The Registry of Toxic Effects of Chemical Substances

Cyclohexanol

RTECS #: GV7875000

CAS #: 108-93-0

UPDATE: November 2004 MW: 100.18 MF: C6H12O


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. NIOSH DOCUMENTATION AND SURVEILLANCE:
  10. STATUS IN FEDERAL AGENCIES:
  11. REFERENCES:

SYNONYMS:

  1. Adronal
  2. Anol
  3. Cicloesanolo (Italian)
  4. Cyclohexyl alcohol
  5. Cykloheksanol (Polish)
  6. Cyclohexanol (ACGIH:OSHA)
  7. Hexahydrophenol
  1. Hexalin
  2. Hydralin
  3. Hydrophenol
  4. Hydroxycyclohexane
  5. Naxol
  6. Phenol, hexahydro -


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
human 		100 ppm N/R JIHTAB 25,282,1943
eye
rabbit 		100 無/24 hour moderate NTIS** OTS0572833
eye
rabbit 		100 無/24 hour mild NTIS** OTS0572832
eye
rabbit 		10 無 moderate JTPAE7 29,187,2001
skin
rabbit 		500 無/24 hour moderate NTIS** OTS0572833
skin
rabbit 		500 無/24 hour mild NTIS** OTS0572832


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis human leukocyte 100 痠ol/L DBTEAD 19,215,1971
DNA damage mammal (species unspecified) lymphocyte 150 mmol/L PNASA6 48,686,1962


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
subcutaneous
gerbil 		lowest published toxic dose: 315 mg/kg (21 day male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct

Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands 		IJEBA6 17,1305,1979
subcutaneous
rat 		lowest published toxic dose: 315 mg/kg (21 day male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct

Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands 		IJEBA6 17,1305,1979


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
human 		lowest published toxic concentration: 75 ppm Olfaction: Other olfaction effects

Eye: Conjunctiva irritation

Lung, Thorax, or Respiration: Other changes 		JIHTAB 25,282,1943
inhalation
human 		lowest published toxic concentration: 400 mg/m3/3 minute Eye: Conjunctiva irritation

Lung, Thorax, or Respiration: Cough 		VCVGK* -,129,1984
inhalation
mammal (species unspecified) 		lowest published toxic concentration: 1,870 mg/m3/40 minute Brain and Coverings: Other degenerative changes VCVGK* -,129,1984
inhalation
mouse 		lowest published toxic concentration: 7 mg/m3 Behavioral: General anesthetic VCVGK* -,129,1984
inhalation
rat 		lethal concentration : >6,500 mg/m3/1 hour N/R NTIS** OTS0572832
inhalation
rat 		lowest published toxic concentration: 7 mg/m3 Behavioral: General anesthetic VCVGK* -,129,1984
intramuscular
mouse 		lethal dose (50 percent kill): 1 gm/kg N/R JSICAZ 21,342,1962
intraperitoneal
mouse 		lethal dose (50 percent kill): 1,352 mg/kg N/R ARZNAD 19,1254,1969
intravenous
mouse 		lethal dose (50 percent kill): 272 mg/kg N/R AIPTAK 135,330,1962
oral
rat 		lethal dose (50 percent kill): 1,400 mg/kg Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		NTIS** OTS0538617
oral
rabbit 		lowest published lethal dose: 2,200 mg/kg Behavioral: General anesthetic JIHTAB 25,199,1943
oral
rabbit 		lowest published lethal dose: 2,600 mg/kg N/R VCVGK* -,129,1984
parenteral
frog 		lowest published lethal dose: 1,914 mg/kg Cardiac: Other changes JPETAB 24,405,1925
skin
rabbit 		lowest published lethal dose: 794 mg/kg Behavioral: Somnolence (general depressed activity)

Liver: Change in gall bladder structure or function

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		NTIS** OTS0538617


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 70 mg/m3/4 hour/122 day- intermittent Liver: Other changes

Kidney, Ureter, and Bladder: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		VCVGK* -,129,1994
inhalation
rat 		lowest published toxic concentration: 30 mg/m3/4 hour/134 day- intermittent Blood: Normocytic anemia

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		VCVGK* -,129,1994
inhalation
rabbit 		lowest published toxic concentration: 1,229 ppm/6 hour/5 week- intermittent Behavioral: General anesthetic

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		JIHTAB 25,323,1943
inhalation
rabbit 		lowest published toxic concentration: 997 ppm/6 hour/11 week- intermittent Behavioral: General anesthetic

Eye: Conjunctiva irritation

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		JIHTAB 25,323,1943
inhalation
rabbit 		lowest published toxic concentration: 4,930 mg/m3/6 hour/5 week- intermittent Behavioral: General anesthetic

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		VCVGK* -,129,1994
inhalation
rabbit 		lowest published toxic concentration: 580 mg/m3/6 hour/5 week- intermittent Brain and Coverings: Other degenerative changes

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes 		VCVGK* -,129,1994
intraperitoneal
rat 		lowest published toxic dose: 4 gm/kg/10 day- intermittent Kidney, Ureter, and Bladder: Other changes in urine composition TOLED5 45,271,1989
oral
rat 		lowest published toxic dose: 3,185 mg/kg/7 day- continuous Liver: Other changes

Liver: Changes in liver weight 		APTOA6 51,217,1982
skin
rabbit 		lowest published toxic dose: 50 mL/kg/1 hour/10 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field VCVGK* -,129,1994


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 50 ppm (skin) DTLVS* TLV/BEI,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 50 ppm (200 mg/m3) DTLVS* 3,65,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 50 ppm (200 mg/m3) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 50 ppm (200 mg/m3) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 50 ppm (200 mg/m3) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 50 ppm (200 mg/m3) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 50 ppm (200 mg/m3), Skin, JAN1993
Occupational Exposure Limit - AUSTRIA MAK 50 ppm (200 mg/m3), JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 50 ppm (206 mg/m3), Skin, JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 50 ppm (200 mg/m3), JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 50 ppm (200 mg/m3), short term exposure limit 75 ppm (300 mg/m3), JAN1999
Occupational Exposure Limit - FRANCE VME 50 ppm (200 mg/m3), VLE 75 ppm (300 mg/m3), JAN1999
Occupational Exposure Limit - GERMANY MAK 50 ppm (200 mg/m3), JAN1999
Occupational Exposure Limit - HUNGARY time-weighted average 20 mg/m3, short term exposure limit 40 mg/m3, Skin, JAN1993
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 1 mg/m3, 2003
Occupational Exposure Limit - NORWAY time-weighted average 25 ppm (100 mg/m3), JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 50 ppm (200 mg/m3), JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 20 mg/m3, short term exposure limit 60 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA time-weighted average 25 ppm, JAN1993
Occupational Exposure Limit - SWEDEN NGV 50 ppm (200 mg/m3), KTV 75 ppm (300 mg/m3), JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 50 ppm (200 mg/m3), KZG- week 100 ppm (400 mg/m3),JAN1999
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 50 ppm (208 mg/m3), SEP2000
Occupational Exposure Limit - UNITED KINGDOM LTEL 50 ppm (200 mg/m3), JAN1993
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 50 ppm (skin)
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 50 ppm (skin)


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO CYCLOHEXANOL-air 10 hour time-weighted average 50 ppm (Sk) NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 21560;
Number of Industries 56;
Total Number of Facilities 6,542;
Number of Occupations 63;
Total Number of Employees Exposed 65,435
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 21560;
Number of Industries 52;
Total Number of Facilities 10,121;
Number of Occupations 66;
Total Number of Employees Exposed 112,365;
Total Number of Female Employees Exposed 41,412


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in making placticizers, dry cleaning, dyebath and textile finishing formulations
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-9206
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Alcohols III, 1402


REFERENCES:

CODEN
REFERENCE
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898-
APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DBTEAD Diabete. (Le Raincy, France) V.1-22, 1953-74. Discontinued.
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
IJEBA6 Indian Journal of Experimental Biology. (Publications & Information Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU.
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
JSICAZ Journal of Scientific and Industrial Research, Section C: Biological Sciences. (New Delhi, India) V.14-21, 1955-62. For publisher information, see IJEBA6.
JTPAE7 Journal of Toxicologic Pathology. (Nihon Dokusei Byori Gakkai, editor, 3-25-8 Nishi- shinbashi, Minato-ku, Tokyo 105, Japan) V.1- 1988
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
PNASA6 Proceedings of the National Academy of Sciences of the United States of America. (National Academy of Sciences, Printing & Pub. Office, 2101 Constitution Ave., Washington, DC 20418) V.1- 1915-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.

Used in making placticizers, dry cleaning, dyebath and textile finishing formulations

NIOSH PROFILE (ALCOHOLS), SRI, 2/77

RTECS Compound Description:
   Mutagen
   Reproductive Effector
   Human Data
   Primary Irritant

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