The Registry of Toxic Effects of Chemical Substances

Cyclohexane, methyl -

RTECS #: GV6125000

CAS #: 108-87-2

UPDATE: November 2004 MW: 98.21 MF: C7H14


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. Cyclohexylmethane
  2. Hexahydrotoluene
  3. Methylcyclohexane
  4. Methylcyclohexane (ACGIH:OSHA)
  1. Metylocykloheksan (Polish)
  2. Sextone B
  3. Toluene hexahydride
  4. Toluene, hexahydro -


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		100 µL/24 hour mild NTIS** OTS0556748
skin
rabbit 		500 µL/24 hour mild NTIS** OTS0556749


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mouse 		lethal concentration (16 percent kill): 35,000 mg/m3/2 hour N/R VCVGH* -,84,1990
inhalation
mouse 		lethal concentration (50 percent kill): 36,900 mg/m3/2 hour N/R VCVGH* -,84,1990
inhalation
mouse 		lethal concentration (84 percent kill): 47,000 mg/m3/2 hour N/R VCVGH* -,84,1990
inhalation
rat 		lowest published lethal concentration: 82 gm/m3/1 hour Behavioral: General anesthetic

Behavioral: Convulsions or effect on seizure threshold

Behavioral: Ataxia 		NTIS** OTS0556685
inhalation
rabbit 		lethal concentration (50 percent kill): 15,227 ppm/1 hour Behavioral: General anesthetic

Behavioral: Convulsions or effect on seizure threshold

Gastrointestinal: Changes in structure or function of salivary glands 		JIHTAB 25,323,1943
inhalation
rabbit 		lowest published lethal concentration: 60,000 mg/m3/70 minute Eye: Conjunctiva irritation

Behavioral: General anesthetic

Behavioral: Convulsions or effect on seizure threshold 		VCVGH* -,84,1990
oral
mouse 		lethal dose (16 percent kill): 1.28 gm/kg N/R VCVGH* -,85,1990
oral
mouse 		lethal dose (50 percent kill): 1.2 gm/kg N/R VCVGH* -,85,1990
oral
mouse 		lethal dose (84 percent kill): 3.4 gm/kg N/R VCVGH* -,85,1990
oral
rat 		lethal dose (50 percent kill): >3,200 mg/kg N/R NTIS** OTS0556685
oral
rabbit 		lowest published lethal dose: 4 gm/kg Gastrointestinal: Hypermotility, diarrhea JIHTAB 25,199,1943
skin
rabbit 		lethal dose : >86,700 mg/kg N/R JIHTAB 25,199,1943


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 11 gm/m3/6 hour/5 day- intermittent Behavioral: General anesthetic NTIS** OTS0556685
inhalation
rabbit 		lowest published toxic concentration: 10,054 ppm/6 hour/2 week- intermittent Eye: Conjunctiva irritation

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		JIHTAB 25,323,1943


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 400 ppm DTLVS* TLV/BEI,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 500 ppm (2000 mg/m3) DTLVS* 3,162,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 500 ppm (2000 mg/m3) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 500 ppm (2000 mg/m3) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 500 ppm (2000 mg/m3) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 500 ppm (2000 mg/m3) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 400 ppm (1600 mg/m3), JAN1993
Occupational Exposure Limit - BELGIUM time-weighted average 400 ppm (1610 mg/m3), JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 200 ppm (805 mg/m3), JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 400 ppm (1600 mg/m3), short term exposure limit 500 ppm (2000 mg/m3), JAN1999
Occupational Exposure Limit - FRANCE VME 400 ppm (1600 mg/m3), JAN1999
Occupational Exposure Limit - GERMANY MAK 50 ppm (200 mg/m3), JAN1999
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 400 ppm (1600 mg/m3), JAN1999
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 1600 mg/m3, 2003
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 500 ppm (2000 mg/m3), JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 500 mg/m3, MAC(short term exposure limit) 2000 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA time-weighted average 400 ppm, short term exposure limit 50 mg/m3, JAN1993
Occupational Exposure Limit - SWITZERLAND MAK- week 400 ppm (1600 mg/m3), KZG- week 800 ppm (3200 mg/m3), JAN1999
Occupational Exposure Limit - TURKEY time-weighted average 500 ppm (2000 mg/m3), JAN1993
Occupational Exposure Limit - UNITED KINGDOM LTEL 400 ppm (1600 mg/m3), short term exposure limit 500 ppm, JAN1993
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 400 ppm
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 400 ppm


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO METHYLCYCLOHEXANE-air 10 hour time-weighted average 400 ppm NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 47030;
Number of Industries 11;
Total Number of Facilities 1,733;
Number of Occupations 9;
Total Number of Employees Exposed 6,292
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 47030;
Number of Industries 12;
Total Number of Facilities 1,175;
Number of Occupations 11;
Total Number of Employees Exposed 10,076;
Total Number of Female Employees Exposed 14


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Hydrocarbons, BP 36-126 degree C, 1500


REFERENCES:

CODEN
REFERENCE
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU.
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
VCVGH* "Vrednie chemichescie veshestva, galogenproisvodnie uglevodorodov". (Hazardous substances: Galogenated hydrocarbons) Bandman A.L. et al., Chimia, 1990.

NIOSH PROFILE (ALKENES), SRI, 2/77

NIOSH PROFILE (ALKENES), SRC, 4/78

RTECS Compound Description:
   Primary Irritant

 Click Here for Additional Information about RTECS