The Registry of Toxic Effects of Chemical Substances

Cyclohexanol, methyl -

RTECS #: GW0175000

CAS #: 25639-42-3

UPDATE: November 2004 MW: 114.21 MF: C7H14O


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. ACUTE TOXICITY DATA:
  3. REVIEWS:
  4. STANDARDS AND REGULATIONS:
  5. NIOSH DOCUMENTATION AND SURVEILLANCE:
  6. STATUS IN FEDERAL AGENCIES:
  7. REFERENCES:

SYNONYMS:

  1. Hexahydrocresol
  2. Hexahydromethylphenol
  3. Methylcyclohexanol
  1. Methylcyclohexanol (ACGIH:OSHA)
  2. Methylhexalin
  3. Metylocykloheksanol (Polish)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
human 		lowest published toxic concentration: 500 ppm Behavioral: Antipsychotic

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes 		TGNCDL 2,55,1961
oral
rat 		lethal dose (50 percent kill): 1,660 mg/kg N/R JIHTAB 25,415,1943
oral
rabbit 		lowest published lethal dose: 1,750 mg/kg N/R HBTXAC 1,194,1955
subcutaneous
rat 		lethal dose (50 percent kill): 2,900 mg/kg N/R JIHTAB 25,415,1943
skin
rabbit 		lowest published lethal dose: 6,800 mg/kg N/R HBTXAC 1,194,1955


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 50 ppm DTLVS* TLV/BEI,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 50 ppm (235 mg/m3) DTLWS* 3,23,1973
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 100 ppm (470 mg/m3) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 100 ppm (470 mg/m3) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 100 ppm (470 mg/m3) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 100 ppm (470 mg/m3) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 50 ppm (235 mg/m3), JAN1993
Occupational Exposure Limit - BELGIUM time-weighted average 50 ppm (234 mg/m3), JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 50 ppm (235 mg/m3), JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 50 ppm (235 mg/m3), short term exposure limit 75 ppm (355 mg/m3), JAN1993
Occupational Exposure Limit - FRANCE VME 50 ppm (235 mg/m3), JAN1999
Occupational Exposure Limit - GERMANY MAK 50 ppm (235 mg/m3), JAN1999
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 50 ppm (230 mg/m3), JAN1999
Occupational Exposure Limit - NORWAY time-weighted average 25 ppm (115 mg/m3), JAN1999
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 50 mg/m3, Skin, 2003
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 100 ppm (470 mg/m3), JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 50 mg/m3, MAC(short term exposure limit) 350 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA time-weighted average 50 ppm, JAN1993
Occupational Exposure Limit - SWITZERLAND MAK- week 50 ppm (235 mg/m3), KZG- week 100 ppm (470 mg/m3),JAN1999
Occupational Exposure Limit - TURKEY time-weighted average 100 ppm (470 mg/m3), JAN1993
Occupational Exposure Limit - UNITED KINGDOM LTEL 50 ppm (235 mg/m3), short term exposure limit 75 ppm, JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 50 ppm (237 mg/m3), short term exposure limit 75 ppm, SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 50 ppm
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 50 ppm


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO METHYLCYCLOHEXANOL-air 10 hour time-weighted average 50 ppm NIOSH* DHHS #92-100,1992


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
NIOSH Analytical Method, 1994: Methylcyclohexanol, 1404


REFERENCES:

CODEN
REFERENCE
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
DTLWS* "Documentation of the Threshold Limit Values for Substances in Workroom Air," Supplements. For publisher information, see 85INA8.
HBTXAC "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU.
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
TGNCDL "Handbook of Organic Industrial Solvents," 2nd ed., Chicago, National Assoc. of Mutual Casualty Companies, 1961

NIOSH PROFILE (ALCOHOLS), SRI, 2/77

RTECS Compound Description:
   Human Data

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