UPDATE: May 2005 | MW: 416.32 | MF: C22H19Cl2NO3 |
SYNONYMS:
|
|
|
SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
|
| EFFECT
REFERENCE
|
N/R |
N/R
|
N/R
|
N/R
|
|
MUTATION DATA AND REFERENCES:
SYSTEM TEST
|
ROUTE/ | ORGANISM/ TISSUE
DOSE
|
REFERENCE
|
cytogenetic analysis
|
subcutaneous | mouse
50 mg/kg
|
TOLED5 41,223,1988
|
cytogenetic analysis
|
oral | mouse
50 mg/kg
|
TOLED5 41,223,1988
|
cytogenetic analysis
|
unreported route | mouse
10 mg/kg
|
TGANAK 18,455,1984
|
cytogenetic analysis
|
intraperitoneal | mouse
50 mg/kg
|
TOLED5 41,223,1988
|
DNA inhibition
|
human
lymphocyte
|
67 µmol/L
|
DCTODJ 10,291,1987
|
DNA inhibition
|
mouse
leukocyte
|
13 mmol/L
|
DCTODJ 10,291,1987
|
mutation in microorganisms
|
Saccharomyes cerevisiae
|
500 ppm (-enzymatic activation step)
|
MUREAV 280,161,1992
|
micronucleus test
|
hamster
lung
|
1 mg/L
|
CYGEDX 22(4),36,1988
|
micronucleus test
|
human
lymphocyte
|
200 mg/L
|
MUREAV 341,169,1995
|
micronucleus test
|
intraperitoneal | mouse
60 mg/kg/24 hour- continuous
|
TOLED5 41,223,1988
|
micronucleus test
|
oral | mouse
756 mg/kg/7 day- continuous
|
MUREAV 155,135,1985
|
micronucleus test
|
skin | mouse
2,520 mg/kg/7 day- continuous
|
MUREAV 155,135,1985
|
sister chromatid exchange
|
intraperitoneal | mouse
5 mg/kg
|
MOCAT* 18,53,2003
|
sex chromosome loss and nondisjunction
|
oral | Drosophila melanogaster
25 ppm
|
MUTAEX 1,343,1986
|
sex chromosome loss and nondisjunction
|
parenteral | Drosophila melanogaster
10 ppm
|
MUTAEX 1,343,1986
|
sperm morphology
|
intraperitoneal | mouse
30 mg/kg/4 day- continuous
|
TOLED5 41,223,1988
|
|
REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
|
| EFFECT
REFERENCE
|
intraperitoneal | mouse
lowest published toxic dose: 30 mg/kg (1-4 day male)
|
Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)
|
TOLED5 41,223,1988
|
oral | rat
lowest published toxic dose: 500 mg/kg (7-16 day pregnant)
|
Reproductive: Effects on newborn: Other postnatal measures or effects
|
TXCYAC 125,67,1998
|
oral | rat
lowest published toxic dose: 500 mg/kg (7-16 day pregnant)
|
Reproductive: Specific developmental abnormalities: Blood and lymphatic systems (including spleen and marrow) | Reproductive: Specific developmental abnormalities: Immune and reticuloendothelial system
TXCYAC 120,231,1997
|
oral | rat
lowest published toxic dose: 4.4 gm/kg (12 week male)
|
Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females) | Reproductive: Other effects to embryo or fetus
AECTCV 41,522,2001
|
oral | rat
lowest published toxic dose: 6.4 gm/kg (12 week male)
|
Reproductive: Paternal effects: Testes, epididymis, sperm duct | Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females) Reproductive: Other effects to embryo or fetus
AECTCV 41,522,2001
|
oral | rat
lowest published toxic dose: 6,361 mg/kg (84 day male)
|
Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) | Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
AECTCV 41,522,2001
|
oral | rat
lowest published toxic dose: 25 mg/kg (multigeneration)
|
Reproductive: Other effects on male | Reproductive: Other effects on female
FEREAC 68,42030,2003
|
subcutaneous | rat
lowest published toxic dose: 1.75 mg/kg (16-22 day pregnant)
|
Reproductive: Specific developmental abnormalities: Urogenital system | Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
NRTXDN 16,763,1995
|
subcutaneous | rat
lowest published toxic dose: 0.25 mg/kg (multigenerations)
|
Reproductive: Specific developmental abnormalities: Urogenital system | Reproductive: Effects on newborn: Delayed effects
HBPTO* 1,735,2001
|
unreported route | mammal (species unspecified)
lowest published toxic dose: 27 mg/kg (multigenerations)
|
Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)
|
FEREAC 66,47983,2001
|
unreported route | rat
lowest published toxic dose: 400 mg/kg (6-15 day pregnant)
|
Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
|
GISAAA 49(10),70,1984
|
|
TUMORIGENIC DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
|
| EFFECT
REFERENCE
|
skin | mouse
lowest published toxic dose: 780 mg/kg/52 week- intermittent
|
Tumorigenic: Neoplastic by RTECS criteria | Skin and Appendages: Tumors
CALEDQ 182,1,2002
|
skin | mouse
lowest published toxic dose: 960 mg/kg/32 week- intermittent
|
Tumorigenic: Neoplastic by RTECS criteria | Skin and Appendages: Tumors Tumorigenic: Facilitates action of known carcinogens
CALEDQ 182,33,2002
|
|
ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
|
| EFFECT
REFERENCE
|
inhalation | rat
lethal concentration (50 percent kill): 7,889 mg/m3/4 hour
|
N/R
|
DEVEAA 39(236),3,1985
|
inhalation | rat
lethal concentration (50 percent kill): 2.5 gm/m3
|
N/R
|
FEREAC 66,47981,2001
|
intraperitoneal | mouse
lethal dose (50 percent kill): 25 mg/kg
|
N/R
|
INJPD2 22,42,1990
|
intraperitoneal | mouse
lethal dose (70 percent kill): 35 mg/kg
|
Behavioral: Convulsions or effect on seizure threshold | Behavioral: Muscle weakness Lung, Thorax, or Respiration: Respiratory obstruction
VHTODE 42,303,2000
|
intraperitoneal | rat
lethal dose (50 percent kill): 404 mg/kg
|
Behavioral: Tremor | Behavioral: Convulsions or effect on seizure threshold Behavioral: Excitement
WDZAEK 3,184,1989
|
intraperitoneal | rat
lowest published toxic dose: 300 mg/kg
|
Behavioral: Convulsions or effect on seizure threshold | Behavioral: Ataxia Gastrointestinal: Changes in structure or function of salivary glands
TOLED5 125,107,2001
|
intraperitoneal | rat
lethal dose (50 percent kill): 43 mg/kg
|
N/R
|
VHTODE 42,303,2000
|
intraperitoneal | rat
lowest published toxic dose: 58 mg/kg
|
Brain and Coverings: Changes in surface EEG
|
VHTODE 42,303,2000
|
intravenous | rat
lowest published lethal dose: 6 mg/kg
|
Behavioral: Tremor | Behavioral: Change in motor activity (specific assay) Behavioral: Muscle contraction or spasticity
ARTODN 45,325,1980
|
oral | chicken
lethal dose (50 percent kill): 7 gm/kg
|
Behavioral: Tremor | Behavioral: Irritability Gastrointestinal: Changes in structure or function of salivary glands
JJATDK 7,367,1987
|
oral | guinea pig
lethal dose (50 percent kill): 500 mg/kg
|
N/R
|
DEVEAA 34,3,1980
|
oral | hamster
lethal dose (50 percent kill): 400 mg/kg
|
N/R
|
DEVEAA 34,3,1980
|
oral | mammal (species unspecified)
lethal dose (50 percent kill): 247 mg/kg
|
Behavioral: Ataxia
|
FEREAC 66,47981,2001
|
oral | mouse
lethal dose (50 percent kill): 24,570 µg/kg
|
Behavioral: Somnolence (general depressed activity) | Behavioral: Convulsions or effect on seizure threshold Gastrointestinal: Changes in structure or function of salivary glands
JEBIDP 11,331,1990
|
oral | rat
lethal dose (50 percent kill): 57,500 µg/kg
|
Behavioral: Somnolence (general depressed activity) | Behavioral: Convulsions or effect on seizure threshold Gastrointestinal: Changes in structure or function of salivary glands
JEBIDP 11,331,1990
|
oral | rat
lethal dose (50 percent kill): 86.0 mg/kg
|
N/R
|
FEREAC 66,47981,2001
|
oral | rat
lowest published lethal dose: 55.7 mg/kg
|
Blood: Normocytic anemia | Blood: Luekopenia
FEREAC 66,47981,2001
|
oral | rat
lowest published toxic dose: 129 mg/kg
|
Blood: Microcytosis with or without anemia | Blood: Changes in erythrocyte (RBC) count Blood: Changes in leukocyte (WBC) count
BECTA6 70,839,2003
|
oral | rat
lowest published lethal dose: 643 mg/kg
|
N/R
|
BECTA6 70,839,2003
|
oral | rabbit
lethal dose (50 percent kill): 1,500 mg/kg
|
Behavioral: Somnolence (general depressed activity) | Behavioral: Convulsions or effect on seizure threshold Gastrointestinal: Changes in structure or function of salivary glands
JEBIDP 11,331,1990
|
skin | mammal (species unspecified)
lethal dose (50 percent kill): 2,355 mg/kg
|
N/R
|
GISAAA 56(4),83,1991
|
skin | rat
lethal dose (50 percent kill): >1,600 mg/kg
|
N/R
|
85JFAN A110,1984
|
skin | rabbit
lethal dose (50 percent kill): >2,400 mg/kg
|
N/R
|
PEMNDP 9,208,1991
|
skin | rabbit
lethal dose (50 percent kill): 2,460 mg/kg
|
Eye: Lacrimation | Behavioral: Tremor
FEREAC 66,47981,2001
|
unreported route | domestic bird
lethal dose (50 percent kill): 3 gm/kg
|
N/R
|
DEVEAA 34,3,1980
|
unreported route | chicken
lethal dose (50 percent kill): 2 gm/kg
|
N/R
|
DEVEAA 34,3,1980
|
unreported route | rat
lethal dose (50 percent kill): 400 mg/kg
|
N/R
|
GISAAA 49(10),70,1984
|
unreported route | rat
lowest published toxic dose: 50 mg/kg
|
Behavioral: Somnolence (general depressed activity) | Behavioral: Food intake (animal) Nutritional and Gross Metabolic: Weight loss or decreased weight gain
FEREAC 66,47984,2001
|
unreported route | rat
lowest published toxic dose: 26.3 mg/kg
|
Behavioral: Food intake (animal) | Nutritional and Gross Metabolic: Weight loss or decreased weight gain
FEREAC 66,47985,2001
|
|
OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
|
| EFFECT
REFERENCE
|
inhalation | rat
lowest published toxic concentration: 300 µg/m3/24 hour/13 week- continuous
|
Blood: Other changes | Immunological Including Allergic: Decreased immune response Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases
GISAAA 55(2),20,1990
|
intraperitoneal | mouse
lowest published toxic dose: 130 mg/kg/26 day- intermittent
|
Immunological Including Allergic: Hypersensitivity delayed (multiple organ involvement)
|
HBPTO* 1,777,2001
|
intraperitoneal | rat
lowest published toxic dose: 2,100 mg/kg /7 day- intermittent
|
Liver: Changes in liver weight | Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TOLED5 125,107,2001
|
intraperitoneal | rat
lowest published toxic dose: 900 mg/kg /3 day- intermittent
|
Behavioral: Muscle weakness | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
TOLED5 125,107,2001
|
intraperitoneal | rat
lowest published toxic dose: 1,500 mg/kg/5 day- intermittent
|
Liver: Other changes | Biochemical: Metabolism (intermediary): Lipids including transport
TOLED5 125,107,2001
|
oral | chicken
lowest published toxic dose: 69,993 µg/kg/21 day- intermittent
|
Endocrine: Hypoglycemia | Blood: Change in clotting factors Blood: Other changes
JJATDK 7,367,1987
|
oral | mouse
lowest published toxic dose: 169,680 mg/kg/101 week- continuous
|
Lung, Thorax, or Respiration: Tumors
|
HBPTO* 1,814,2001
|
oral | quail
lowest published toxic dose: 1,157 mg/kg/7 day- continuous
|
Gastrointestinal: Other changes | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation)
BECTA6 31,479,1983
|
oral | rat
lowest published toxic dose: 2,275 mg/kg/13 week- intermittent
|
Immunological Including Allergic: Decrease in cellular immune response | Immunological Including Allergic: Decrease in humoral immune response
ATSUDG 8,305,1985
|
oral | rat
lowest published toxic dose: 1,050 mg/kg/7 day- intermittent
|
Peripheral Nerve and Sensation: Recording from peripheral motor nerve | Behavioral: Muscle weakness Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes
ARTODN 53,297,1983
|
oral | rat
lowest published toxic dose: 1,500 mg/kg/30 day- intermittent
|
Kidney, Ureter, and Bladder: Urine volume increased | Kidney, Ureter, and Bladder: Proteinuria
BCTKAG 21,146,1988
|
oral | rat
lowest published toxic dose: 1,512 mg/kg/28 day- continuous
|
Behavioral: Convulsions or effect on seizure threshold | Behavioral: Change in motor activity (specific assay) Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTIS** OTS0539722
|
oral | rat
lowest published toxic dose: 1.55 gm/kg/4 week- intermittent
|
Immunological Including Allergic: Decrease in cellular immune response | Immunological Including Allergic: Decrease in humoral immune response
TXCYAC 172,59,2002
|
oral | rat
lowest published toxic dose: 750 mg/kg/60 day- intermittent
|
Blood: Other changes | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases Biochemical: Metabolism (intermediary): Lipids including transport
TXCYAC 175,91,2002
|
oral | rat
lowest published toxic dose: 1,500 mg/kg/60 day- intermittent
|
Liver: Changes in liver weight | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects Biochemical: Metabolism (intermediary): Lipids including transport
TXCYAC 191,233,2003
|
oral | rat
lowest published toxic dose: 42.98 mg/kg/7 day- intermittent
|
Blood: Microcytosis with or without anemia | Blood: Changes in erythrocyte (RBC) count
BECTA6 70,839,2003
|
oral | rat
lowest published toxic dose: 85.96 mg/kg/14 day- intermittent
|
Blood: Microcytosis with or without anemia | Blood: Changes in erythrocyte (RBC) count Blood: Changes in leukocyte (WBC) count
BECTA6 70,839,2003
|
oral | rabbit
lowest published toxic dose: 6,300 mg/kg/6 week- intermittent
|
Immunological Including Allergic: Decrease in cellular immune response | Immunological Including Allergic: Decrease in humoral immune response
ATSUDG 8,305,1985
|
oral | rabbit
lowest published toxic dose: 1,008 mg/kg/12 week- intermittent
|
Endocrine: Hyperglycemia | Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical: Metabolism (intermediary): Lipids including transport
TXCYAC 189,223,2003
|
skin | domestic animal
lowest published toxic dose: 1,248 mg/kg/30 day- intermittent
|
Immunological Including Allergic: Hypersensitivity delayed (multiple organ involvement)
|
HBPTO* 1,777,2001
|
skin | guinea pig
lowest published toxic dose: 0.59 gm/kg/21 day- intermittent
|
Skin: After topical application: Cutaneous sensitization (experimental)
|
JAPTO* 21,257,2001
|
skin | mouse
lowest published toxic dose: 125 mg/kg/5 day- intermittent
|
Immunological Including Allergic: Increase in humoral response | Tumorigenic: Cells (cultured) transformed
JAPTO* 21,257,2001
|
|
REVIEWS:
ORGANIZATION
|
STANDARD
|
|
REFERENCE
TOXICOLOGY REVIEW
|
|
JTCTDW 38,103,2000
|
TOXICOLOGY REVIEW
|
|
TOLED5 1422072003
|
|
STANDARDS AND REGULATIONS:
ORGANIZATION
|
STANDARD
|
|
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988
|
PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION
|
FEREAC 54,7740,1989
|
|
NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION
|
STANDARD or SURVEY
|
|
REFERENCE
N/R
|
N/R
|
N/R
|
|
STATUS IN FEDERAL AGENCIES:
ORGANIZATION
|
|
REFERENCE
EPA GENETOX PROGRAM 1988, Negative: In vitro UDS-human fibroblast; S cerevisiae-homozygosis
|
Used for control of ticks, flies, lice, mites, scab and mange on livestock
|
EPA TSCA Section 8(d) unpublished health/safety studies
|
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-9157;8EHQ-0892-9069
|
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-9085;8EHQ-0892-9309
|
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-9310
|
On EPA IRIS database
|
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
|
|
REFERENCES:
CODEN
|
|
REFERENCE
85JFAN
|
"Agrochemicals Handbook," with updates, Hartley, D., and H. Kidd, eds., Nottingham, Royal Soc.
of Chemistry, 1983-86
|
AECTCV
|
Archives of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc.,
Service Center, 44 Hartz Way, Secaucus, NJ 070944) V.1- 1973-
|
ARTODN
|
Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep.
Ger.) V.32- 1974-
|
ATSUDG
|
Archives of Toxicology, Supplement. (Springer-Verlag New York, Inc., Service Center, 44 Hartz
Way, Secaucus, NJ 07094) No.1- 1978-
|
BCTKAG
|
Bromatologia i Chemia Toksykologiczna. (Ars Polona, POB 1001, 00-068 Warsaw 1, Poland) V.4-
1971-
|
BECTA6
|
Bulletin of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc.,
Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1966-
|
CALEDQ
|
Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick,
Ireland) V.1- 1975-
|
CYGEDX
|
Cytology and Genetics (English Translation). Translation of TGANAK. (Allerton Press Inc.,
150 Fifth Ave., New York, NY 10011) V.8- 1974-
|
DCTODJ
|
Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1-
1977/78-
|
DEVEAA
|
Defense des Vegetaux. (Federation Nationale des Groupements de Protection des Cultures, 149,
rue de Bercy, 75595 Paris Cedex, 12, France) V.1- 1947-
|
FEREAC
|
Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
V.1- 1936-
|
GISAAA
|
Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga,
113095 Moscow, USSR) V.1- 1936-
|
HBPTO*
|
Handbook of pesticide toxicology. Robert Krieger ed, Academic press, 2001
|
INJPD2
|
Indian Journal of Pharmacology. (Dept. of Pharmacology, Baranas Hindu Univ., Varanasi 221
005, India) V.1- 1968(?)-
|
JAPTO*
|
Journal of Applied Toxicology (John Wiley & Sons, Ltd., Oldlands Way Bognor Regis West Sussex,
PO22 9SA England) V.1- 1981-
|
JEBIDP
|
Journal of Environmental Biology. (Academy of Environmental Biology, India, 657/5, Civil
Lines (South), Muzaffarnagar, 251001, India) V.1- 1980-
|
JJATDK
|
JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd., Baffins Lane, Chichester, W.
Sussex PO19 1UD, UK) V.1- 1981-
|
JTCTDW
|
Journal of Toxicology, Clinical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY
10016) V.19- 1982-
|
MOCAT*
|
Molecular Cancer Therapeutics (Philadelphia, PA : American Association for Cancer Research)
V.1- 2001-
|
MUREAV
|
Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1-
1964-
|
MUTAEX
|
Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ,
UK) V.1- 1986-
|
NRTXDN
|
Neurotoxicology. (Intox Press, Inc., POB 34075, Little Rock, AR 72203) V.1- 1979-
|
NTIS**
|
National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse
for Scientific & Technical Information.
|
PEMNDP
|
Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4
7QG, UK) V.1- 1968-
|
TGANAK
|
Tsitologiya i Genetika. Cytology and Genetics. For English translation, see CYGEDX. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1967-
|
TOLED5
|
Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands)
V.1- 1977-
|
TXCYAC
|
Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-
|
VHTODE
|
Veterinary and Human Toxicology. (American College of Veterinary and Comparative Toxicology,
Publication Office, Comparative Toxicology, Manhattan, KS 66506) V.19- 1977-
|
WDZAEK
|
Weisheng Dulixue Zazhi. Journal of Health Toxicology. (Weisheng Dulixue Zazhi Bianjibu,
Dongdaqiao, Chaoyang Menwai, Beijing, Peop. Rep. China) V.1- 1987
|
|