The Registry of Toxic Effects of Chemical Substances

p - Cymene

RTECS #: GZ5950000

CAS #: 99-87-6

UPDATE: February 2004 MW: 134.24 MF: C10H14


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. ACUTE TOXICITY DATA:
  4. STANDARDS AND REGULATIONS:
  5. NIOSH DOCUMENTATION AND SURVEILLANCE:
  6. STATUS IN FEDERAL AGENCIES:
  7. REFERENCES:

SYNONYMS:

  1. Benzene, 1 - isopropyl - 4 - methyl -
  2. Camphogen
  3. Cumene, p - methyl -
  4. Cymene
  5. p - Isopropylmethylbenzene
  6. 4 - Isopropyl - 1 - methylbenzene
  7. p - Isopropyltoluene
  1. Cymol
  2. Dolcymene
  3. p - Methylisopropyl benzene
  4. 1 - Methyl - 4 - isopropylbenzene
  5. Paracymene
  6. Paracymol


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
skin
rabbit 		500 mg/24 hour moderate FCTXAV 12,401,1974


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mouse 		lethal concentration (50 percent kill): 19,500 mg/m3 N/R VCVGH* -,180,1990
intraperitoneal
dog 		lowest published toxic dose: 2 gm/kg Gastrointestinal: Hypermotility, diarrhea VCVGH* -,180,1990
intraperitoneal
guinea pig 		lowest published lethal dose: 2.162 mg/kg N/R VCVGH* -,180,1990
intraperitoneal
mouse 		lethal dose (50 percent kill): 1,125 mg/kg N/R VCVGH* -,180,1990
oral
human 		lowest published toxic dose: 3 gm/kg Gastrointestinal: Nausea or vomiting VCVGH* -,181,1990
oral
mouse 		lethal dose (50 percent kill): 1,695 mg/kg N/R VCVGH* -,180,1990
oral
rat 		lethal dose (50 percent kill): 4,750 mg/kg Eye: Chromodacryorrhea

Behavioral: Somnolence (general depressed activity)

Gastrointestinal: Hypermotility, diarrhea 		FCTXAV 2,327,1964
oral
rat 		lethal dose (50 percent kill): 3,669 mg/kg N/R VCVGH* -,180,1990
oral
rat 		lethal dose (90 percent kill): 5 mL/kg N/R VCVGH* -,180,1990


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - DENMARK time-weighted average 25 ppm (135 mg/m3), JAN1999
Occupational Exposure Limit - RUSSIA short term exposure limit 10 mg/m3, Skin, JAN1993
Occupational Exposure Limit - SWEDEN NGV 25 ppm (140 mg/m3), KTV 35 ppm (190 mg/m3), JAN1999


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X8309;
Number of Industries 96;
Total Number of Facilities 8,820;
Number of Occupations 81;
Total Number of Employees Exposed 176,382;
Total Number of Female Employees Exposed 39,063


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7.
VCVGH* "Vrednie chemichescie veshestva, galogenproisvodnie uglevodorodov". (Hazardous substances: Galogenated hydrocarbons) Bandman A.L. et al., Chimia, 1990.

RTECS Compound Description:
   Natural Product
   Primary Irritant

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