RTECS:HR7780000 The Registry of Toxic Effects of Chemical Substances

The Registry of Toxic Effects of Chemical Substances

Dibutylamine

RTECS #: HR7780000

CAS #: 111-92-2

UPDATE: September 2000 MW: 129.28 MF: C₈H₁₉N

NOTE:

TOXICITY DATA HAVE NOT BEEN EVALUATED. OMISSION OF A SUBSTANCE OR NOTATION DOES NOT IMPLY ANY RELIEF FROM REGULATORY RESPONSIBILITY.

TABLE OF CONTENTS:

SYNONYMS:

SKIN AND EYE IRRITATION DATA:

MUTATION DATA:

ACUTE TOXICITY DATA:

REVIEWS:

NIOSH DOCUMENTATION AND SURVEILLANCE:

STATUS IN FEDERAL AGENCIES:

REFERENCES:

SYNONYMS:

Dibutilamina (Romanian)

1 - Butanamine, N - butyl -

N - Butyl - 1 - butanamine

n - Dibutylamine

SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
skin
rabbit 500 mg open irritation test moderate UCDS 3/25/1970

MUTATION DATA AND REFERENCES:
SYSTEM TEST ROUTE/
ORGANISM/
TISSUE DOSE REFERENCE
cytogenetic analysis hamster fibroblast 200 mg/L/48 hour MUREAV 48,337,1977
DNA repair Bacillus subtilis 5 gm/L MUREAV 42,19,1977

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

TUMORIGENIC DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE**
inhalation
rat lowest published lethal concentration: 500 ppm/4 hour N/R AMIHBC 10,61,1954
intraperitoneal
mouse lethal dose (50 percent kill): 200 mg/kg N/R USXXAM #3816470
intraperitoneal
rat lethal dose (50 percent kill): 110 mg/kg N/R TSCAT* OTS0515594
oral
guinea pig lethal dose (50 percent kill): 230 mg/kg N/R GISAAA 40(11),21,1975
oral
mouse lethal dose (50 percent kill): 290 mg/kg N/R GISAAA 40(11),21,1975
oral
rat lethal dose (50 percent kill): 189 mg/kg N/R RCBUAU 36,667,1985
subcutaneous
rat lethal dose (50 percent kill): 494 mg/kg N/R TSCAT* OTS0515594
skin
rabbit lethal dose (50 percent kill): 770 mg/kg N/R NTIS OTS0535430

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

REVIEWS:
ORGANIZATION STANDARD
REFERENCE

TOXICOLOGY REVIEW
CHREAY 9,389,1931

STANDARDS AND REGULATIONS:
ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 84285;
Number of Industries 8;
Total Number of Facilities 200;
Number of Occupations 6;
Total Number of Employees Exposed 977
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 84285;
Number of Industries 12;
Total Number of Facilities 711;
Number of Occupations 17;
Total Number of Employees Exposed 15,196;
Total Number of Female Employees Exposed 3,349

STATUS IN FEDERAL AGENCIES:
ORGANIZATION
REFERENCE

EPA GENETOX PROGRAM 1988, Positive: In vitro SCE-nonhuman
EPA GENETOX PROGRAM 1988, Positive/dose response: In vitro cytogenetics-nonhuman
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as an industrial chemical
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001

REFERENCES:
CODEN
REFERENCE

AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine. (Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
CHREAY Chemical Reviews. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1924-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NTIS National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
RCBUAU Revista de Chimie (Bucharest). (Rompresfilatelia, POB 12-201, Bucharest, Romania) V.1- 1950-
TSCAT* Office of Toxic Substances Report. (U.S. Environmental Protection Agency, Office of Toxic Substances, 401 M St., SW, Washington, DC 20460)
UCDS Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817)
USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231)

Used as an industrial chemical

NIOSH PROFILE (AMINES, SECONDARY ALIPHATIC), SRI, 2/77

RTECS Compound Description:
   Drug
   Mutagen
   Primary Irritant

Click Here for Additional Information about RTECS**

SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
skin rabbit	500 mg open irritation test	moderate	UCDS** 3/25/1970

SYNONYMS:
Dibutilamina (Romanian) 1 - Butanamine, N - butyl -	N - Butyl - 1 - butanamine n - Dibutylamine

MUTATION DATA AND REFERENCES:
SYSTEM TEST	ROUTE/ ORGANISM/ TISSUE	DOSE	REFERENCE
cytogenetic analysis	hamster fibroblast	200 mg/L/48 hour	MUREAV 48,337,1977
DNA repair	Bacillus subtilis	5 gm/L	MUREAV 42,19,1977

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

TUMORIGENIC DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
inhalation rat	lowest published lethal concentration: 500 ppm/4 hour	N/R	AMIHBC 10,61,1954
intraperitoneal mouse	lethal dose (50 percent kill): 200 mg/kg	N/R	USXXAM #3816470
intraperitoneal rat	lethal dose (50 percent kill): 110 mg/kg	N/R	TSCAT* OTS0515594
oral guinea pig	lethal dose (50 percent kill): 230 mg/kg	N/R	GISAAA 40(11),21,1975
oral mouse	lethal dose (50 percent kill): 290 mg/kg	N/R	GISAAA 40(11),21,1975
oral rat	lethal dose (50 percent kill): 189 mg/kg	N/R	RCBUAU 36,667,1985
subcutaneous rat	lethal dose (50 percent kill): 494 mg/kg	N/R	TSCAT* OTS0515594
skin rabbit	lethal dose (50 percent kill): 770 mg/kg	N/R	NTIS** OTS0535430

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

REVIEWS:
ORGANIZATION	STANDARD	REFERENCE
TOXICOLOGY REVIEW		CHREAY 9,389,1931

STANDARDS AND REGULATIONS:
ORGANIZATION	STANDARD	REFERENCE
N/R	N/R	N/R

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION	STANDARD or SURVEY	REFERENCE
National Occupational Hazard Survey 1974	National Occupational Hazard Survey 1974: Hazard Code: 84285; Number of Industries 8; Total Number of Facilities 200; Number of Occupations 6; Total Number of Employees Exposed 977
National Occupational Exposure Survey 1983	National Occupational Exposure Survey 1983: Hazard Code: 84285; Number of Industries 12; Total Number of Facilities 711; Number of Occupations 17; Total Number of Employees Exposed 15,196; Total Number of Female Employees Exposed 3,349

STATUS IN FEDERAL AGENCIES:
ORGANIZATION	REFERENCE
EPA GENETOX PROGRAM 1988, Positive: In vitro SCE-nonhuman
EPA GENETOX PROGRAM 1988, Positive/dose response: In vitro cytogenetics-nonhuman
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as an industrial chemical
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001

REFERENCES:
CODEN	REFERENCE
AMIHBC	AMA Archives of Industrial Hygiene and Occupational Medicine. (Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
CHREAY	Chemical Reviews. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1924-
GISAAA	Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
MUREAV	Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NTIS**	National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
RCBUAU	Revista de Chimie (Bucharest). (Rompresfilatelia, POB 12-201, Bucharest, Romania) V.1- 1950-
TSCAT*	Office of Toxic Substances Report. (U.S. Environmental Protection Agency, Office of Toxic Substances, 401 M St., SW, Washington, DC 20460)
UCDS**	Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817)
USXXAM	United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231)