The Registry of Toxic Effects of Chemical Substances

Dichromic acid, disodium salt

RTECS #: HX7700000

CAS #: 10588-01-9

UPDATE: May 2005 MW: 261.98 MF: Cr2O7•2Na


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. NIOSH DOCUMENTATION AND SURVEILLANCE:
  10. STATUS IN FEDERAL AGENCIES:
  11. REFERENCES:

SYNONYMS:

  1. Bichromate de sodium (French)
  2. Bichromate of soda
  3. Disodium dichromate
  4. Natriumbichromaat (Dutch)
  5. Natriumdichromaat (Dutch)
  6. Natriumdichromat (German)
  1. Sodio (dicromato di) (Italian)
  2. Sodium bichromate
  3. Sodium dichromate (VI)
  4. Sodium dichromate
  5. Sodium (dichromate de) (French)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis hamster ovary 250 µg/L TXCYAC 17,219,1980
cytogenetic analysis hamster ovary 0.1 mg/L/30 hour MUREAV 67,231,1979
cytogenetic analysis human lymphocyte 2 µmol/L CARYAB 33,239,1980
DNA damage human other cell types 500 µmol/L/1 hour MUTAEX 16,467,2001
DNA damage human lymphocyte 50 µmol/L/1 hour MUTAEX 16,467,2001
DNA damage human lung 10 µmol/L/1 hour MUTAEX 16,467,2001
DNA damage intraperitoneal
rat 		20 mg/kg JBCHA3 256,3623,1981
DNA damage rat liver 300 µmol/L MUREAV 189,69,1987
DNA damage rat other cell types 500 µmol/L FCTOD7 31,271,1993
DNA repair Bacillus subtilis 50 mmol/L TOLED5 7,439,1981
DNA repair Escherichia coli 200 nmol/plate JTEHD6 9,287,1982
mutation in microorganisms Escherichia coli 5 µg/plate (-enzymatic activation step) MUREAV 412,17,1998
mutation in microorganisms Salmonella typhimurium 35 µg/plate (+enzymatic activation step) CRNGDP 9,611,1988
mutation in microorganisms Salmonella typhimurium 30 µg/plate (-enzymatic activation step) PCBRD2 109,453,1982
morphological transform rat other cell types 300 nmol/L MUREAV 198,115,1988
sister chromatid exchange hamster ovary 250 µg/L TXCYAC 17,219,1980


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
rat 		lowest published toxic dose: 20 mg/kg (8 week male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Other effects on male

Endocrine: Androgenic 		HETOEA 11,255,1992


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 252 µg/m3/78 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors 		TXCYAC 42,219,1986
intrapleural
rat 		lowest published toxic dose: 160 mg/kg/69 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors 		AEHLAU 5,445,1962


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
guinea pig 		lowest published lethal dose: 335 mg/kg N/R AEHLAU 11,201,1965
intravenous
frog 		lowest published lethal dose: 196 mg/kg N/R AIPTAK 62,330,1939
intravenous
mouse 		lowest published lethal dose: 26,200 µg/kg N/R EQSSDX 1,1,1975
intravenous
rabbit 		lowest published lethal dose: 18,400 µg/kg N/R EQSSDX 1,1,1975
oral
child 		lowest published lethal dose: 50 mg/kg N/R YAKUD5 22,291,1980
oral
child 		lowest published toxic dose: 250 mg/kg Lung, Thorax, or Respiration: Cough

Gastrointestinal: Nausea or vomiting

Skin and Appendages: Other: Sweating 		AUPJB7 21,65,1985
oral
mouse 		lowest published toxic dose: 19 mg/kg Brain and Coverings: Other degenerative changes

Liver: Other changes

Biochemical: Metabolism (intermediary): Lipids including transport 		TXCYAC 175,73,2002
oral
rat 		lethal dose (50 percent kill): 50 mg/kg Liver: Other changes

Kidney, Ureter, and Bladder: Other changes 		GTPZAB 22(8),38,1978
oral
rat 		lowest published toxic dose: 25 mg/kg Biochemical: Metabolism (intermediary): Lipids including transport TXCYAC 180,5,2002
subcutaneous
guinea pig 		lowest published lethal dose: 23 mg/kg N/R HBAMAK 4,1330,1935
subcutaneous
rat 		lowest published lethal dose: 80 mg/kg N/R TOXID9 4,75,1984
skin
guinea pig 		lowest published lethal dose: 335 mg/kg N/R AEHLAU 11,201,1965


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intravenous
domestic animal 		lowest published toxic dose: 3 mg/kg/5 day- continuous Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Kidney, Ureter, and Bladder: Proteinuria

Kidney, Ureter, and Bladder: Hematuria 		COVEAZ 76,306,1986
oral
dog 		lowest published toxic dose: 7,280 mg/kg/2 year- continuous Cardiac: Changes in coronary arteries GTPZAB 19(6),35,1975
oral
pig 		lowest published toxic dose: 3,438 µg/kg/39 week- continuous Cardiac: Other changes CUTOEX 1,221,1993
oral
rat 		lowest published toxic dose: 75 mg/kg/30 day- intermittent Biochemical: Metabolism (intermediary): Lipids including transport TXCYAC 180,5,2002


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.05 mg(Cr)/m3 DTLVS* TLV/BEI,1999
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Confirmed human carcinogen DTLVS* TLV/BEI,1999
International Agency for Research on Cancer (IARC) Cancer Review Human Sufficient Evidence IMEMDT 49,49,1990
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 23,205,1980
International Agency for Research on Cancer (IARC) Cancer Review Animal Limited Evidence IMEMDT 49,49,1990
International Agency for Research on Cancer (IARC) Cancer Review Animal Inadequate Evidence IMEMDT 2,100,1973
International Agency for Research on Cancer (IARC) Cancer Review Animal Inadequate Evidence IMEMDT 23,205,1980
International Agency for Research on Cancer (IARC) Cancer Review Group 1 IMEMDT 49,49,1990
TOXICOLOGY REVIEW
FCTXAV 9,105,1971
TOXICOLOGY REVIEW
85DHAX Cr,22,1974


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Supported RBREV* -,101,1998
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 0.5 mg(Cr)/m3 DTLVS* 3,35,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) ceiling concentration 0.1 mg(CrO3)/m3 CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) ceiling concentration 0.1 mg(CrO3)/m3 CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) ceiling concentration 0.1 mg(CrO3)/m3 CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) ceiling concentration 0.1 mg(CrO3)/m3 CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - UNITED KINGDOM Carcinogen, SEP2000


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO CHROMIUM(VI)-air Carcinogen;
10 hour time-weighted average 0.001 mg(Cr)/m3 		NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: M0073;
Number of Industries 85;
Total Number of Facilities 7,838;
Number of Occupations 64;
Total Number of Employees Exposed 44,269
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: M0073;
Number of Industries 118;
Total Number of Facilities 11,523;
Number of Occupations 82;
Total Number of Employees Exposed 136,313;
Total Number of Female Employees Exposed 24,542


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Positive: Histidine reversion-Ames test
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in manufacture of CHROMIC ACID and pigments, leather tanning, and corrosion control
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NTP 11th Report on Carcinogens,2004:Known to be human carcinogen


REFERENCES:

CODEN
REFERENCE
85DHAX "Medical and Biologic Effects of Environmental Pollutants Series," Washington, DC, National Academy of Sciences, 1972-77
AEHLAU Archives of Environmental Health. (Heldref Pub., 4000 Albemarle St., NW, Washington, DC 20016) V.1- 1960-
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898-
AUPJB7 Australian Paediatric Journal. (Royal Childrens Hospital, Parkville, Vic., Australia) V.1- 1965-
CARYAB Caryologia. (Via G. LaPira 4, 50121 Florence, Italy) V.1- 1948-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
COVEAZ Cornell Veterinarian. (Cornell Univ. New York State College of Veterinary Medicine, Ithaca, NY 14853) V.1- 1911-
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
CUTOEX Current Toxicology. (Nova Science Publishers, Inc., 6080 Jericho Turnpike, Suite 207, Commack, NY 11725) V.1 1993-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EQSSDX Environmental Quality and Safety, Supplement. (Stuttgart, Fed. Rep. Ger.) V.1-5, 1975-76. Discontinued.
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7.
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig, Ger. Dem. Rep.)
HETOEA Human & Experimental Toxicology. (Macmillan Press Ltd., Brunel Road, Houndmills, Basingstoke, Hampshire, RG21 2XS, UK) V.9- 1990-
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
JBCHA3 Journal of Biological Chemistry. (428 E. Preston St., Baltimore, MD 21202) V.1- 1905-
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
PCBRD2 Progress in Clinical and Biological Research. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1975-
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-
YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1959-

Used in manufacture of CHROMIC ACID and pigments, leather tanning, and corrosion control

NIOSH PROFILE (INORGANIC CHROMIUM COMPOUNDS), SRC, 2/82

FDA-over the counter drug

RTECS Compound Description:
   Tumorigen
   Mutagen
   Reproductive Effector
   Human Data

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