The Registry of Toxic Effects of Chemical Substances

Cyclopropanecarboxylic acid, 2,2 - dimethyl - 3 - (2 - methylpropenyl) - , (+) - (E) - , ester with (+) - 2 - allyl - 4 - hydroxy - 3 - methyl - 2 - cyclopenten - 1 - one

RTECS #: GZ1472000

CAS #: 28434-00-6

UPDATE: February 2004 MW: 302.45 MF: C19H26O3


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. REPRODUCTIVE EFFECTS DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. STANDARDS AND REGULATIONS:
  6. REFERENCES:

SYNONYMS:

  1. (+) - Allethronyl (+) - trans - chrysanthemumate
  2. (+) - trans - Allethrin
  3. AI 3 - 29024
  4. Esbioallethrin
  5. Esbiol
  6. Esbiol concentrate 90%
  7. Esbiothrin
  8. Esdepallethrine
  1. RU 16121
  2. S - Bioallethrin
  3. S - bioallethrin
  4. S - trans - Bioallethrin
  5. Wasp Killer II
  6. d - Allethrolone chrysanthemumate
  7. d - T - Allethrin
  8. trans - (+) - Allethrin


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
unreported route
rabbit 		lowest published toxic dose: 2,800 mg/kg (6-19 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system FEREAC 64,55914,1999


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mouse 		lethal concentration (50 percent kill): 2,720 mg/m3/3 hour Behavioral: Excitement

Behavioral: Ataxia

Kidney, Ureter, and Bladder: Other changes 		EVHPAZ 14,15,1976
inhalation
rat 		lethal concentration (50 percent kill): 1,600 mg/m3/3 hour Behavioral: Excitement

Behavioral: Ataxia

Kidney, Ureter, and Bladder: Other changes 		EVHPAZ 14,15,1976
inhalation
rat 		lethal concentration (50 percent kill): 1.26 gm/m3 N/R FEREAC 64,55914,1999
oral
chicken 		lethal dose (50 percent kill): >5 gm/kg N/R PEMNDP 9,78,1991
oral
mouse 		lethal dose (50 percent kill): 250 mg/kg Behavioral: Tremor

Behavioral: Excitement

Behavioral: Ataxia 		EVHPAZ 14,15,1976
oral
rat 		lethal dose (50 percent kill): 430 mg/kg Eye: Chromodacryorrhea

Behavioral: Excitement

Behavioral: Ataxia 		EVHPAZ 14,15,1976
oral
rat 		lethal dose (50 percent kill): 378 mg/kg N/R FEREAC 64,55914,1999
subcutaneous
frog 		lethal dose (50 percent kill): 1,700 µg/kg Behavioral: Tremor

Behavioral: Excitement

Behavioral: Ataxia 		PCBPBS 20,217,1983
subcutaneous
mouse 		lethal dose (50 percent kill): 2,600 mg/kg N/R YKYUA6 28,1451,1977
skin
rat 		lethal dose (50 percent kill): 25 gm/kg N/R YKYUA6 35,1315,1984
skin
rabbit 		lethal dose (50 percent kill): 1,545 mg/kg N/R PEMNDP 9,78,1991


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 25 mg/m3/28 day- intermittent Behavioral: Tremor

Behavioral: Ataxia

Behavioral: Aggression 		FEREAC 64,55914,1999
oral
dog 		lowest published toxic dose: 506 mg/kg/90 day- continuous Behavioral: Tremor

Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		FEREAC 64,55914,1999
oral
rat 		lowest published toxic dose: 9 mg/kg/90 day- continuous Liver: Changes in liver weight

Endocrine: Changes in thyroid weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		FEREAC 64,55914,1999


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Supported RBREV* -,84,1998


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
N/R N/R N/R


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
N/R


REFERENCES:

CODEN
REFERENCE
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972-
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
PCBPBS Pesticide Biochemistry and Physiology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1971-
PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968-
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
YKYUA6 Yakkyoku. Pharmacy. (Nanzando, 4-1-11, Yushima, Bunkyo-ku, Tokyo, Japan) V.1- 1950-

Used mainly in sprays and aerosols against insects in industrial situations

RTECS Compound Description:
   Agricultural Chemical
   Reproductive Effector

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