The Registry of Toxic Effects of Chemical Substances

Diesel exhaust

RTECS #: HZ1755000

CAS #: N/R

UPDATE: November 2004 MW: N/R MF: N/R


NOTE:

TABLE OF CONTENTS:
  1. MUTATION DATA:
  2. TUMORIGENIC DATA:
  3. OTHER MULTIPLE DOSE DATA:
  4. REVIEWS:
  5. STANDARDS AND REGULATIONS:
  6. STATUS IN FEDERAL AGENCIES:
  7. REFERENCES:

SYNONYMS:

N/R N/R


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
DNA adduct inhalation
mouse 		6,200 µg/m3/16 hour/12 week- intermittent EMMUEG 16,64,1990
mutation in microorganisms Salmonella typhimurium 1 mg/plate (+/-enzymatic activation step) MUREAV 415,13,1998


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 4,900 µg/m3/8 hour/2 year- continuous Tumorigenic: Carcinogenic by RTECS criteria

Blood: Lymphoma including Hodgkin's disease 		DTESD7 13,349,1986
inhalation
rat 		toxic concentration (other than lowest) : 7 mg/m3/7 hour/2 year- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors 		FAATDF 9,208,1987
inhalation
rat 		toxic concentration (other than lowest) : 4 mg/m3/18 hour/2 year- intermittent Tumorigenic: Neoplastic by RTECS criteria

Lung, Thorax, or Respiration: Tumors 		DTESD7 13,459,1986
inhalation
rat 		toxic concentration (other than lowest) : 2,500 µg/m3/18 hour/2 year- intermittent Tumorigenic: Neoplastic by RTECS criteria

Lung, Thorax, or Respiration: Tumors 		INHTE5 7,533,1995
inhalation
rat 		lowest published toxic concentration: 274 mg/m3/2 year- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors 		INHTE5 12,97,2000
intratracheal
rat 		lowest published toxic dose: 36,400 mg/kg/2.5 year- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors 		ARDSBL 141(Suppl),A3-A937,1990


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
guinea pig 		lowest published toxic concentration: 6,300 µg/m3/20 hour/8 week- intermittent Cardiac: Pulse rate decreased with fall in BP

Lung, Thorax, or Respiration: Other changes

Lung, Thorax, or Respiration: Changes in lung weight 		ENVRAL 22,285,1980
inhalation
guinea pig 		lowest published toxic concentration: 300 µg/m3/5 week- intermittent Olfaction: Other olfaction effects AJCMED 162,352,2000
inhalation
mouse 		lowest published toxic concentration: 3 mg/m3/12 hour/34 week- intermittent Lung, Thorax, or Respiration: Other changes TOSCF2 44,70,1998
inhalation
mouse 		lowest published toxic concentration: 3,500 µg/m3/7 hour/78 week- intermittent Lung, Thorax, or Respiration: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases 		FAATDF 11,546,1988
inhalation
mouse 		lowest published toxic concentration: 6 mg/m3/12 hour/3 week- intermittent Endocrine: Changes in spleen weight

Immunological Including Allergic: Decrease in cellular immune response

Immunological Including Allergic: Increase in humoral response 		TXCYAC 116,227,1997
inhalation
rat 		lowest published toxic concentration: 3,500 µg/m3/7 hour/2 year- intermittent Lung, Thorax, or Respiration: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases 		FAATDF 11,546,1988


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 46,41,1989
International Agency for Research on Cancer (IARC) Cancer Review Human Limited Evidence IMEMDT 46,41,1989
International Agency for Research on Cancer (IARC) Cancer Review Group 2A IMEMDT 46,41,1989


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - AUSTRIA Carcinogen, JAN1999
Occupational Exposure Limit - GERMANY Carcinogen, JAN1999
Occupational Exposure Limit - SWITZERLAND 0.2 mg/m3, Carcinogen, JAN1999


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
N/R N/R N/R


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
On EPA IRIS database
NIOSH Analytical Method, 1996: Element carbon (diesel exhaust), 5040


REFERENCES:

CODEN
REFERENCE
AJCMED American Journal of Respiratory and Critical Care Medicine. (American Lung Association, 1740 Broadway, New Youk, NY 10019) V. 149- 1994-
ARDSBL American Review of Respiratory Disease. (American Lung Assoc., 1740 Broadway, New York, NY 10019) V.80- 1959-
DTESD7 Developments in Toxicology and Environtal Science. (Elsevier Science, New York, NY) V.1-15, 1977-87. Discontinued
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1967-
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
INHTE5 Inhalation Toxicology. (Published by Taylor & Francis Health, 11 New Fetter Lane, London EC4P 4EE) V.1- 1989-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
TOSCF2 Toxicological Sciences (Oxford University Press, 6277 Sea Harbor Drive, Orlando, FL 32887 ) V. 41, Jan. 1998-
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-

RTECS Compound Description:
   Tumorigen
   Mutagen

ALT CAS #: N/R
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