The Registry of Toxic Effects of Chemical Substances

1 - Cyclohexene, 4 - vinyl -

RTECS #: GW6650000

CAS #: 100-40-3

UPDATE: November 2004 MW: 108.20 MF: C8H12


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. REPRODUCTIVE EFFECTS DATA:
  3. TUMORIGENIC DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. 1,2,3,4 - Tetrahydrostyrene
  2. 1 - Vinylcyclohex - 3 - ene
  3. 1 - Vinylcyclohexene - 3
  4. 4 - Ethenyl - 1 - cyclohexene
  5. 4 - Ethenylcyclohexene
  6. 4 - Vinyl - 1 - cyclohexene
  7. 4 - Vinylcyclohexene
  1. 4 - Vinylcyclohexene (ACGIH)
  2. 4 - Vinylcyclohexene - 1
  3. Butadiene dimer
  4. Cyclohexene, 4 - ethenyl -
  5. Cyclohexenylethylene
  6. NCI - C54999


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lowest published toxic dose: 24 gm/kg (30 day prior to copulation) Reproductive: Maternal effects: Ovaries, fallopian tubes TOXID9 12,433,1992
intraperitoneal
mouse 		lowest published toxic dose: 19,500 mg/kg (30 day prior to copulation) Reproductive: Maternal effects: Ovaries, fallopian tubes TXAPA9 119,302,1993
oral
mouse 		lowest published toxic dose: 500 mg/kg (multigenerations) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) NTIS** PB91211250


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 103 gm/kg/2 year- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Reproductive: Tumorigenic effects: Ovarian tumors 		JTEHD6 21,507,1987
oral
mouse 		toxic dose : 103 gm/kg/2 year- intermittent Tumorigenic: Neoplastic by RTECS criteria

Reproductive: Tumorigenic effects: Ovarian tumors 		NTPTR* NTP-TR-303,1986
oral
mouse 		toxic dose : 206 gm/kg/2 year- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Blood: Lymphoma including Hodgkin's disease 		NTPTR* NTP-TR-303,1986
oral
mouse 		lowest published toxic dose: 206,000 mg/kg/103 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Blood: Lymphoma including Hodgkin's disease 		NTIS** PB87-116182
oral
mouse 		lowest published toxic dose: 103,000 mg/kg/103 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Reproductive: Tumorigenic effects: Ovarian tumors 		NTIS** PB87-116182
oral
rat 		lowest published toxic dose: 103,000 mg/kg/102 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Reproductive: Other reproductive system tumors 		NTIS** PB87-116182
skin
mouse 		lowest published toxic dose: 16 gm/kg/54 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Skin and Appendages: Tumors

Tumorigenic: Tumors at site of application 		JNCIAM 31,41,1963


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mouse 		lethal concentration (50 percent kill): 27 gm/m3 N/R IMEMDT 11,279,1976
inhalation
rat 		lowest published lethal concentration: 8,000 ppm/4 hour N/R AIHAAP 30,470,1969
oral
rat 		lethal dose (50 percent kill): 3,080 µL/kg N/R AIHAAP 30,470,1969
skin
rabbit 		lethal dose (50 percent kill): 20 mL/kg N/R AIHAAP 30,470,1969


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mouse 		lowest published toxic concentration: 1,000 ppm/6 hour/4 week- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field TOXID9 15,182,1995
inhalation
mouse 		lowest published toxic concentration: 1,000 ppm/6 hour/13 week- intermittent Blood: Pigmented or nucleated red blood cells

Blood: Changes in erythrocyte (RBC) count

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		FAATDF 32,1,1996
inhalation
mouse 		lowest published toxic concentration: 1,500 ppm/6 hour/2 week- intermittent Behavioral: Tremor

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		NTIS** OTS0556756
inhalation
rat 		lowest published toxic concentration: 1,500 ppm/6 hour/13 week- intermittent Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		FAATDF 32,1,1996
inhalation
rat 		lowest published toxic concentration: 1,500 ppm/6 hour/2 week- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		NTIS** OTS0556756
intraperitoneal
mouse 		lowest published toxic dose: 19,500 mg/kg/30 day- intermittent Reproductive: Maternal effects: Oogenesis TXAPA9 119,302,1993
intraperitoneal
mouse 		lowest published toxic dose: 24,000 mg/kg/30 day- intermittent Reproductive: Maternal effects: Oogenesis

Reproductive: Maternal effects: Menstrual cycle changes or disorders 		BIREBV 42,67,1990
intraperitoneal
mouse 		lowest published toxic dose: 3,000 mg/kg/30 day- intermittent Reproductive: Maternal effects: Ovaries, fallopian tubes REPTED 5,379,1991
oral
mouse 		lowest published toxic dose: 17,500 mg/kg/14 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field JTEHD6 21,493,1987
oral
mouse 		lowest published toxic dose: 78 gm/kg/13 week- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field JTEHD6 21,493,1987
oral
mouse 		lowest published toxic dose: 63,000 mg/kg/18 week- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain NTIS** PB91211250
oral
rat 		lowest published toxic dose: 17,500 mg/kg/14 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field NTPTR* NTP-TR-303,1986
oral
rat 		lowest published toxic dose: 52 gm/kg/13 week- intermittent Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		JTEHD6 21,493,1987


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.1 ppm DTLVS* TLV/BEI,2003
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Confirmed Animal Carcinogen with Unknown DTLVS* TLV/BEI,2003
International Agency for Research on Cancer (IARC) Cancer Review Animal Limited Evidence IMEMDT 39,181,1986
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 60,347,1994
International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Data IMEMDT 39,181,1986
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 60,347,1994
International Agency for Research on Cancer (IARC) Cancer Review Group 2B IMEMDT 60,347,1994
TOXICOLOGY REVIEW
MUREAV 543,201,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - POLAND MAC(time-weighted average) 10 mg/m3, JAN1999
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 0.4 mg/m3, 2003


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
N/R N/R N/R


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as an intermediate for the production of VINYLCYCLOHEXENE DIOXIDE
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0293-8735
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Studies (gavage);clear evidence:mouse
NCI Carcinogenesis Studies (gavage);inadequate study:rat


REFERENCES:

CODEN
REFERENCE
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958-
BIREBV Biology of Reproduction. (Soc. for the Study of Reproduction, 309 W. Clark St., Champaign, IL 61820) V.1- 1969-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
JNCIAM Journal of the National Cancer Institute. (Washington, DC) V.1-60, 1940-78. For publisher information, see JJIND8.
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206-
REPTED Reproductive Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-

Used as an intermediate for the production of VINYLCYCLOHEXENE DIOXIDE

NIOSH PROFILE (ALKENES, CYCLIC), SRC, 4/78

RTECS Compound Description:
   Tumorigen
   Reproductive Effector

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