The Registry of Toxic Effects of Chemical Substances

Cyclopentane

RTECS #: GY2390000

CAS #: 287-92-3

UPDATE: November 2004 MW: 70.15 MF: C5H10


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. ACUTE TOXICITY DATA:
  3. OTHER MULTIPLE DOSE DATA:
  4. REVIEWS:
  5. STANDARDS AND REGULATIONS:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. Cyclopentane (ACGIH)
  1. Pentamethylene


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mouse 		lethal concentration (50 percent kill): 72 gm/m3 Behavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold 		TOVEFN (4),33,2000
inhalation
mouse 		lowest published lethal concentration: 110,000 mg/m3 Behavioral: General anesthetic VCVGH* -,81,1990
inhalation
rat 		lethal concentration (50 percent kill): 106 gm/m3 Behavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold 		TOVEFN (4),33,2000
oral
mouse 		lethal dose (50 percent kill): 12,800 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold 		TOVEFN (4),33,2000
oral
rat 		lethal dose (50 percent kill): 11,400 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold 		TOVEFN (4),33,2000


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 34,200 mg/kg/30 day- intermittent Kidney, Ureter, and Bladder: Renal function tests depressed

Blood: Other changes 		TOVEFN (4),33,2000


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 600 ppm DTLVS* TLV/BEI,2003
TOXICOLOGY REVIEW
MUREAV 539,77,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - AUSTRALIA time-weighted average 600 ppm (1720 mg/m3), JAN1993
Occupational Exposure Limit - BELGIUM time-weighted average 600 ppm (1720 mg/m3), JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 300 ppm (850 mg/m3), JAN1999
Occupational Exposure Limit - FRANCE VME 600 ppm (1720 mg/m3), JAN1999
Occupational Exposure Limit - NORWAY time-weighted average 300 ppm (850 mg/m3), JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 600 ppm (1720 mg/m3), JAN1999
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 1720 mg/m3, 2003
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 600 ppm
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 600 ppm


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO CYCLOPENTANE-air 10 hour time-weighted average 600 ppm NIOSH* DHHS #95-121,1995
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 82935;
Number of Industries 77;
Total Number of Facilities 8,027;
Number of Occupations 52;
Total Number of Employees Exposed 74,753


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
TOVEFN Toksikologicheskii Vestnik. (18-20 Vadkovskii per. Moscow, 101479, Russia) History Unknown
VCVGH* "Vrednie chemichescie veshestva, galogenproisvodnie uglevodorodov". (Hazardous substances: Galogenated hydrocarbons) Bandman A.L. et al., Chimia, 1990.

NIOSH PROFILE (PETROLEUM REFINING), FIRL, 4/78

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