The Registry of Toxic Effects of Chemical Substances

Cyclohexene

RTECS #: GW2500000

CAS #: 110-83-8

UPDATE: November 2004 MW: 82.16 MF: C6H10


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. ACUTE TOXICITY DATA:
  3. OTHER MULTIPLE DOSE DATA:
  4. REVIEWS:
  5. STANDARDS AND REGULATIONS:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. Benzenetetrahydride
  2. Benzene, tetrahydro -
  3. Cyclohexene (ACGIH:OSHA)
  4. Cyclohex - 1 - ene
  1. Cykloheksen (Polish)
  2. Hexanaphthylene
  3. Tetrahydrobenzene
  4. 1,2,3,4 - Tetrahydrobenzene


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mouse 		lowest published toxic concentration: 30,000 mg/m3 Behavioral: General anesthetic VCVGH* -,95,1990
inhalation
mouse 		lethal concentration (50 percent kill): 50,000 mg/m3 Vascular: BP lowering not characterized in autonomic section

Lung, Thorax, or Respiration: Respiratory obstruction 		VCVGH* -,95,1990
inhalation
rat 		lethal concentration : >6,370 ppm/4 hour Behavioral: Tremor

Behavioral: Ataxia

Lung, Thorax, or Respiration: Other changes 		NTIS** OTS0555329
oral
mouse 		lethal dose (50 percent kill): >3,200 µL/kg Behavioral: Altered sleep time (including change in righting reflex)

Behavioral: Somnolence (general depressed activity)

Behavioral: Ataxia 		NTIS** OTS0546026
oral
mouse 		lethal dose (50 percent kill): 2,300 mg/kg N/R VCVGH* -,95,1990
oral
rat 		lethal dose (50 percent kill): 2,400 µL/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Tremor

Behavioral: Ataxia 		NTIS** OTS0546026
oral
rat 		lethal dose (50 percent kill): 1,300 mg/kg N/R VCVGH* -,95,1990
oral
rat 		lethal dose (16 percent kill): 920 mg/kg N/R VCVGH* -,95,1990
oral
rat 		lethal dose (84 percent kill): 3,800 mg/kg N/R VCVGH* -,95,1990
oral
rat 		lowest published toxic dose: 400 mg/kg Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Nutritional and Gross Metabolic: Changes in: Metabolic acidosis

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		VCVGH* -,95,1990
skin
guinea pig 		lethal dose (50 percent kill): >20 mL/kg N/R NTIS** OTS0556686
unreported route
rat 		lethal dose (50 percent kill): 2 gm/kg N/R GTPZAB 29(12),53,1985


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 600 ppm/6 hour/26 week- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases 		TXAPA9 37,155,1976


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 300 ppm DTLVS* TLV/BEI,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 300 ppm (1015 mg/m3) DTLVS* 3,66,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 300 ppm (1015 mg/m3) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 300 ppm (1015 mg/m3) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 300 ppm (1015 mg/m3) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 300 ppm (1015 mg/m3) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 300 ppm (1015 mg/m3), JAN1993
Occupational Exposure Limit - AUSTRIA MAK 300 ppm (1015 mg/m3), JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 300 ppm (1010 mg/m3), JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 300 ppm (1015 mg/m3), JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 300 ppm (1015 mg/m3), short term exposure limit 375 ppm (1270 mg/m3), JAN1999
Occupational Exposure Limit - FRANCE VME 300 ppm (1015 mg/m3), JAN1999
Occupational Exposure Limit - GERMANY MAK 300 ppm (1015 mg/m3), JAN1999
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 1015 mg/m3, 2003
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 300 ppm (1015 mg/m3), JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 300 mg/m3, MAC(short term exposure limit) 900 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA short term exposure limit 50 mg/m3, JAN1993
Occupational Exposure Limit - SWITZERLAND MAK- week 300 ppm (1015 mg/m3), KZG- week 600 ppm (2030 mg/m3), JAN1999
Occupational Exposure Limit - TURKEY time-weighted average 300 ppm (1050 mg/m3), JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 300 ppm (1020 mg/m3), SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 300 ppm
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 300 ppm


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO CYCLOHEXENE-air 10 hour time-weighted average 300 ppm NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 21705;
Number of Industries 1;
Total Number of Facilities 16;
Number of Occupations 7;
Total Number of Employees Exposed 529
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 21705;
Number of Industries 1;
Total Number of Facilities 40;
Number of Occupations 1;
Total Number of Employees Exposed 517;
Total Number of Female Employees Exposed 239


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as alkylation component
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Hydrocarbons, BP 36-126 degree C, 1500


REFERENCES:

CODEN
REFERENCE
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
VCVGH* "Vrednie chemichescie veshestva, galogenproisvodnie uglevodorodov". (Hazardous substances: Galogenated hydrocarbons) Bandman A.L. et al., Chimia, 1990.

Used as alkylation component

NIOSH PROFILE (ALKENES), SRI, 2/77

NIOSH PROFILE (ALKENES, CYCLIC), SRC, 4/78

NIOSH PROFILE (ALKENES), SRC, 4/78

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