence
|
IMEMDT 5,157,1974
|
International Agency for Research on Cancer (IARC) Cancer Review
|
Human No Adequate Data
|
IMEMDT 5,157,1974
|
International Agency for Research on Cancer (IARC) Cancer Review
|
Group 3
|
IMSUDL 7,56,1987
|
TOXICOLOGY REVIEW
|
|
TOLED5 127,101,2002
|
TOXICOLOGY REVIEW
|
|
BECTA6 15,283,1976
|
TOXICOLOGY REVIEW
|
|
CNDQA8 10(3),43,1975
|
TOXICOLOGY REVIEW
|
|
RREVAH 56,107,1975
|
TOXICOLOGY REVIEW
|
|
BNYMAM 54,413,1978
|
TOXICOLOGY REVIEW
|
|
CTOXAO 13,231,1978
|
TOXICOLOGY REVIEW
|
|
26UZAB 6,149,1968/1970
|
TOXICOLOGY REVIEW
|
|
MUREAV 567,109,2004
|
|
STANDARDS AND REGULATIONS:
ORGANIZATION
|
STANDARD
|
|
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988
|
PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION
|
FEREAC 54,7740,1989
|
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF
|
PESTICIDES: Cancelled
|
RBREV* -,180,1998
|
Mine Safety and Health Administration (MSHA) STANDARD - air
|
time-weighted average 0.1 mg/m3 (skin)
|
DTLVS* 3,98,1971
|
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)
|
8 hour time-weighted average 0.1 mg/m3 (skin)
|
CFRGBR 29,1910.1000,1994
|
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)
|
8 hour time-weighted average 0.1 mg/m3 (skin)
|
CFRGBR 29,1926.55,1994
|
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)
|
8 hour time-weighted average 0.1 mg/m3 (skin)
|
CFRGBR 29,1915.1000,1993
|
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)
|
8 hour time-weighted average 0.1 mg/m3 (skin)
|
CFRGBR 41,50-204.50,1994
|
Occupational Exposure Limit - ARAB Republic of Egypt
|
time-weighted average 0.1 mg/m3, Skin, JAN1993
|
Occupational Exposure Limit - AUSTRALIA
|
time-weighted average 0.1 mg/m3, Skin, JAN1993
|
Occupational Exposure Limit - AUSTRIA
|
MAK 0.1 mg/m3, Skin, JAN1999
|
Occupational Exposure Limit - BELGIUM
|
time-weighted average 0.1 mg/m3, Skin, JAN1993
|
Occupational Exposure Limit - DENMARK
|
time-weighted average 0.1 mg/m3, Skin, JAN1999
|
Occupational Exposure Limit - FINLAND
|
time-weighted average 0.1 mg/m3, short term exposure limit 0.3 mg/m3, Skin, JAN1999
|
Occupational Exposure Limit - FRANCE
|
VME 0.1 mg/m3, Skin, JAN1999
|
Occupational Exposure Limit - GERMANY
|
MAK 0.1 mg/m3, Skin, JAN1999
|
Occupational Exposure Limit - THE NETHERLANDS
|
MAC-TGG 0.1 mg/m3, Skin, 2003
|
Occupational Exposure Limit - NORWAY
|
time-weighted average 0.1 mg/m3, JAN1999
|
Occupational Exposure Limit - POLAND
|
MAC(time-weighted average) 0.5 mg/m3, MAC(short term exposure limit) 1.5 mg/m3, JAN1999
|
Occupational Exposure Limit - SWITZERLAND
|
MAK- week 0.1 mg/m3, Skin, JAN1999
|
Occupational Exposure Limit - THAILAND
|
time-weighted average 0.1 mg/m3, JAN1993
|
Occupational Exposure Limit - TURKEY
|
time-weighted average 0.1 mg/m3, Skin, JAN1993
|
Occupational Exposure Limit - UNITED KINGDOM
|
time-weighted average 0.1 mg/m3, short term exposure limit 0.3 mg/m3, Skin, SEP2000
|
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA
|
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value; | Not Classifiable as a Human Carcinogen
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM
|
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value |
Not Classifiable as a Human Carcinogen |
NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION
|
STANDARD or SURVEY
|
|
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ENDRIN-air
|
10 hour time-weighted average 0.1 mg/m3 (Sk)
|
NIOSH* DHHS #92-100,1992
|
|
STATUS IN FEDERAL AGENCIES:
ORGANIZATION
|
|
REFERENCE
EPA GENETOX PROGRAM 1988, Negative: Histidine reversion-Ames test
|
EPA GENETOX PROGRAM 1988, Negative: In vitro UDS-human fibroblast; TRP reversion
|
EPA GENETOX PROGRAM 1988, Negative: S cerevisiae-homozygosis
|
EPA GENETOX PROGRAM 1988, Negative/limited: Carcinogenicity-mouse/rat
|
EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster Sex-linked lethal
|
Used as an insecticide, avicide, and rodenticide
|
EPA TSCA Section 8(d) unpublished health/safety studies
|
On EPA IRIS database
|
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
|
NIOSH Analytical Method, 1994: Endrin, 5519
|
NCI Carcinogenesis Bioassay (feed);no evidence:mouse,rat
|
NCITR* NCI-TR-12,1979
|
|
REFERENCES:
CODEN
|
|
REFERENCE
26UZAB
|
"Pesticides Symposia; Collection of Papers Presented at the Sixth & Seventh Inter-American
Conferences on Toxicology and Occupational Medicine, Miami, FL," Miami, FL, J.L. Halos,
1968-70
|
30ZDA9
|
"Chemistry of Pesticides," Melnikov, N.N., New York, Springer-Verlag New York, Inc., 1971
|
APTOA6
|
Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher
information, see PHTOEH
|
ASTTA8
|
ASTM Special Technical Publication. (American Soc. for Testing Materials, 1916 Race St.,
Philadelphia, PA 19103) No.1- 1911-
|
BECTA6
|
Bulletin of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc.,
Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1966-
|
BNYMAM
|
Bulletin of the New York Academy of Medicine. (New York Academy of Medicine, 2 E. 103rd St.,
New York, NY 10029) Ser 2: V.1- 1925-
|
CFRGBR
|
Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents,
Washington, DC 20402)
|
CNDQA8
|
Cahiers de Nutrition et de Dietetique. (Editions Meteore, 42, rue du Louvre, 75001 Paris,
France) V.1- 1966-
|
CNVJA9
|
Canadian Veterinary Journal. (339 Booth St., Ottawa, ON K1R 6J3, Canada) V.1- 1960-
|
CTOXAO
|
Clinical Toxicology. (New York, NY) V.1-18, 1968-81. For publisher information, see JTCTDW.
|
CVETAA
|
Communicationes Veterinariae. (Bogor, Indonesia) V.1-9, 1957-65. Discontinued.
|
DTLVS*
|
The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by
American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
|
FEREAC
|
Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
V.1- 1936-
|
HUTODJ
|
Human Toxicology. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants., RG 21 2XS, UK) V.1-
1981-
|
IMEMDT
|
IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications
Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
|
IMSUDL
|
IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210) No.1- 1979-
|
JAFCAU
|
Journal of Agricultural and Food Chemistry. (American Chemical Soc., Distribution Office
Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1953-
|
JTEHD6
|
Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW,
Washington, DC 20005) V.1- 1975/76-
|
MUREAV
|
Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1-
1964-
|
NCITR*
|
National Cancer Institute Carcinogenesis Technical Report Series. (Bethesda, MD) No.0-205.
For publisher information, see NTPTR*.
|
NEZAAQ
|
Nippon Eiseigaku Zasshi. Japanese Journal of Hygiene. (Nippon Eisei Gakkai, c/o Kyoto
Daigaku Igakubu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.1- 1946-
|
NIOSH*
|
National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and
Welfare, Reports and Memoranda.
|
OYYAA2
|
Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1-
1967-
|
PCOC**
|
Pesticide Chemicals Official Compendium, Association of the American Pesticide Control
Officials, Inc., 1966. (Topeka, KS)
|
RBREV*
|
Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report),
Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental
Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
|
RREVAH
|
Residue Reviews. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ
07094) V.1- 1962-
|
SPEADM
|
Special Publication of the Entomological Society of America. (4603 Calvert Rd., College Park,
MD 20740)
|
TCMUD8
|
Teratogenesis, Carcinogenesis, and Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New
York, NY 10003) V.1- 1980-
|
TJADAB
|
Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E.
11th St., New York, NY 10003) V.1- 1968-
|
TOLED5
|
Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands)
V.1- 1977-
|
TXAPA9
|
Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802)
V.1- 1959-
|
TXCYAC
|
Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-
|
WRPCA2
|
World Review of Pest Control. (London, UK) V.1-10, 1962-71. Discontinued.
|
|