The Registry of Toxic Effects of Chemical Substances

Cyclopropanecarboxylic acid, 3 - (2 - chloro - 3,3,3 - trifluoro - 1 - propenyl) - 2,2 - dimethyl - ,cyano (3 - phenoxyphenyl) methyl ester, (1 - alpha (S*) ,3 - alpha (Z) ) - (+ - ) -

RTECS #: GZ1227780

CAS #: 91465-08-6

UPDATE: May 2005 MW: 449.88 MF: C23H19ClF3NO3


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. REFERENCES:

SYNONYMS:

  1. Cyhalothrin K
  2. Icon
  3. Karate
  4. Lambda - cyhalothrin
  1. Lambda - cyhalothrin technical
  2. Lambdacyalothrin
  3. PP 321
  4. lambda - Cyhalothrin


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis intraperitoneal
rat 		21.42 mg/kg/13 day MUREAV 539,91,2003
micronucleus test multiple
non-mammalian species 		0.1 mg/L/36 hour MUREAV 534,93,2003
micronucleus test multiple
non-mammalian species 		0.1 mg/L/90 minute MUREAV 534,93,2003
micronucleus test multiple
other fish 		10 ng/L MUREAV 438,155,1999
micronucleus test intraperitoneal
rat 		5.6 mg/kg/13 day MUREAV 539,91,2003


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mammal (species unspecified) 		lowest published toxic dose: 5 mg/kg (multigenerations) Reproductive: Effects on newborn: Weaning or lactation index (e.g., # alive at weaning per # alive at day 4)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) 		FEREAC 63,7293,1998
oral
rat 		lowest published toxic dose: 5 mg/kg (multigeneration) Reproductive: Other effects on male

Reproductive: Other effects on female

Reproductive: Effects on newborn: Other neonatal measures or effects 		FEREAC 68,52354,2003


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mammal (species unspecified) 		lethal concentration (50 percent kill): 60 mg/m3/4 hour N/R PEMNDP 9,203,1991
intravenous
rat 		lethal dose (50 percent kill): 1,951 µg/kg Behavioral: Convulsions or effect on seizure threshold

Behavioral: Ataxia

Gastrointestinal: Changes in structure or function of salivary glands 		PCBPBS 30,79,1988
oral
duck 		lethal dose (50 percent kill): >3,950 mg/kg N/R FMCHA2 -,C175,1991
oral
rat 		lethal dose (50 percent kill): 56 mg/kg N/R FEREAC 63,7293,1998
skin
rat 		lethal dose (50 percent kill): 632 mg/kg N/R PEMNDP 9,203,1991
unreported route
rat 		lethal dose (50 percent kill): 632 mg/kg N/R FEREAC 63,7293,1998


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 18.9 mg/kg/21 day- intermittent Behavioral: Ataxia

Eye: Corneal damage

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		FEREAC 67,60903,2002
inhalation
rat 		lowest published toxic concentration: 3.3 mg/m3/21 day- intermittent Eye: Corneal damage

Behavioral: Ataxia

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		FEREAC 68,52354,2003
oral
dog 		lowest published toxic dose: 182.5 mg/kg/1 year- intermittent Behavioral: Ataxia FEREAC 67,60903,2002
oral
dog 		lowest published toxic dose: 7 mg/kg/2 day- intermittent Behavioral: Ataxia FEREAC 68,52354,2003
oral
rat 		lowest published toxic dose: 1,137.5 mg/kg/13 week- intermittent Behavioral: Food intake (animal)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		FEREAC 67,60903,2002
skin
dog 		lowest published toxic dose: 1,050 mg/kg/21 day- intermittent Behavioral: Ataxia

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		FEREAC 68,52354,2003
skin
rat 		lowest published toxic dose: 1,050 mg/kg/21 day- intermittent Behavioral: Ataxia

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		FEREAC 67,60903,2002


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
TOXICOLOGY REVIEW
TOLED5 127,29,2002


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Active registration RBREV* -,362,1998


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
N/R N/R N/R


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
N/R


REFERENCES:

CODEN
REFERENCE
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
FMCHA2 Farm Chemicals Handbook. (Meister Pub., 37841 Euclid Ave., Willoughy, OH 44094)
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
PCBPBS Pesticide Biochemistry and Physiology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1971-
PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968-
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-

Used as an insecticide

RTECS Compound Description:
   Agricultural Chemical
   Mutagen
   Reproductive Effector

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