The Registry of Toxic Effects of Chemical Substances

Diborane (6)

RTECS #: HQ9275000

CAS #: 19287-45-7

UPDATE: November 2004 MW: 27.68 MF: B2H6


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. Boroethane
  2. Boron hydride
  3. Diborane
  1. Diborane (ACGIH:OSHA)
  2. Diboron hexahydride


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
mutation in microorganisms Salmonella typhimurium 2,000 ppm (+/-enzymatic activation step) MUREAV 307,335,1994
mutation in microorganisms Salmonella typhimurium 5,000 ppm (-enzymatic activation step) MUREAV 307,335,1994


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
dog 		lowest published lethal concentration: 125 ppm/2 hour Brain and Coverings: Changes in surface EEG

Lung, Thorax, or Respiration: Acute pulmonary edema

Blood: Hemorrhage 		AMIHAB 13,346,1956
inhalation
hamster 		lowest published lethal concentration: 50 ppm/8 hour Lung, Thorax, or Respiration: Acute pulmonary edema AMIHAB 21,519,1960
inhalation
mouse 		lethal concentration (50 percent kill): 29 ppm/4 hour Olfaction: Other olfaction effects

Lung, Thorax, or Respiration: Acute pulmonary edema

Lung, Thorax, or Respiration: Dyspnea 		TXAPA9 4,215,1962
inhalation
rat 		lethal concentration (50 percent kill): 40 ppm/4 hour N/R 14KTAK -,693,1964
inhalation
rat 		lethal concentration (50 percent kill): 60 mg/m3/4 hour N/R VCVN1* -,199,1988


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mouse 		lowest published toxic concentration: 5 ppm/6 hour/4 week- intermittent Lung, Thorax, or Respiration: Changes in lung weight

Blood: Changes in erythrocyte (RBC) count

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases 		ARTODN 69,397,1995
inhalation
rat 		lowest published toxic concentration: 100 ppb/6 hour/8 week- intermittent Lung, Thorax, or Respiration: Other changes

Blood: Pigmented or nucleated red blood cells

Nutritional and Gross Metabolic: Changes in: Na 		TXAPA9 138,1977,1996


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.1 ppm DTLVS* TLV/BEI,2003
TOXICOLOGY REVIEW
CTOXAO 6,497,1973


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 0.1 ppm (0.1 mg/m3) DTLVS* 3,72,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 0.1 ppm (0.1 mg/m3) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 0.1 ppm (0.1 mg/m3) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 0.1 ppm (0.1 mg/m3) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 0.1 ppm (0.1 mg/m3) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.1 ppm (0.1 mg/m3), JAN1993
Occupational Exposure Limit - AUSTRIA MAK 0.1 ppm (0.1 mg/m3), JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 0.1 ppm (0.11 mg/m3), JAN1993
Occupational Exposure Limit - FINLAND time-weighted average 0.1 ppm (0.1 mg/m3), short term exposure limit 0.3 ppm (0.3 mg/m3), JAN1999
Occupational Exposure Limit - FRANCE VME 0.1 ppm (0.1 mg/m3), JAN1999
Occupational Exposure Limit - GERMANY MAK 0.1 ppm (0.1 mg/m3), JAN1999
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 0.01 ppm (0.012 mg/m3), JAN1999
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 0.1 mg/m3, 2003
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 0.1 ppm (0.1 mg/m3), JAN1993
Occupational Exposure Limit - RUSSIA short term exposure limit 0.1 mg/m3, JAN1993
Occupational Exposure Limit - SWITZERLAND MAK- week 0.1 ppm (0.1 mg/m3), KZG- week 0.2 ppm, JAN1999
Occupational Exposure Limit - TURKEY time-weighted average 0.1 ppm (0.1 mg/m3), JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 0.1 ppm (0.12 mg/m3), SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 0.1 ppm
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 0.1 ppm


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO DIBORANE-air 10 hour time-weighted average 0.1 ppm NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 23650;
Number of Industries 2;
Total Number of Facilities 24;
Number of Occupations 3;
Total Number of Employees Exposed 409
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 23650;
Number of Industries 4;
Total Number of Facilities 24;
Number of Occupations 12;
Total Number of Employees Exposed 4,616;
Total Number of Female Employees Exposed 1,271


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as the source of boron in the semiconductor industry
On EPA IRIS database
NIOSH Analytical Method, 1994: Diborane, 6006


REFERENCES:

CODEN
REFERENCE
14KTAK "Boron, Metallo-Boron Compounds and Boranes," Adams, R.M., ed., New York, John Wiley & Sons, Inc., 1964
AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21, 1955-60. For publisher information, see AEHLAU.
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CTOXAO Clinical Toxicology. (New York, NY) V.1-18, 1968-81. For publisher information, see JTCTDW.
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
VCVN1* "Vrednie chemichescie veshestva. Neorganicheskie soedinenia elementov I-IV groopp" (Hazardous substances. Inornanic substances containing I-IV group elements), Filov V.A., Chimia, 1988.

Used as the source of boron in the semiconductor industry

NIOSH PROFILE (BORON and ITS COMPOUNDS), SRC, 10/77

RTECS Compound Description:
   Mutagen

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