The Registry of Toxic Effects of Chemical Substances

4 - Cyclohexene - 1,2 - dicarboximide, N - ( (1,1,2,2 - tetrachloroethyl) thio) -

RTECS #: GW4900000

CAS #: 2425-06-1

UPDATE: May 2004 MW: 349.06 MF: C10H9Cl4NO2S


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. TUMORIGENIC DATA:
  6. ACUTE TOXICITY DATA:
  7. OTHER MULTIPLE DOSE DATA:
  8. REVIEWS:
  9. STANDARDS AND REGULATIONS:
  10. NIOSH DOCUMENTATION AND SURVEILLANCE:
  11. STATUS IN FEDERAL AGENCIES:
  12. REFERENCES:

SYNONYMS:

  1. Alfloc 7020
  2. Alfloc 7046
  3. Arborseal
  4. Captafol
  5. Captafol (ACGIH)
  6. CS5623
  7. 1H - Isoindole - 1,3 (2H) - dione, 3a,4,7,7a - tetrahydro - 2 - ( (1,1,2,2 - tetrachloroethyl) thio) - (9CI)
  8. Difolatan
  9. Difolatan 80W
  10. Difolatan BOW
  11. Difolatan 4F
  12. Difosan
  13. Foltaf
  14. Folcid
  1. Haipen 50
  2. Merpafol
  3. Nalco 7046
  4. Ortho 5865
  5. Proxel EF
  6. Sanspor
  7. Santar SM
  8. Terrazol
  9. N - (1,1,2,2 - Tetrachloraethylthio) - cyclohex - 4 - en - 1,4 - diacarboximid (German)
  10. N - (1,1,2,2 - Tetrachloraethylthio) - tetrahydrophthalamid (German)
  11. N - 1,1,2,2 - Tetrachloroethylmercapto - 4 - cyclohexene - 1,2 - carboximide
  12. N - ( (1,1,2,2 - Tetrachloroethyl) sulfenyl) - cis - 4 - cyclohexene - 1,2 - dicarboximide
  13. N - (1,1,2,2 - Tetrachloroethylthio) - 4 - cyclohexene - 1,2 - dicarboximide
  14. 3a,4,7,7a - Tetrahydro - N - (1,1,2,2 - tetrachloroethanesulphenyl) phthalimide


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
skin
human 		0.5%/48 hour CODEDG 17,212,1987


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis hamster lung 10 µmol/L MUREAV 78,177,1980
cytogenetic analysis human embryo 3,400 µg/L SNSHBT (20),574,1980
dominant lethal test intraperitoneal
rat 		25 mg/kg/5 day FCTXAV 10,353,1972
DNA inhibition human lymphocyte 5 mg/L ARTODN 45,101,1980
DNA inhibition rat other cell types 80 mg/L ARTODN 45,101,1980
DNA repair Bacillus subtilis 100 ng/disc MUREAV 40,19,1976
mutation in microorganisms Aspergillus nidulans 20 µg/plate (-enzymatic activation step) MUREAV 46,395,1977
mutation in microorganisms Escherichia coli 50 µg/plate (-enzymatic activation step) MUREAV 40,19,1976
mutation in microorganisms Escherichia coli 50 µg/plate (+enzymatic activation step) MUREAV 116,185,1983
mutation in microorganisms Salmonella typhimurium 100 µg/plate (+enzymatic activation step) EMCAE8 5,11,1985
micronucleus test hamster lung 3,400 µg/L SNSHBT (20),574,1980
micronucleus test human embryo 3,400 µg/L SNSHBT (20),574,1980
gene conversion and mitotic recombination Aspergillus nidulans 20 µg/plate MUREAV 46,395,1977
morphological transform oral
rat 		7,560 mg/kg/6 week CRNGDP 9,387,1988
other mutation test systems Escherichia coli 100 µg/L MUREAV 390,245,1997
sister chromatid exchange hamster lung 2 µmol/L MUREAV 78,177,1980
sister chromatid exchange human embryo 3,400 µg/L SNSHBT (20),574,1980


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
rat 		lowest published toxic dose: 500 mg/kg (5 day male) Reproductive: Effects on embryo or fetus: Fetal death FCTXAV 10,363,1972
oral
hamster 		lowest published toxic dose: 200 mg/kg (8 day pregnant) Reproductive: Effects on embryo or fetus: Fetal death

Reproductive: Specific developmental abnormalities: Musculoskeletal system 		TXAPA9 16,24,1970
oral
hamster 		lowest published toxic dose: 400 mg/kg (7 day pregnant) Reproductive: Specific developmental abnormalities: Central nervous system TXAPA9 16,24,1970
oral
rat 		lowest published toxic dose: 11 gm/kg (multigenerations) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) TXAPA9 13,420,1968
oral
rat 		lowest published toxic dose: 250 mg/kg (5 day male) Reproductive: Effects on embryo or fetus: Fetal death FCTXAV 10,363,1972
oral
rabbit 		lowest published toxic dose: 975 mg/kg (6-18 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) TXAPA9 13,420,1968


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 60,480 mg/kg/96 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Tumors

Liver: Tumors 		GANNA2 75,853,1984
oral
mouse 		toxic dose : 15,120 mg/kg/96 week- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Cardiac: Tumors

Gastrointestinal: Tumors 		JTSCDR 7,278,1982
oral
rat 		lowest published toxic dose: 65,520 mg/kg/2 year- continuous Tumorigenic: Carcinogenic by RTECS criteria

Kidney, Ureter, and Bladder: Kidney tumors 		JJCREP 81,1222,1990


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lowest published lethal dose: 3 mg/kg N/R FCTXAV 13,55,1975
oral
rat 		lethal dose (50 percent kill): 2,500 mg/kg N/R WRPCA2 9,119,1970
skin
rabbit 		lethal dose (50 percent kill): 15,400 mg/kg N/R WRPCA2 9,119,1970
unreported route
rat 		lethal dose (50 percent kill): >6 gm/kg N/R RREVAH 36,240,1971


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 45,360 mg/kg/12 week- continuous Liver: Other changes

Kidney, Ureter, and Bladder: Changes in bladder weight

Endocrine: Changes in spleen weight 		JTEHD6 38,69,1993
oral
rat 		lowest published toxic dose: 39,894.4 mg/kg/104 week- continuous Liver: Tumors HBPTO* 1,814,2001
oral
rat 		lowest published toxic dose: 39,894.4 mg/kg/104 week- continuous Kidney, Ureter, and Bladder: Kidney tumors HBPTO* 1,814,2001


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.1 mg/m3 (skin) DTLVS* TLV/BEI,2003
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not Classifiable as a Human Carcinogen DTLVS* TLV/BEI,2003
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 53,353,1991
International Agency for Research on Cancer (IARC) Cancer Review Human No Available Data IMEMDT 53,353,1991
International Agency for Research on Cancer (IARC) Cancer Review Group 2A IMEMDT 53,353,1991
TOXICOLOGY REVIEW
MUREAV 32,3,1975


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Cancelled RBREV* -,93,1998
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.1 mg/m3, JAN1993
Occupational Exposure Limit - BELGIUM time-weighted average 0.1 mg/m3, JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 0.1 mg/m3, Skin, JAN1999
Occupational Exposure Limit - FRANCE VME 0.1 mg/m3, Skin, Carcinogen, JAN1993
Occupational Exposure Limit - NORWAY time-weighted average 0.1 mg/m3, JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 0.1 mg/m3, Skin, JAN1999
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 0.1 mg/m3, Carcinogen, SEP2000


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO CAPTAFOL-air Carcinogen;
10 hour time-weighted average 0.1 mg/m3 (Sk) 		NIOSH* DHHS #95-121,1995
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: M2985;
Number of Industries 1;
Total Number of Facilities 59;
Number of Occupations 1;
Total Number of Employees Exposed 117


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Positive: Aspergillus-recombination; B subtilis rec assay
EPA GENETOX PROGRAM 1988, Positive: TRP reversion
EPA GENETOX PROGRAM 1988, Weakly Positive: TRP reversion
EPA GENETOX PROGRAM 1988, Negative: Aspergillus-aneuploidy; Host-mediated assay
EPA GENETOX PROGRAM 1988, Inconclusive: Rodent dominant lethal; Histidine reversion-Ames test
Used as a fungicide
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974-
CODEDG Contact Dermatitis. Environmental and Occupational Dermatitis. (Munksgaard International Pub., c/o Publications Expediting Inc., 200 Meacham Ave., Elmont, NY 11003) V.1- 1975-
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EMCAE8 Environmental Mutagens and Carcinogens. (Korean Environmental Mutagen Soc., c/o Dept. of Zoology, Seoul National Univ., Seoul 151, S. Korea) V.1- 1981-
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7.
GANNA2 Gann. Japanese Journal of Cancer Research. (Tokyo, Japan) V.1-75, 1907-84. For publisher information, see JJCREP.
HBPTO* Handbook of pesticide toxicology. Robert Krieger ed, Academic press, 2001
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
JJCREP Japanese Journal of Cancer Research. (Elsevier Science Pub. BV, POB 211, 1000 AE Amsterdam, Netherlands) V.76- 1985-
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of Toxicological Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku, Tokyo 113, Japan) V.1- 1976-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
RREVAH Residue Reviews. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1962-
SNSHBT Senshokutai. Chromosome. (Sensyokutai Gakkai, Kaokusai Kirisutokyo Daigaku, Mitaka, Tokyo-to, Japan) No.1- 1946- Adopted new numbering in 1976.
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
WRPCA2 World Review of Pest Control. (London, UK) V.1-10, 1962-71. Discontinued.

Used as a fungicide

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Mutagen
   Reproductive Effector
   Hormone
   Primary Irritant

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