The Registry of Toxic Effects of Chemical Substances
Cyclopentanone RTECS #: GY4725000
CAS #: 120-92-3
The Registry of Toxic Effects of Chemical Substances
Cyclopentanone |
| UPDATE: November 2003 | MW: 84.13 | MF: C5H8O |
SYNONYMS:
|
|
| |
SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
|
| EFFECT
REFERENCE
|
eye | rabbit
100 mg
|
severe
|
FCTOD7 20,573,1982
|
eye | rabbit
100 mg/4S rinse
|
severe
|
FCTOD7 20,573,1982
|
skin | rabbit
500 mg/24 hour
|
severe
|
FCTXAV 17,271,1979
|
skin | rabbit
500 mg
|
mild
|
FCTOD7 20,563,1982
|
| |||
MUTATION DATA AND REFERENCES:
SYSTEM TEST
|
ROUTE/ | ORGANISM/ TISSUE
DOSE
|
REFERENCE
|
N/R
|
N/R
|
N/R
|
N/R
|
| |||
REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
|
| EFFECT
REFERENCE
|
N/R |
N/R
|
N/R
|
N/R
|
| |||
TUMORIGENIC DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
|
| EFFECT
REFERENCE
|
N/R |
N/R
|
N/R
|
N/R
|
| |||
ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
|
| EFFECT
REFERENCE
|
inhalation | rat
lethal concentration (50 percent kill): 19,500 mg/m3
|
Lung, Thorax, or Respiration: Dyspnea | Lung, Thorax, or Respiration: Other changes Liver: Other changes
NTIS** OTS0572861
|
intraperitoneal | mouse
lethal dose (50 percent kill): 1,950 mg/kg
|
Behavioral: Somnolence (general depressed activity) | Behavioral: Muscle weakness Behavioral: Coma
COREAF 254,2245,1962
|
oral | mammal (species unspecified)
lethal dose (50 percent kill): 2 gm/kg
|
N/R
|
GTPZAB 32(10),25,1988
|
oral | mouse
lethal dose (50 percent kill): 1,820 mg/kg
|
N/R
|
VCVGK* -,453,1994
|
subcutaneous | frog
lowest published lethal dose: 3 gm/kg
|
Autonomic Nervous System: Other (direct) parasympathomimetic | Behavioral: Change in motor activity (specific assay) Skin and Appendages: Other: Sweating
AEXPBL 50,199,1903
|
subcutaneous | mouse
lowest published lethal dose: 2,600 mg/kg
|
Autonomic Nervous System: Other (direct) parasympathomimetic | Behavioral: Coma Lung, Thorax, or Respiration: Other changes
AEXPBL 50,199,1903
|
| |||
OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
|
| EFFECT
REFERENCE
|
inhalation | mammal (species unspecified)
lowest published toxic concentration: 50 ppm/6 hour/15 week- intermittent
|
Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)
|
VCVGK* -,453,1994
|
| |||
REVIEWS:
ORGANIZATION
|
STANDARD
|
|
REFERENCE
N/R
|
N/R
|
N/R
|
| ||
STANDARDS AND REGULATIONS:
ORGANIZATION
|
STANDARD
|
|
REFERENCE
Occupational Exposure Limit - DENMARK
|
time-weighted average 25 ppm (90 mg/m3), JAN1999
|
| |||
NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION
|
STANDARD or SURVEY
|
|
REFERENCE
N/R
|
N/R
|
N/R
|
| ||
STATUS IN FEDERAL AGENCIES:
ORGANIZATION
|
|
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
|
EPA TSCA Section 8(d) unpublished health/safety studies
|
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
|
| ||||
REFERENCES:
CODEN
|
|
REFERENCE
AEXPBL
|
Archiv fuer Experimentelle Pathologie und Pharmakologie. (Leipzig, Ger. Dem. Rep.) V.1-109,
1873-1925. For publisher information, see NSAPCC.
|
COREAF
|
Comptes Rendus Hebdomadaires des Seances, Academie des Sciences. (Paris, France) V.1-261,
1835-1965. For publisher information, see CRASEV.
|
FCTOD7
|
Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford,
NY 10523) V.20- 1982-
|
FCTXAV
|
Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see
FCTOD7.
|
GTPZAB
|
Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see
MTPEEI
|
NTIS**
|
National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse
for Scientific & Technical Information.
|
VCVGK*
|
"Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia".
(Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia,
1994.
|
| |