The Registry of Toxic Effects of Chemical Substances

Cyclopropanecarboxylic acid, 2,2 - dimethyl - 3 - (2 - methyl - 1 - propenyl) - , (1,3,4,5,6,7 - hexahydro - 1, 3 - dioxo - 2H - isoindol - 2 - yl) methyl ester

RTECS #: GZ1730000

CAS #: 7696-12-0

UPDATE: August 2003 MW: 331.45 MF: C19H25NO4


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. ACUTE TOXICITY DATA:
  5. STANDARDS AND REGULATIONS:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. REFERENCES:

SYNONYMS:

  1. (+ - ) - cis/trans - Phthalthrin
  2. (1 - Cyclohexane - 1,2 - dicarboximido) methyl chrysanthemumate
  3. 2,3,4,5 - Tetrahydrophthalimidomethylchrysanthemate
  4. 3,4,5,6 - Tetrahydro - phthalimidomethylester der dl - cis - trans - chrysanthemumsaeure (German)
  5. 3,4,5,6 - Tetrahydrophthalimidomethyl cis and trans dl chrysanthemummonocarboxylic acid
  6. Bioneopynamin
  7. ENT 27339
  8. FMC - 9260
  9. Insectol
  10. Multicide
  11. N - (3,4,5,6 - Tetrahydrophthalimido) - methyl dl - cis - trans - chrysanthemate
  12. NIA - 9260
  13. NSC 190939
  1. Neo - pynamin
  2. Neopinamin
  3. Neopynamin forte
  4. Niagara nia - 9260
  5. Phthalthrin
  6. SP 1103 forte
  7. SP - 1103
  8. Sumitomo SP - 1103
  9. Tetralate
  10. Tetramethrin
  11. Tetramethrine (French)
  12. d - Phthalthrin
  13. d - Tetramethrin


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		100 mg/1 hour mild OYYAA2 24,179,1982


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
unscheduled DNA synthesis human other cell types 50 mg/L ZYDXDM 14,1,1985
mutation in microorganisms Salmonella typhimurium 50 mg/L (+enzymatic activation step) ZYDXDM 14,1,1985


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mouse 		lethal concentration (50 percent kill): >2 gm/m3 N/R YKYUA6 36,533,1985
inhalation
rat 		lethal concentration (50 percent kill): >2,500 mg/m3/3 hour N/R 85JFAN A388,1983
intraperitoneal
mouse 		lethal dose (50 percent kill): 527 mg/kg Behavioral: Tremor

Behavioral: Ataxia

Lung, Thorax, or Respiration: Dyspnea 		OYYAA2 24,179,1982
intraperitoneal
rat 		lethal dose (50 percent kill): 548 mg/kg Behavioral: Tremor

Behavioral: Ataxia

Lung, Thorax, or Respiration: Dyspnea 		OYYAA2 24,179,1982
intravenous
rat 		lethal dose (50 percent kill): 3,500 µg/kg N/R ABCHA6 32,628,1968
oral
chicken 		lethal dose (50 percent kill): 5 gm/kg N/R 28ZEAL 5,220,1976
oral
duck 		lethal dose (50 percent kill): >1 gm/kg N/R PEMNDP 9,807,1991
oral
mouse 		lethal dose (50 percent kill): 1 gm/kg N/R ABCHA6 28,914,1965
oral
quail 		lethal dose (50 percent kill): >1 gm/kg N/R PEMNDP 9,807,1991
oral
rat 		lethal dose (50 percent kill): 4,640 mg/kg N/R YKYUA6 35,1315,1984
subcutaneous
mouse 		lethal dose (50 percent kill): 1,950 mg/kg Behavioral: Tremor

Behavioral: Ataxia

Lung, Thorax, or Respiration: Dyspnea 		OYYAA2 24,179,1982
subcutaneous
rat 		lethal dose (50 percent kill): 5,700 mg/kg Behavioral: Somnolence (general depressed activity)

Gastrointestinal: Hypermotility, diarrhea

Kidney, Ureter, and Bladder: Urine volume increased 		OSDIAF 16,509,1967
skin
guinea pig 		lethal dose (50 percent kill): >20 gm/kg Behavioral: Somnolence (general depressed activity)

Skin and Appendages: Other: Hair 		OSDIAF 16,509,1967
skin
mouse 		lethal dose (50 percent kill): >15 gm/kg N/R SPEADM 78-1,6,1978
skin
rat 		lethal dose (50 percent kill): >2,500 mg/kg Behavioral: Tremor

Behavioral: Excitement

Kidney, Ureter, and Bladder: Urine volume increased 		GISAAA 49(4),90,1984


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Supported RBREV* -,212,1998


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X2712;
Number of Industries 10;
Total Number of Facilities 633;
Number of Occupations 13;
Total Number of Employees Exposed 9,244;
Total Number of Female Employees Exposed 1,759


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
N/R


REFERENCES:

CODEN
REFERENCE
28ZEAL "Pesticide Index," Frear, E.H., ed., State College, PA, College Science Pub., 1969
85JFAN "Agrochemicals Handbook," with updates, Hartley, D., and H. Kidd, eds., Nottingham, Royal Soc. of Chemistry, 1983-86
ABCHA6 Agricultural and Biological Chemistry. (Maruzen Co. Ltd., POB 5050, Tokyo International, Tokyo 100-31, Japan) V.25- 1961-
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
OSDIAF Osaka Shiritsu Daigaku Igaku Zasshi. Journal of the Osaka City Medical Center. (Osaka, Japan) V.4-23, 1955-74. For publisher information, see OIGZDE.
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967-
PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968-
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
SPEADM Special Publication of the Entomological Society of America. (4603 Calvert Rd., College Park, MD 20740)
YKYUA6 Yakkyoku. Pharmacy. (Nanzando, 4-1-11, Yushima, Bunkyo-ku, Tokyo, Japan) V.1- 1950-
ZYDXDM Zhejiang Yike Daxue Xuebao. Journal of Zhejiang Medical University. (Zhejiang Yike Daxue, Yan'an Lu, Hanzhou, Zhejiang, Peop. Rep. China) V.1- 1972(?)-

Used as an insecticide

RTECS Compound Description:
   Agricultural Chemical
   Mutagen
   Primary Irritant

ALT CAS #: 28643-67-6
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