The Registry of Toxic Effects of Chemical Substances

Diethylenetriamine

RTECS #: IE1225000

CAS #: 111-40-0

UPDATE: November 2004 MW: 103.20 MF: C4H13N3


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. 1,2 - Ethanediamine, N - (2 - aminoethyl) -
  2. 1,4,7 - Triazaheptane
  3. 2,2' - Diaminodiethylamine
  4. 2,2' - Iminobis (ethanamine)
  5. 3 - Azapentane - 1,5 - diamine
  6. Aminoethylethandiamine
  7. Bis (2 - aminoethyl) amine
  1. Bis (beta - aminoethyl) amine
  2. ChS - P 1
  3. Diethylamine, 2,2' - diamino -
  4. Diethylenetriamine (ACGIH:OSHA)
  5. Ethylamine, 2,2' - iminobis -
  6. Ethylenediamine, N - (2 - aminoethyl) -


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
skin
rabbit 		500 mg open irritation test moderate UCDS** 12/30/1971
skin
rabbit 		500 mg moderate IYKEDH 6,170,1975


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published lethal concentration: 70 mg/m3/4 hour N/R NTIS** OTS0556409
intraperitoneal
mouse 		lethal dose (50 percent kill): 71 mg/kg Behavioral: Convulsions or effect on seizure threshold

Gastrointestinal: Peritonitis 		AMIHAB 17,129,1958
intraperitoneal
rat 		lethal dose (50 percent kill): 74 mg/kg Behavioral: Convulsions or effect on seizure threshold

Gastrointestinal: Peritonitis 		AMIHAB 17,129,1958
oral
rat 		lethal dose (50 percent kill): 1,080 mg/kg Behavioral: Convulsions or effect on seizure threshold AMIHAB 17,129,1958
skin
guinea pig 		lethal dose (50 percent kill): 170 µL/kg N/R JIHTAB 26,269,1944
skin
rabbit 		lethal dose (50 percent kill): 1,090 mg/kg N/R JIHTAB 31,60,1949
unreported route
guinea pig 		lethal dose (50 percent kill): 600 mg/kg N/R GISAAA 37(7),103,1972
unreported route
mouse 		lethal dose (50 percent kill): 970 mg/kg N/R GISAAA 37(7),103,1972
unreported route
rat 		lethal dose (50 percent kill): 970 mg/kg N/R GISAAA 37(7),103,1972
unreported route
rabbit 		lethal dose (50 percent kill): 970 mg/kg N/R GISAAA 37(7),103,1972


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rabbit 		lowest published toxic dose: 1,820 mg/kg/26 week- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases GISAAA 37(7),103,1972


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 1 ppm (skin) DTLVS* TLV/BEI,2003
TOXICOLOGY REVIEW
JJOMDZ 15,808,1973


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 1 ppm (4 mg/m3) (skin) DTLWS* 3,85,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) ceiling concentration 10 ppm (42 mg/m3) (skin) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) ceiling concentration 10 ppm (42 mg/m3) (skin) CFRGBR 29,1915.1000,1993
Occupational Exposure Limit - AUSTRALIA time-weighted average 1 ppm (4 mg/m3), Skin, JAN1993
Occupational Exposure Limit - AUSTRIA MAK 1 ppm (4 mg/m3), JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 1 ppm (4.2 mg/m3), Skin, JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 1 ppm (4 mg/m3), Skin, JAN1999
Occupational Exposure Limit - FRANCE VME 1 ppm (4 mg/m3), JAN1999
Occupational Exposure Limit - HUNGARY short term exposure limit 4 mg/m3, Skin, JAN1993
Occupational Exposure Limit - NORWAY time-weighted average 1 ppm (4 mg/m3), JAN1999
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 4 mg/m3, 2003
Occupational Exposure Limit - SWITZERLAND MAK- week 1 ppm (4 mg/m3), Skin, JAN1999
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 1 ppm (4.3 mg/m3), Skin, SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 1 ppm (skin)
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 1 ppm (skin)


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO DIETHYLENE TRIAMINE-air 10 hour time-weighted average 1 ppm (Sk) NIOSH* DHHS #95-121,1995
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 25210;
Number of Industries 66;
Total Number of Facilities 2,804;
Number of Occupations 56;
Total Number of Employees Exposed 38,557
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 25210;
Number of Industries 78;
Total Number of Facilities 2,978;
Number of Occupations 74;
Total Number of Employees Exposed 94,517;
Total Number of Female Employees Exposed 15,589


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE FEREAC 47,26992,82
Used in textile finishes, fungicides, corrosion inhibitors, adhesives, asphalt additives
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Diethylenetriamine, 2540
OSHA ANALYTICAL METHOD #ID-60


REFERENCES:

CODEN
REFERENCE
AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21, 1955-60. For publisher information, see AEHLAU.
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
DTLWS* "Documentation of the Threshold Limit Values for Substances in Workroom Air," Supplements. For publisher information, see 85INA8.
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970-
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU.
JJOMDZ JOM, Journal of Occupational Medicine. (American Occupational Medicine Assoc., 150 N. Wacker Dr., Chicago, IL 60606) V.10- 1968-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817)

Used in textile finishes, fungicides, corrosion inhibitors, adhesives, asphalt additives

NIOSH PROFILE (AMINES, POLY), SRI, 2/77

RTECS Compound Description:
   Primary Irritant

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