The Registry of Toxic Effects of Chemical Substances

Cyclohexane, 1,2,3,4,5,6 - hexachloro - , alpha - isomer

RTECS #: GV3500000

CAS #: 319-84-6

UPDATE: May 2005 MW: 290.82 MF: C6H6Cl6


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. TUMORIGENIC DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. 1 - alpha,2 - alpha,3 - beta,4 - alpha,5 - beta,6 - beta - Hexachlorocyclohexane
  2. Benzene hexachloride - alpha - isomer
  3. Cyclohexane, 1,2,3,4,5,6 - hexachloro - , alpha -
  4. Cyclohexane, alpha - 1,2,3,4,5,6 - hexachloro -
  5. ENT 9,232
  6. Hexachlorcyclohexan (German)
  7. alpha - 1,2,3,4,5,6 - Hexachlorocyclohexane
  8. alpha - BHC
  1. alpha - Benzenehexachloride
  2. alpha - HCH
  3. alpha - Hexachloran
  4. alpha - Hexachlorane
  5. alpha - Hexachlorcyclohexane
  6. alpha - Hexachlorocyclohexane
  7. alpha - Isomer of benzene hexachloride
  8. alpha - Lindane


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis oral
rat 		756 mg/kg/3 week JNCIAM 54,1245,1975
unscheduled DNA synthesis oral
rat 		100 µmol/kg CRNGDP 8,1433,1987
unscheduled DNA synthesis rat liver 10 µmol/L CNREA8 42,3010,1982
morphological transform oral
rat 		2,520 mg/kg/6 week CRNGDP 9,387,1988


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 5 gm/kg/24 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors 		JNCIAM 51,1637,1973
oral
mouse 		toxic dose : 10 gm/kg/24 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors 		NAIZAM 25,635,1974
oral
mouse 		toxic dose : 12,960 mg/kg/26 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors 		CMSHAF 1,279,1972
oral
mouse 		toxic dose : 8,820 mg/kg/21 week- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors 		JJIND8 71,1307,1983
oral
mouse 		toxic dose : 5,040 mg/kg/24 week- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors 		SAIGBL 17,54,1975
oral
mouse 		toxic dose : 10,080 mg/kg/24 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors 		NAIZAM 24,1,1973
oral
rat 		lowest published toxic dose: 20 gm/kg/48 week- continuous Tumorigenic: Neoplastic by RTECS criteria

Liver: Tumors 		JNCIAM 54,801,1975
oral
rat 		toxic dose : 11,040 mg/kg/86 week- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors 		CNREA8 41,4140,1981
oral
rat 		toxic dose : 13,020 mg/kg/92 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors 		CNREA8 41,4140,1981
oral
rat 		lowest published toxic dose: 5.040 mg/kg/6 week- continuous Tumorigenic: Neoplastic by RTECS criteria

Liver: Tumors

Tumorigenic: Facilitates action of known carcinogens 		CALEDQ 163,179,2001


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
human 		lowest published lethal dose: 14 gm/kg N/R 85GYAV -,54,1971
oral
mouse 		lethal dose (50 percent kill): 78 mg/kg N/R OSDIAF 15,553,1966
oral
rat 		lethal dose (50 percent kill): 177 mg/kg N/R FATOAO 39,455,1976


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 13,104 mg/kg/26 week- continuous Liver: Other changes

Liver: Tumors

Liver: Changes in liver weight 		CMSHAF 1,279,1972
oral
mouse 		lowest published toxic dose: 6,048 mg/kg/12 week- continuous Liver: Other changes

Liver: Tumors

Liver: Changes in liver weight 		CMSHAF 1,153,1972
oral
rat 		lowest published toxic dose: 18 mg/kg/15 day- continuous Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases 		TOLED5 56,137,1991
oral
rat 		lowest published toxic dose: 36 mg/kg/30 day- continuous Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases 		TOLED5 56,137,1991
oral
rat 		lowest published toxic dose: 8,736 mg/kg/26 week- continuous Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		JPETAB 100,59,1950
oral
rat 		lowest published toxic dose: 30.2 gm/kg/72 week- continuous Liver: Tumors ENVRAL 19,460,1979


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 20,195,1979
TOXICOLOGY REVIEW
MUREAV 567,109,2004
TOXICOLOGY REVIEW
REPTED 19,209,2004


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.5 mg/m3, Skin, JAN1993
Occupational Exposure Limit - BELGIUM time-weighted average 0.5 mg/m3, Skin, JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 0.5 mg/m3, Skin, JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 0.5 mg/m3, Skin, Carcinogen, JAN1999
Occupational Exposure Limit - FRANCE VME 0.5 mg/m3, Skin, JAN1993
Occupational Exposure Limit - GERMANY MAK 0.5 mg/m3, Skin, JAN1999
Occupational Exposure Limit - HUNGARY time-weighted average 0.5 mg/m3, short term exposure limit 0.1 mg/m3, Skin, JAN1993
Occupational Exposure Limit - RUSSIA short term exposure limit 0.05 mg/m3, Skin, JAN1993
Occupational Exposure Limit - SWITZERLAND MAK- week 0.5 mg/m3, Skin, JAN1999
Occupational Exposure Limit - UNITED KINGDOM LTEL 0.5 mg/m3, short term exposure limit 1.5 mg/m3, Skin, JAN1993


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
N/R N/R N/R


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
ATSDR TOXICOLOGY PROFILE (NTIS** PB/90/171406/AS)
EPA GENETOX PROGRAM 1988, Negative: S cerevisiae-reversion
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as an agricultural chemical, pesticide, pharmaceutical and veterinary drug
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NTP 11th Report on Carcinogens,2004:Reasonably anticipated to be a human carcinogen


REFERENCES:

CODEN
REFERENCE
85GYAV "Pflanzenschutz-und Schaedlingsbekaempfungsmittel: Abriss einer Toxikologie und Therapie von Vergiftungen," 2nd ed., Klimmer, O.R., Hattingen, Fed. Rep. Ger., Hundt-Verlag, 1971
CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1975-
CMSHAF Chemosphere. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1972-
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941-
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1967-
FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939-
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
JJIND8 JNCI, Journal of the National Cancer Institute. (Washington, DC) V.61-79, 1978-87. For publisher information, see JNCIEQ.
JNCIAM Journal of the National Cancer Institute. (Washington, DC) V.1-60, 1940-78. For publisher information, see JJIND8.
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NAIZAM Nara Igaku Zasshi. Journal of the Nara Medical Association. (Nara Igakkai, c/o Narakenritsu Ika Daigaku, Shijo-cho, Kashihara, Nara-ken, Japan) V.1- 1950-
OSDIAF Osaka Shiritsu Daigaku Igaku Zasshi. Journal of the Osaka City Medical Center. (Osaka, Japan) V.4-23, 1955-74. For publisher information, see OIGZDE.
REPTED Reproductive Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987-
SAIGBL Sangyo Igaku. Japanese Journal of Industrial Health. (Nippon Sangyo Eisei Igakkai, Kosu Eisei Bldg., 1-29-8, Shinjuku, Shinjuku-ku, Tokyo 160, Japan) V.1- 1959-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-

Used as an agricultural chemical, pesticide, pharmaceutical and veterinary drug

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Mutagen
   Human Data

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