The Registry of Toxic Effects of Chemical Substances

4 - Cyclohexene - 1,2 - dicarboximide, N - (trichloromethyl) thio -

RTECS #: GW5075000

CAS #: 133-06-2

UPDATE: February 2005 MW: 300.59 MF: C9H8Cl3NO2S


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. TUMORIGENIC DATA:
  6. ACUTE TOXICITY DATA:
  7. OTHER MULTIPLE DOSE DATA:
  8. REVIEWS:
  9. STANDARDS AND REGULATIONS:
  10. NIOSH DOCUMENTATION AND SURVEILLANCE:
  11. STATUS IN FEDERAL AGENCIES:
  12. REFERENCES:

SYNONYMS:

  1. 1,2,3,6 - Tetrahydro - N - (trichloromethylthio) phthalimide
  2. 1H - Isoindole - 1,3 (2H) - dione, 3a,4,7,7a - tetrahydro - 2 - ( (trichloromethyl) thio) -
  3. 3a,4,7,7a - Tetrahydro - N - (trichloromethanesulphenyl) phthalimide
  4. Aacaptan
  5. Agrosol S
  6. Agrox 2 - way and 3 - way
  7. Amercide
  8. Bangton
  9. Bean Seed Protectant
  10. Captab
  11. Captaf
  12. Captaf 85W
  13. Captan
  14. Captan (ACGIH)
  15. Captan 50W
  16. Captan - streptomycin 7.5 - 0.1 potato seed piece protectant
  17. Captancapteneet 26,538
  18. Captane
  19. Captex
  20. ENT 26,538
  21. Essofungicide 406
  22. FLIT 406
  23. Fungus ban type II
  24. Glyodex 3722
  25. Granox PFM
  26. Gustafson captan 30 - DD
  27. Hexacap
  28. Kaptan
  29. LE Captane (French)
  30. Malipur
  1. Merpan
  2. Micro - check 12
  3. N - ( (Trichloromethyl) thio) - 4 - cyclohexene - 1,2 - dicarboximide
  4. N - ( (Trichloromethyl) thio) tetrahydrophthalimide
  5. N - (Trichlor - methylthio) - phthalimid (German)
  6. N - (Trichloromethylmercapto) - delta (sup 4) - tetrahydrophthalimide
  7. N - (Trichloromethylthio) cyclohex - 4 - ene - 1,2 - dicarboximide
  8. N - (trichloromethylthio) - 4 - cyclohexane - 1,2 - dicarboximide
  9. N - Trichloromethylmercapto - 4 - cyclohexene - 1,2 - dicarboximide
  10. N - Trichloromethylthio - 3a,4,7,7a - tetrahydrophthalimide
  11. N - Trichloromethylthio - cis - delta (sup 4) - cyclohexene - 1,2 - dicarboximide
  12. N - Trichloromethylthiocyclohex - 4 - ene - 1,2 - dicarboximide
  13. NCI - C00077
  14. Neracid
  15. Orthocide
  16. Orthocide 406
  17. Orthocide 50
  18. Orthocide 7.5
  19. Osocide
  20. SR406
  21. Stauffer captan
  22. Trichlormethylthioamid kyseliny 1,2,3,6 - tetrahydroftalove (Czech)
  23. Trichloromethylthio - 1,2,5,6 - tetrahydrophthalamide
  24. Vancide 89
  25. Vancide 89RE
  26. Vancide P - 75
  27. Vangard K
  28. Vanguard K
  29. Vanicide
  30. Vondcaptan


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
skin
human 		0.5%/48 hour CODEDG 17,212,1987


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis hamster lung 10 mg/L AMONDS 3,253,1980
cytogenetic analysis human lung 10 mg/L ANYAA9 160,344,1969
cytogenetic analysis mammal (species unspecified) kidney 1 mg/L ANYAA9 160,344,1969
cytogenetic analysis intraperitoneal
mouse 		250 mg/kg MUREAV 58,111,1978
cytogenetic analysis oral
mouse 		50 mg/kg CHYCDW 16,300,1982
cytogenetic analysis intraperitoneal
rat 		50 mg/kg EJGCA9 11,245,1982
dominant lethal test oral
mouse 		1,000 mg/kg/5 day FCTXAV 10,353,1972
dominant lethal test oral
rat 		500 mg/kg/5 day FCTXAV 10,353,1972
DNA damage human fibroblast 99 µmol/L EMMUEG 20,127,1992
DNA inhibition human lymphocyte 5 mg/L ARTODN 45,101,1980
DNA inhibition human HeLa cell 8,300 nmol/L MUREAV 92,427,1982
DNA inhibition mammal (species unspecified) lymphocyte 160 µmol/L PCBPBS 8,317,1978
DNA inhibition intraperitoneal
rat 		500 mg/kg EJGCA9 11,245,1982
DNA inhibition rat other cell types 800 µg/L ARTODN 45,101,1980
DNA repair Bacillus subtilis 20 µg/disc MUREAV 40,19,1976
DNA repair Escherichia coli 125 µg/disc JPFCD2 21,319,1986
unscheduled DNA synthesis human fibroblast 1 µmol/L MUREAV 42,161,1977
host-mediated assay mouse
Salmonella typhimurium 		1,500 mg/kg BIZNAT 91,311,1972
host-mediated assay mouse
Serratia marcescens 		1,500 mg/kg BIZNAT 91,311,1972
host-mediated assay mouse
Escherichia coli 		800 mg/kg MUREAV 32,3,1975
mutation in microorganisms Aspergillus nidulans 4 mg/L (-enzymatic activation step) MUREAV 176,29,1987
mutation in microorganisms Bacillus subtilis 50 µg/plate (+/-enzymatic activation step) JAFCAU 29,268,1981
mutation in microorganisms Escherichia coli 5 µg/plate (+/-enzymatic activation step) NTIS** PB268-647
mutation in microorganisms Escherichia coli 2 µg/plate/20 minute MUREAV 492,91,2001
mutation in microorganisms other microorganisms 1,000 ppm (-enzymatic activation step) MMAPAP 50,233,1973
mutation in microorganisms other microorganisms 200 µg/plate (-enzymatic activation step) MUREAV 57,277,1978
mutation in microorganisms Salmonella typhimurium 310 ng/plate (+enzymatic activation step) MUREAV 130,79,1984
mutation in microorganisms Salmonella typhimurium 5 µg/plate (-enzymatic activation step) NTIS** PB268-647
mutation in microorganisms Saccharomyes cerevisiae 1 gm/L/25 hour- continuous (-enzymatic activation step) ZAPOAK 9,77,1969
micronucleus test oral
mouse 		200 mg/kg/2 day- continuous ENVRAL 43,359,1987
micronucleus test multiple
non-mammalian species 		250 ppb MUREAV 292,83,1993
gene conversion and mitotic recombination Aspergillus nidulans 2 mg/plate MUREAV 46,395,1977
gene conversion and mitotic recombination Saccharomyes cerevisiae 30 ppm NTIS** PB268-647
mutation in mammalian somatic cells hamster lung 5 mg/L MUREAV 33,261,1975
mutation in mammalian somatic cells hamster ovary 250 µg/L ENMUDM 3,233,1981
mutation in mammalian somatic cells oral
mouse 		50 mg/kg CHYCDW 16,300,1982
morphological transform hamster kidney 2 mg/L TXCYAC 19,55,1981
other mutation test systems cattle liver 1 mmol/L CBINA8 56,289,1985
other mutation test systems Escherichia coli 5 mg/L MUREAV 131,101,1984
other mutation test systems Escherichia coli 500 µmol/L AECTCV 11,41,1982
other mutation test systems human lymphocyte 1 mg/L CYGEDX 17(1),29,1983
other mutation test systems mammal (species unspecified) kidney 4 mg/L ANYAA9 160,344,1969
other mutation test systems intraperitoneal
rat 		500 mg/kg EJGCA9 11,245,1982
phage inhibition capacity Escherichia coli 2,100 nmol/L MUREAV 182,193,1987
sister chromatid exchange hamster lung 6 µmol/L MUREAV 78,177,1980
sister chromatid exchange hamster ovary 950 pmol/L CNJGA8 22,681,1980
sister chromatid exchange human lymphocyte 10 µmol/L MUREAV 79,53,1980
sex chromosome loss and nondisjunction oral
Drosophila melanogaster 		2,000 ppm JPFCD2 15,867,1980
specific locus test hamster ovary 5.5 mg/L/9 day EMMUEG 16,260,1990
sperm morphology unreported route
mouse 		1 gm/kg/5 day- continuous ENVRAL 43,359,1987


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
rat 		lowest published toxic dose: 25 mg/kg (14 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Extra embryonic structures (e.g., placenta, umbilical cord) 		CRSBAW 168,1173,1974
intraperitoneal
rat 		lowest published toxic dose: 25 mg/kg (6 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Specific developmental abnormalities: Eye, ear 		CRSBAW 168,1173,1974
oral
dog 		lowest published toxic dose: 1,890 mg/kg (1-63 day pregnant) Reproductive: Effects on newborn: Stillbirth 32OAAP -,253,1973
oral
hamster 		lowest published toxic dose: 300 mg/kg (8 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system TXAPA9 16,24,1970
oral
hamster 		lowest published toxic dose: 3,750 mg/kg (1-15 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) TXAPA9 13,420,1968
oral
hamster 		lowest published toxic dose: 200 mg/kg (8 day pregnant) Reproductive: Effects on embryo or fetus: Fetal death TXAPA9 16,24,1970
oral
hamster 		lowest published toxic dose: 750 mg/kg (7 day pregnant) Reproductive: Specific developmental abnormalities: Central nervous system TXAPA9 16,24,1970
oral
mouse 		lowest published toxic dose: 900 mg/kg (9-14 day pregnant) Reproductive: Effects on embryo or fetus: Extra embryonic structures (e.g., placenta, umbilical cord) NTIS** PB223-160
oral
mouse 		lowest published toxic dose: 250 mg/kg (5 day male) Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)

Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) 		TXAPA9 23,277,1972
oral
rat 		lowest published toxic dose: 500 mg/kg (5 day male) Reproductive: Effects on embryo or fetus: Fetal death FCTXAV 10,353,1972
oral
rat 		lowest published toxic dose: 2,500 mg/kg (6-10 day pregnant) Reproductive: Maternal effects: Uterus, cervix, vagina BECTA6 33,84,1984
oral
rat 		lowest published toxic dose: 25 gm/kg (6-10 day pregnant) Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth) BECTA6 33,84,1984
oral
rabbit 		lowest published toxic dose: 244 mg/kg (6-18 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) TXAPA9 13,420,1968
subcutaneous
mouse 		lowest published toxic dose: 900 mg/kg (9-14 day pregnant) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on embryo or fetus: Fetal death 		NTIS** PB223-160
subcutaneous
mouse 		lowest published toxic dose: 900 mg/kg (9-14 day pregnant) Reproductive: Effects on embryo or fetus: Extra embryonic structures (e.g., placenta, umbilical cord)

Reproductive: Specific developmental abnormalities: Eye, ear

Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue) 		NTIS** PB223-160
unreported route
rat 		lowest published toxic dose: 105 mg/kg (10-16 day pregnant) Reproductive: Effects on fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated)

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on newborn: Sex ratio 		SAKNAH 64,737,1971


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 1,075 gm/kg/80 week- continuous Tumorigenic: Neoplastic by RTECS criteria

Gastrointestinal: Tumors 		NCITR* NCI-TR-15,1977
oral
mouse 		toxic dose : 540 gm/kg/80 week- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Gastrointestinal: Tumors 		NCITR* NCI-TR-15,1977
oral
mouse 		lowest published toxic dose: 1,075,200 mg/kg/80 week- continuous Tumorigenic: Neoplastic by RTECS criteria

Gastrointestinal: Tumors 		JEPOEC 9,127,1989
oral
rat 		lowest published toxic dose: 84,840 mg/kg/80 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Endocrine: Tumors 		JEPOEC 9,127,1989
oral
rat 		lowest published toxic dose: 70,140 mg/kg/80 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Endocrine: Tumors

Reproductive: Tumorigenic effects: Ovarian tumors 		JEPOEC 9,127,1989


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mouse 		lethal concentration (50 percent kill): 4,500 mg/m3/2 hour N/R TXAPA9 45,320,1978
inhalation
rat 		lethal concentration (50 percent kill): >5,700 mg/m3/2 hour N/R TXAPA9 45,320,1978
intraperitoneal
mouse 		lethal dose (50 percent kill): 30 mg/kg N/R ZMMPAO 234,110,1976
intraperitoneal
rat 		lowest published lethal dose: 25 mg/kg Peripheral Nerve and Sensation: Spastic paralysis with/without sensory change

Behavioral: Sleep

Behavioral: Fluid intake 		CRSBAW 168,1173,1974
oral
human 		lowest published lethal dose: 1,071 mg/kg N/R 34ZIAG -,151,1969
oral
mouse 		lethal dose (50 percent kill): 7 gm/kg N/R TXAPA9 45,320,1978
oral
rat 		lethal dose (50 percent kill): 9 gm/kg N/R FMCHA2 -,C59,1991
skin
rat 		lethal dose (50 percent kill): >5 gm/kg N/R FAATDF 7,299,1986
unreported route
domestic bird 		lowest published lethal dose: >100 mg/kg N/R PEMNDP 9,119,1991
unreported route
mouse 		lethal dose (50 percent kill): 138 mg/kg N/R GISAAA 38(10),24,1973
unreported route
rat 		lethal dose (50 percent kill): 2,650 mg/kg N/R GISAAA 38(10),24,1973
unreported route
rabbit 		lethal dose (50 percent kill): 740 mg/kg N/R GISAAA 38(10),24,1973


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 695,289 mg/kg/113 week- continuous Gastrointestinal: Tumors HBPTO* 1,814,2001
oral
mouse 		lowest published toxic dose: 42,180 mg/kg/570 day- continuous Liver: Tumors JEPOEC 9,127,1989
oral
mouse 		lowest published toxic dose: 598,500 mg/kg/95 week- continuous Gastrointestinal: Tumors HBPTO* 1,814,2001
oral
rat 		lowest published toxic dose: 64,120 mg/kg/14 week- intermittent Behavioral: Food intake (animal)

Kidney, Ureter, and Bladder: Urine volume increased

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		APTOA6 29,226,1971
oral
rat 		lowest published toxic dose: 7,280 mg/kg/1 year- intermittent Kidney, Ureter, and Bladder: Other changes in urine composition

Blood: Pigmented or nucleated red blood cells

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases 		GISAAA 38(9),24,1973
oral
rat 		lowest published toxic dose: 84,840 mg/kg/80 week- continuous Cardiac: Tumors

Kidney, Ureter, and Bladder: Other changes

Reproductive: Paternal effects: Testes, epididymis, sperm duct 		JEPOEC 9,127,1989
oral
rat 		lowest published toxic dose: 70,140 mg/kg/80 week- continuous Liver: Tumors JEPOEC 9,127,1989


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 5 mg/m3 (sen) ( intermittent) DTLVS* TLV/BEI,2003
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Confirmed Animal Carcinogen with Unknown DTLVS* TLV/BEI,2003
International Agency for Research on Cancer (IARC) Cancer Review Animal Limited Evidence IMEMDT 30,295,1983
International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Data IMEMDT 30,295,1983
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMSUDL 7,56,1987
TOXICOLOGY REVIEW
MUREAV 557,109,2004
TOXICOLOGY REVIEW
CNDQA8 10(3),43,1975
TOXICOLOGY REVIEW
MUREAV 562,77,2004


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Supported RBREV* -,94,1998
Occupational Exposure Limit - AUSTRALIA time-weighted average 5 mg/m3, JAN1993
Occupational Exposure Limit - BELGIUM time-weighted average 5 mg/m3, JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 5 mg/m3, JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 5 mg/m3, JAN1999
Occupational Exposure Limit - FRANCE VME 5 mg/m3, continuous3 Carcinogen, JAN1999
Occupational Exposure Limit - NORWAY time-weighted average 5 mg/m3, JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 5 mg/m3, JAN1999
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 5 mg/m3, 2003
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Confirmed Animal Carcinogen with Unknown
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Confirmed Animal Carcinogen with Unknown


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO CAPTAN-air Carcinogen;
10 hour time-weighted average 5 mg/m3 		NIOSH* DHHS #95-121,1995
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 84027;
Number of Industries 4;
Total Number of Facilities 189;
Number of Occupations 16;
Total Number of Employees Exposed 1,059
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 84027;
Number of Industries 3;
Total Number of Facilities 66;
Number of Occupations 3;
Total Number of Employees Exposed 1,069;
Total Number of Female Employees Exposed 778


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Positive: Aspergillus-recombination; Rodent dominant lethal
EPA GENETOX PROGRAM 1988, Positive: Host-mediated assay; B subtilis rec assay
EPA GENETOX PROGRAM 1988, Positive: E coli polA without S9; Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Positive: D melanogaster Sex-linked lethal
EPA GENETOX PROGRAM 1988, Positive: V79 cell culture-gene mutation; TRP reversion
EPA GENETOX PROGRAM 1988, Positive: S cerevisiae gene conversion; S cerevisiae-homozygosis
EPA GENETOX PROGRAM 1988, Weakly Positive: TRP reversion
EPA GENETOX PROGRAM 1988, Positive/limited: Carcinogenicity-mouse/rat
EPA GENETOX PROGRAM 1988, Negative: Aspergillus-aneuploidy; Body fluid assay
EPA GENETOX PROGRAM 1988, Negative: Rodent heritable translocation
EPA GENETOX PROGRAM 1988, Negative: In vitro UDS-human fibroblast
EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster-reciprocal translocation
EPA GENETOX PROGRAM 1988, Positive: CHO gene mutation
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as an agricultural fungicide and as a perservative in cosmetics
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Bioassay (feed);clear evidence:mouse NCITR* NCI-TR-15,1977
NCI Carcinogenesis Bioassay (feed);no evidence:rat NCITR* NCI-TR-15,1977


REFERENCES:

CODEN
REFERENCE
32OAAP "Pesticide and the Environment: a Continuing Controversy, Selected Papers Presented and Papers Reviewed at the 8th Inter-American Conference on Toxicology and Occupational Medicine, Miami, FL, 1973," Deichmann, W.B., ed., New York, Stratton Intercontinental Medical Book Corp., 1973
34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969
AECTCV Archives of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 070944) V.1- 1973-
AMONDS Applied Methods in Oncology. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1978-
ANYAA9 Annals of the New York Academy of Sciences. (New York Academy of Sciences, 2 E. 63rd St., New York, NY 10021) V.1- 1877-
APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974-
BECTA6 Bulletin of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1966-
BIZNAT Biologisches Zentralblatt. (VEB Georg Thieme, Postfach 946, Leipzig DDR-7010, Ger. Dem. Rep.) V.1- 1881-
CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1969-
CHYCDW Zhonghua Yufangyixue Zazhi. Chinese Journal of Preventive Medicine. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) Beginning history not known.
CNDQA8 Cahiers de Nutrition et de Dietetique. (Editions Meteore, 42, rue du Louvre, 75001 Paris, France) V.1- 1966-
CNJGA8 Canadian Journal of Genetics and Cytology. (National Research Council of Canada, Publication Sales and Distribution, Ottawa ON K1A OR6, Canada) V.1- 1959-
CODEDG Contact Dermatitis. Environmental and Occupational Dermatitis. (Munksgaard International Pub., c/o Publications Expediting Inc., 200 Meacham Ave., Elmont, NY 11003) V.1- 1975-
CRSBAW Comptes Rendus des Seances de la Societe de Biologie et de Ses Filiales. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1849-
CYGEDX Cytology and Genetics (English Translation). Translation of TGANAK. (Allerton Press Inc., 150 Fifth Ave., New York, NY 10011) V.8- 1974-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EJGCA9 Egyptian Journal of Genetics and Cytology. (Egyptian Soc. of Genetics, c/o Alexandria Univ., Faculty of Agriculture, Dept. of Genetics, Alexandria, Egypt) V.1- 1972-
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG.
ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1967-
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7.
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
FMCHA2 Farm Chemicals Handbook. (Meister Pub., 37841 Euclid Ave., Willoughy, OH 44094)
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
HBPTO* Handbook of pesticide toxicology. Robert Krieger ed, Academic press, 2001
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979-
JAFCAU Journal of Agricultural and Food Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1953-
JEPOEC Journal of Environmental Pathology, Toxicology and Oncology. (Chem-Orbital, POB 134, Park Forest, IL 60466) V.5(4)- 1984-
JPFCD2 Journal of Environmental Science and Health, Part B: Pesticides, Food Contaminants, and Agricultural Wastes. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.B11- 1976-
MMAPAP Mycopathologia et Mycologia Applicata. (The Hague, Netherlands) V.5-54(4), 1950-74. For publisher information, see MYCPAH.
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NCITR* National Cancer Institute Carcinogenesis Technical Report Series. (Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
PCBPBS Pesticide Biochemistry and Physiology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1971-
PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968-
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
SAKNAH Soobshcheniia Akademii Nauk Gruzinskoi SSR. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1941-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-
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Used as an agricultural fungicide and as a perservative in cosmetics

FDA-over the counter drug

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Mutagen
   Reproductive Effector
   Human Data
   Hormone
   Primary Irritant

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