The Registry of Toxic Effects of Chemical Substances

Decyl alcohol

RTECS #: HE4375000

CAS #: 112-30-1

UPDATE: August 2003 MW: 158.32 MF: C10H22O


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. Agent 504
  2. Alcohol C - 10
  3. Antak
  4. Decanol
  5. n - Decanol
  6. 1 - Decanol
  7. C 10 alcohol
  8. Capric alcohol
  9. Caprinic alcohol
  10. Lorol 22
  1. Sipol L10
  2. n - Decyl alcohol
  3. Dytol S - 91
  4. Epal 10
  5. Nonylcarbinol
  6. Primary decyl alcohol
  7. Royaltac
  8. Royaltac - 85
  9. Royaltac M - 2
  10. T 148


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		83 mg severe AIHAAP 34,493,1973
eye
rabbit 		500 mg/24 hour mild 85JCAE -,202,1986
skin
human 		75 mg/3 day- intermittent severe 85DKA8 -,127,1977
skin
rabbit 		2,600 mg/24 hour moderate AIHAAP 34,493,1973
skin
rabbit 		20 mg/24 hour moderate 85JCAE -,202,1986


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 35,295 mg/kg (1-15 day pregnant) Reproductive: Effects on fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated)

Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) 		ONGZAC 22(1),71,1991
oral
rat 		lowest published toxic dose: 35,295 mg/kg (1-15 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on newborn: Biochemical and metabolic 		ONGZAC 22(1),71,1991


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
skin
mouse 		lowest published toxic dose: 12 gm/kg/25 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Skin and Appendages: Tumors

Tumorigenic: Tumors at site of application 		TXAPA9 9,70,1966


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mammal (species unspecified) 		lethal concentration (50 percent kill): 3 gm/m3 N/R GISAAA 51(5),61,1986
inhalation
mouse 		lethal concentration (50 percent kill): 4 gm/m3/2 hour N/R 85GMAT -,42,1982
intraperitoneal
mouse 		lethal dose (50 percent kill): 800 mg/kg N/R 38MKAJ 2C,4631,1982
intraperitoneal
rat 		lethal dose (50 percent kill): 800 mg/kg N/R 38MKAJ 2C,4631,1982
oral
mouse 		lethal dose (50 percent kill): 6,500 mg/kg N/R FMCHA2 -,C267,1991
oral
mouse 		lowest published lethal dose: 25,000 mg/kg N/R VCVGK* -,118,1984
oral
rat 		lethal dose (50 percent kill): 4,720 mg/kg Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea 		AIHAAP 34,493,1973
skin
rabbit 		lethal dose (50 percent kill): 3,560 mg/kg N/R FCTXAV 11,95,1973


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 180 mg/m3/4 hour/137 day- intermittent Brain and Coverings: Other degenerative changes

Liver: Multiple effects

Kidney, Ureter, and Bladder: Other changes 		VCVGK* -,118,1994
inhalation
rat 		lowest published toxic concentration: 58 mg/m3/26 week- intermittent Eye: Other eye effects VCVGK* -,118,1994
inhalation
rabbit 		lowest published toxic concentration: 200 mg/m3/2 hour/30 day- intermittent Eye: Conjunctiva irritation

Eye: Other eye effects

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		NTIS** PB234-882
inhalation
rabbit 		lowest published toxic concentration: 200 mg/m3/2 hour/30 day- intermittent Eye: Optic nerve neuropathy

Eye: Corneal damage

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		VCVGK* -,118,1994


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Supported RBREV* -,291,1998
Occupational Exposure Limit - RUSSIA short term exposure limit 10 mg/m3, JAN1993


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 83553;
Number of Industries 11;
Total Number of Facilities 219;
Number of Occupations 26;
Total Number of Employees Exposed 5,355
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 83553;
Number of Industries 116;
Total Number of Facilities 6,909;
Number of Occupations 84;
Total Number of Employees Exposed 241,397;
Total Number of Female Employees Exposed 62,584


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as tobacco sucker control agent, DECYL CHLORIDE intermediate, defoamer, food additive
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-9257
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
38MKAJ "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton, G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82. Vol. 3 originally pub. in 1979; pub. as 2nd rev. ed. in 1985.
85DKA8 "Cutaneous Toxicity, Proceedings of the 3rd Conference, 1976," Drill, V.A., and P. Lazar, eds., New York, Academic Press, Inc. 1977
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958-
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7.
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
FMCHA2 Farm Chemicals Handbook. (Meister Pub., 37841 Euclid Ave., Willoughy, OH 44094)
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
ONGZAC Ontogenez (Moscow). For English translation, see SJDBA9. (V/O Mezhdunarodnaya Kniga, 113095, Moscow, USSR) V.1- 1970-
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.

Used as tobacco sucker control agent, DECYL CHLORIDE intermediate, defoamer, food additive

NIOSH PROFILE (ALCOHOLS), SRI, 2/77

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Reproductive Effector
   Natural Product
   Primary Irritant

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