The Registry of Toxic Effects of Chemical Substances

Cyclohexanone, 2 - methyl -

RTECS #: GW1750000

CAS #: 583-60-8

UPDATE: November 2004 MW: 112.19 MF: C7H12O


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. ACUTE TOXICITY DATA:
  3. REVIEWS:
  4. STANDARDS AND REGULATIONS:
  5. NIOSH DOCUMENTATION AND SURVEILLANCE:
  6. STATUS IN FEDERAL AGENCIES:
  7. REFERENCES:

SYNONYMS:

  1. 2 - Methyl - cyclohexanon (German, Dutch)
  2. alpha - Methylcyclohexanone
  1. o - Methylcyclohexanone


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published lethal concentration: 2,800 ppm/4 hour N/R AIHAAP 30,470,1969
intraperitoneal
mouse 		lethal dose (50 percent kill): 200 mg/kg N/R NTIS** AD691-490
intravenous
mouse 		lowest published lethal dose: 270 mg/kg Cardiac: Change in rate

Vascular: BP lowering not characterized in autonomic section 		COREAF 236,633,1953
oral
rat 		lethal dose (50 percent kill): 2,140 µL/kg N/R AIHAAP 30,470,1969
skin
rabbit 		lethal dose (50 percent kill): 1,770 µL/kg N/R AIHAAP 30,470,1969


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 50 ppm (skin) DTLVS* TLV/BEI,2002
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 50 ppm (skin);short term exposure limit 75 ppm (skin) DTLVS* TLV/BEI,2003
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 200 ppm;short term exposure limit 300 ppm DTLVS* TLV/BEI,2003
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value short term exposure limit 75 ppm (skin) DTLVS* TLV/BEI,2002


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 50 ppm (230 mg/m3) (skin) DTLWS* 3,23,1973
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 100 ppm (460 mg/m3) (skin) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 100 ppm (460 mg/m3) (skin) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 100 ppm (460 mg/m3) (skin) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 100 ppm (460 mg/m3) (skin) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 50 ppm (230 mg/m3), short term exposure limit 75 ppm, Skin, JAN1993
Occupational Exposure Limit - AUSTRIA MAK 50 ppm (230 mg/m3), Skin, JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 50 ppm (229 mg/m3), short term exposure limit 75 ppm (344 mg/m3), Skin, JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 50 ppm (230 mg/m3), Skin, JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 50 ppm (230 mg/m3), short term exposure limit 75 ppm (345 mg/m3), Skin, JAN1999
Occupational Exposure Limit - FRANCE VME 50 ppm (230 mg/m3), Skin, JAN1999
Occupational Exposure Limit - GERMANY MAK 50 ppm (230 mg/m3), Skin, JAN1999
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 50 ppm (230 mg/m3), Skin, JAN1999
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 230 mg/m3, Skin, 2003
Occupational Exposure Limit - NORWAY time-weighted average 25 ppm (115 mg/m3), JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 100 ppm (460 mg/m3), Skin, JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 50 mg/m3, MAC(short term exposure limit) 340 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA time-weighted average 50 ppm, JAN1993
Occupational Exposure Limit - SWITZERLAND MAK- week 50 ppm (230 mg/m3), KZG- week 100 ppm (470 mg/m3),Skin, JAN1999
Occupational Exposure Limit - TURKEY time-weighted average 100 ppm (460 mg/m3), Skin, JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 50 ppm (237 mg/m3), short term exposure limit 75 ppm, SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

short term exposure limit 75 ppm (skin)
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
short term exposure limit 75 ppm (skin)


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO THE CHEMICAL-air 10 hour time-weighted average 50 ppm (Sk);
short term exposure limit 75 ppm (Sk) 		NIOSH* DHHS #92-100,1992


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
NIOSH Analytical Method, 1994: Methylcyclohexanone, 2521


REFERENCES:

CODEN
REFERENCE
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
COREAF Comptes Rendus Hebdomadaires des Seances, Academie des Sciences. (Paris, France) V.1-261, 1835-1965. For publisher information, see CRASEV.
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
DTLWS* "Documentation of the Threshold Limit Values for Substances in Workroom Air," Supplements. For publisher information, see 85INA8.
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.

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