The Registry of Toxic Effects of Chemical Substances
Cyclohexylamine |
UPDATE: November 2004 | MW: 99.20 | MF: C6H13N |
SYNONYMS:
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SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
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eye | rabbit
50 µg/24 hour
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severe
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85JCAE -,454,1986
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eye | rabbit
100 µL/5 minute
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severe
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NTIS** OTS0540890
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skin | human
125 mg/48 hour
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severe
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AMIHBC 5,311,1952
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skin | rabbit
2 mg/24 hour
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severe
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85JCAE -,454,1986
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skin | rabbit
500 µL
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severe
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NTIS** OTS0540890
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MUTATION DATA AND REFERENCES:
SYSTEM TEST
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ROUTE/ | ORGANISM/ TISSUE
DOSE
|
REFERENCE
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cytogenetic analysis
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unreported route | domestic animal
50 mg/kg
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MUREAV 26,407,1974
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cytogenetic analysis
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hamster
fibroblast
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10 mg/L
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MUREAV 39,1,1976
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cytogenetic analysis
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human
leukocyte
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10 µmol/L/5 hour
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MUREAV 39,1,1976
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cytogenetic analysis
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mammal (species unspecified)
kidney
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50 mg/L/8 hour- continuous
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FCTXAV 8,617,1970
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cytogenetic analysis
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intraperitoneal | rat
5 mg/kg/5 day- continuous
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SCIEAS 165,1139,1969
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dominant lethal test
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intraperitoneal | mouse
500 mg/kg/5 day- intermittent
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MUREAV 14,126,1972
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DNA inhibition
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human
HeLa cell
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100 µg/L
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INHEAO 9,188,1971
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host-mediated assay
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hamster
| leukocyte
450 mg/kg/3 day- continuous
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MUREAV 31,5,1975
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morphological transform
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hamster
embryo
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60 mg/L
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AETODY 1,241,1980
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specific locus test
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intraperitoneal | mouse
200 mg/kg
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PCBRD2 109,339,1982
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REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
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intraperitoneal | mouse
lowest published toxic dose: 61 mg/kg (11 day pregnant)
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Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
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TJADAB 4,141,1971
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intraperitoneal | mouse
lowest published toxic dose: 77 mg/kg (11 day pregnant)
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Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)
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TJADAB 4,141,1971
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intraperitoneal | mouse
lowest published toxic dose: 200 mg/kg (10 day pregnant)
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Reproductive: Effects on fertility: Other measures of fertility
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PCBRD2 109,339,1982
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intraperitoneal | rat
lowest published toxic dose: 300 mg/kg (1 day male)
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Reproductive: Effects on fertility: Other measures of fertility
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FCTXAV 10,29,1972
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intraperitoneal | rat
lowest published toxic dose: 100 mg/kg (1 day male)
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Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)
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FCTXAV 10,29,1972
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oral | dog
lowest published toxic dose: 14 gm/kg (8 week male)
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Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)
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FCTXAV 19,291,1981
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oral | dog
lowest published toxic dose: 15,750 mg/kg (9 week male)
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Reproductive: Paternal effects: Testes, epididymis, sperm duct
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FCTXAV 19,291,1981
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oral | mouse
lowest published toxic dose: 600 mg/kg (6-11 day pregnant)
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Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) | Reproductive: Effects on embryo or fetus: Fetal death
SEIJBO 11,51,1971
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oral | mouse
lowest published toxic dose: 120 mg/kg (6-11 day pregnant)
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Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
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SEIJBO 11,51,1971
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oral | rat
lowest published toxic dose: 5,600 mg/kg (4 week male)
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Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)
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FCTXAV 19,291,1981
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parenteral | mouse
lowest published toxic dose: 250 mg/kg (5 day male)
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Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)
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AMESES 1,33,1970
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unreported route | rat
lowest published toxic dose: 5 mg/kg (1 day male)
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Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)
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AMESES 1,25,1970
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TUMORIGENIC DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
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N/R |
N/R
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N/R
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N/R
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ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
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inhalation | guinea pig
lowest published lethal concentration: 1,200 ppm/7 hour
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Lung, Thorax, or Respiration: Other changes
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IMSUAI 19,317,1950
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inhalation | mouse
lethal concentration (50 percent kill): 1,070 mg/m3
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Behavioral: Excitement | Behavioral: Muscle contraction or spasticity
GTPZAB 7(11),51,1963
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inhalation | rat
lethal concentration (50 percent kill): 7,500 mg/m3
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Behavioral: Excitement | Behavioral: Muscle contraction or spasticity
GTPZAB 7(11),51,1963
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inhalation | rabbit
lowest published lethal concentration: 150 ppm/7 hour
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N/R
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IMSUAI 19,317,1950
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intraperitoneal | mammal (species unspecified)
lethal dose (50 percent kill): 200 mg/kg
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Brain and Coverings: Other degenerative changes | Vascular: Shock Liver: Other changes
AMIHBC 5,311,1952
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intraperitoneal | mouse
lethal dose (50 percent kill): 129 mg/kg
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N/R
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PCJOAU 22,469,1988
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intraperitoneal | rat
lethal dose (50 percent kill): 300 mg/kg
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Eye: Mydriasis (pupilliary dilation) | Behavioral: Ataxia Lung, Thorax, or Respiration: Dyspnea
NYKZAU 65(1),53S,1969
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intravenous | dog
lethal dose (50 percent kill): 200 mg/kg
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Behavioral: Convulsions or effect on seizure threshold
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NYKZAU 65(1),53S,1969
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intravenous | mouse
lethal dose (50 percent kill): 200 mg/kg
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N/R
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IPSTB3 3,93,1976
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oral | mouse
lethal dose (50 percent kill): 224 mg/kg
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N/R
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85GMAT -,41,1982
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oral | rat
lethal dose (50 percent kill): 11 mg/kg
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Behavioral: Food intake (animal) | Lung, Thorax, or Respiration: Pulmonary emboli Gastrointestinal: Other changes
NTIS** OTS0534836
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parenteral | rabbit
lowest published lethal dose: 500 mg/kg
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Behavioral: Convulsions or effect on seizure threshold
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IECHAD 29,1247,1937
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subcutaneous | mouse
lethal dose (50 percent kill): 1,150 mg/kg
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N/R
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VOONAW 4,659,1958
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skin | rabbit
lethal dose (50 percent kill): 320 µL/kg
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N/R
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AIHAAP 30,470,1969
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unreported route | mouse
lethal dose (50 percent kill): 770 mg/kg
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N/R
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TXAPA9 14,654,1969
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OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
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inhalation | rat
lowest published toxic concentration: 700 mg/m3/2 hour/9 week- intermittent
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Cardiac: Changes in heart weight | Kidney, Ureter, and Bladder: Changes in bladder weight Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
GTPZAB 7(11),51,1963
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inhalation | rat
lowest published toxic concentration: 100 mg/m3/4 hour/22 week- intermittent
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Kidney, Ureter, and Bladder: Changes in bladder weight | Blood: Changes in cell count (unspecified) Nutritional and Gross Metabolic: Other changes
GTPZAB 7(11),51,1963
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oral | rat
lowest published toxic dose: 35,700 mg/kg/1 year- continuous
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Liver: Other changes | Kidney, Ureter, and Bladder: Other changes
VOONAW 4,659,1958
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oral | rat
lowest published toxic dose: 1,200 mg/kg/3 day- continuous
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Behavioral: Food intake (animal) | Nutritional and Gross Metabolic: Weight loss or decreased weight gain
EXMPA6 52,155,1990
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oral | rat
lowest published toxic dose: 2,800 mg/kg/1 week- continuous
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Related to Chronic Data: Changes in testicular weight
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EXMPA6 52,155,1990
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oral | rat
lowest published toxic dose: 8,400 mg/kg/3 week- continuous
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Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) | Reproductive: Paternal effects: Testes, epididymis, sperm duct
EXMPA6 52,155,1990
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REVIEWS:
ORGANIZATION
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STANDARD
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REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
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time-weighted average 10 ppm
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DTLVS* TLV/BEI,2003
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American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
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Not Classifiable as a Human Carcinogen
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DTLVS* TLV/BEI,2003
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International Agency for Research on Cancer (IARC) Cancer Review
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Animal Limited Evidence
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IMSUDL 7,178,1987
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International Agency for Research on Cancer (IARC) Cancer Review
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Animal NO EVIDENCE
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IMEMDT 22,55,1980
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International Agency for Research on Cancer (IARC) Cancer Review
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Human Inadequate Evidence
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IMSUDL 22,55,1980
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International Agency for Research on Cancer (IARC) Cancer Review
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Group 3
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IMSUDL 7,178,1987
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TOXICOLOGY REVIEW
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MUREAV 39,1,1976
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STANDARDS AND REGULATIONS:
ORGANIZATION
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STANDARD
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REFERENCE
Occupational Exposure Limit - AUSTRALIA
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time-weighted average 10 ppm (40 mg/m3), JAN1993
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Occupational Exposure Limit - AUSTRIA
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MAK 10 ppm (40 mg/m3), JAN1999
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Occupational Exposure Limit - BELGIUM
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time-weighted average 10 ppm (41 mg/m3), JAN1993
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Occupational Exposure Limit - DENMARK
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time-weighted average 10 ppm (40 mg/m3), Skin, JAN1999
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Occupational Exposure Limit - FINLAND
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short term exposure limit 10 ppm (40 mg/m3), Skin, JAN1999
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Occupational Exposure Limit - FRANCE
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VME 10 ppm (40 mg/m3), Skin, JAN1999
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Occupational Exposure Limit - GERMANY
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MAK 10 ppm (40 mg/m3), JAN1999
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Occupational Exposure Limit - HUNGARY
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time-weighted average 1 mg/m3, short term exposure limit 2 mg/m3, JAN1993
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Occupational Exposure Limit - THE NETHERLANDS
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MAC-TGG 5 mg/m3, Skin, 2003
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Occupational Exposure Limit - POLAND
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time-weighted average 40 mg/m3, short term exposure limit 80 mg/m3, JAN1999
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Occupational Exposure Limit - RUSSIA
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short term exposure limit 1 mg/m3, JAN1993
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Occupational Exposure Limit - SWEDEN
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time-weighted average 5 ppm (20 mg/m3), short term exposure limit 10 ppm (40 mg/m3), JAN1999
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Occupational Exposure Limit - SWITZERLAND
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MAK- week 10 ppm (40 mg/m3), KZG- week 20 ppm (80 mg/m3), Skin, JAN1999
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Occupational Exposure Limit - UNITED KINGDOM
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time-weighted average 10 ppm (41 mg/m3), SEP2000
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Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA
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American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value; | Not Classifiable as a Human Carcinogen
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM
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American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value |
Not Classifiable as a Human Carcinogen |
NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION
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STANDARD or SURVEY
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REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO CYCLOHEXYLAMINE-air
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10 hour time-weighted average 10 ppm
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NIOSH* DHHS #95-121,1995
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National Occupational Hazard Survey 1974
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National Occupational Hazard Survey 1974: Hazard Code: 84526; | Number of Industries 63; Total Number of Facilities 3,468; Number of Occupations 25; Total Number of Employees Exposed 9,450
National Occupational Exposure Survey 1983
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National Occupational Exposure Survey 1983: Hazard Code: 84526 |
![]() Number of Industries 83; Total Number of Facilities 4,729; Number of Occupations 47; Total Number of Employees Exposed 64,346; Total Number of Female Employees Exposed 2,914 |
STATUS IN FEDERAL AGENCIES:
ORGANIZATION
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REFERENCE
EPA GENETOX PROGRAM 1988, Positive: Cell transform.-SA7/SHE; Cytogenetics-male germ cell
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EPA GENETOX PROGRAM 1988, Positive/dose response: In vitro cytogenetics-nonhuman
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EPA GENETOX PROGRAM 1988, Negative: In vivo cytogenetics-nonhuman bone marrow
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EPA GENETOX PROGRAM 1988, Negative: In vitro cytogenetics-human lymphocyte
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EPA GENETOX PROGRAM 1988, Negative: D melanogaster-reciprocal translocation
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EPA GENETOX PROGRAM 1988, Negative: D melanogaster Sex-linked lethal
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EPA GENETOX PROGRAM 1988, Inconclusive: Carcinogenicity-mouse/rat
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EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster-whole sex chrom. loss
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EPA GENETOX PROGRAM 1988, Inconclusive: Rodent dominant lethal; Host-mediated assay
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EPA GENETOX PROGRAM 1988, Inconclusive: E coli polA without S9
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EPA TSCA Section 8(b) CHEMICAL INVENTORY
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Used in water treatment, also used in rubber production to retard degradation
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EPA TSCA Section 8(d) unpublished health/safety studies
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On EPA IRIS database
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EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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REFERENCES:
CODEN
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REFERENCE
85GMAT
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"Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F.,
et al., Moscow, Centre of International Projects, GKNT, 1982
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85JCAE
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"Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia,
Avicenum, 1986
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AETODY
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Advances in Modern Environmental Toxicology. (Senate Press, Inc., P.O. Box 252, Princeton
Junction, NJ 08550) V.1- 1980-
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AIHAAP
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American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH
44311) V.19- 1958-
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AMESES
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Abstracts of the Annual Meeting, Environmental Mutagen Society. (Environmental Mutagen Soc.,
1340 Old Chain Bridge Rd., Suite 300, McLean, VA 22101)
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AMIHBC
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AMA Archives of Industrial Hygiene and Occupational Medicine. (Chicago, IL) V.2-10, 1950-54.
For publisher information, see AEHLAU.
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DTLVS*
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The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by
American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
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EXMPA6
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Experimental and Molecular Pathology. (Academic Press, Inc., 1 E. First St., Duluth, MN
55802) V.1- 1962-
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FCTXAV
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Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see
FCTOD7.
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GTPZAB
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Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see
MTPEEI
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IECHAD
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Industrial and Engineering Chemistry. (Washington, DC) V.15-62, 1923-70. For publisher
information, see CHMTBL.
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IMEMDT
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IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications
Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
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IMSUAI
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Industrial Medicine and Surgery. (Northbrook, IL) V.18-42, 1949-73. For publisher
information, see IOHSA5.
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IMSUDL
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IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210) No.1- 1979-
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INHEAO
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Industrial Health. (National Institute of Industrial Health, 6-21-1 Nagao, Tama-ku, Kawasaki,
213 Japan) V.1- 1963-
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IPSTB3
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International Polymer Science and Technology. (Rapra Technology Ltd., Shawbury, Shrewsbury,
Shropshire SY4 4NR, UK)
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MUREAV
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Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1-
1964-
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NIOSH*
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National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and
Welfare, Reports and Memoranda.
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NTIS**
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National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse
for Scientific & Technical Information.
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NYKZAU
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Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto
Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40-
1944-
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PCBRD2
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Progress in Clinical and Biological Research. (Alan R. Liss, Inc., 41 E. 11th St., New York,
NY 10003) V.1- 1975-
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PCJOAU
|
Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub.
Corp., 233 Spring St., New York, NY 10013) No.1- 1967-
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SCIEAS
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Science. (American Assoc. for the Advancement of Science, 1333 H St., NW, Washington, DC
20005) V.1- 1895-
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SEIJBO
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Senten Ijo. Congenital Anomalies. (Nippon Senten Ijo Gakkai, c/o Kinki Daigaku Igakubu
Kaibagaku Kyoshitsu, 380 Nishiyama, Sayama-cho, Mirami-Kawachi-gun, Osaka-fu, Japan) V.1-26,
1960-86. For publisher information, see CGANE7.
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TJADAB
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Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E.
11th St., New York, NY 10003) V.1- 1968-
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TXAPA9
|
Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802)
V.1- 1959-
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VOONAW
|
Voprosy Onkologii. Problems of Oncology. For English translation, see PONCAU. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-10, 1928-37; V.1- 1955-
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