The Registry of Toxic Effects of Chemical Substances

Cyclohexane

RTECS #: GU6300000

CAS #: 110-82-7

UPDATE: November 2004 MW: 84.18 MF: C6H12


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. Benzene, hexahydro -
  2. Cicloesano (Italian)
  3. Cyclohexaan (Dutch)
  4. Cyclohexan (German)
  5. Cyclohexane (ACGIH:OSHA)
  1. Cykloheksan (Polish)
  2. Hexahydrobenzene
  3. Hexamethylene
  4. Hexanaphthene
  5. RCRA waste number U056


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
skin
rabbit 		1,548 mg/2 day- intermittent N/R JIHTAB 25,199,1943


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
DNA adduct Escherichia coli 10 µmol/L MUREAV 89,95,1981


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
cat 		lowest published toxic concentration: 62,500 mg/m3/15 minute Behavioral: Convulsions or effect on seizure threshold

Vascular: BP lowering not characterized in autonomic section 		VCVGH* -,82,1990
inhalation
mammal (species unspecified) 		lethal concentration (50 percent kill): 70 gm/m3 N/R GTPZAB 32(10),25,1988
inhalation
mouse 		lowest published lethal concentration: 70 gm/m3/2 hour N/R 85GMAT -,41,1982
inhalation
mouse 		lethal concentration (50 percent kill): 70,000 mg/m3/2 hour N/R VCVGH* -,82,1990
inhalation
rabbit 		lowest published lethal concentration: 89,600 mg/m3/1 hour Behavioral: General anesthetic

Behavioral: Tremor

Behavioral: Muscle contraction or spasticity 		JIHTAB 25,323,1943
inhalation
rabbit 		lowest published lethal concentration: 89,500 mg/m3/1 hour Behavioral: General anesthetic VCVGH* -,82,1990
oral
mouse 		lethal dose (50 percent kill): 813 mg/kg N/R NPIRI* 1,17,1974
oral
rat 		lethal dose (50 percent kill): 12,705 mg/kg N/R TXAPA9 19,699,1971
oral
rabbit 		lowest published lethal dose: 5,500 mg/kg Gastrointestinal: Hypermotility, diarrhea JIHTAB 25,199,1943
skin
rabbit 		lethal dose : >180 gm/kg N/R JIHTAB 25,199,1943


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mouse 		lowest published toxic concentration: 2,000 ppm/90 day- intermittent Behavioral: Somnolence (general depressed activity)

Behavioral: Change in motor activity (specific assay) 		TOXID9 42,255,1998
inhalation
rat 		lowest published toxic concentration: 300 ppm/6 hour/2 week- intermittent Brain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases 		TOLED5 7,17,1980
inhalation
rat 		lowest published toxic concentration: 2,000 ppm/13 week- intermittent Behavioral: Somnolence (general depressed activity) TOXID9 42,35,1998
inhalation
rabbit 		lowest published toxic concentration: 7,444 ppm/6 hour/2 week- intermittent Autonomic Nervous System: Other (direct) parasympathomimetic

Gastrointestinal: Hypermotility, diarrhea

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		JIHTAB 25,323,1943
inhalation
rabbit 		lowest published toxic concentration: 9,220 ppm/6 hour/5 week- intermittent Autonomic Nervous System: Other (direct) parasympathomimetic

Behavioral: Tremor

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		JIHTAB 25,323,1943
intraperitoneal
rat 		lowest published toxic dose: 15 gm/kg/2 week- intermittent Kidney, Ureter, and Bladder: Other changes in urine composition TOLED5 45,271,1989


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 100 ppm DTLVS* TLV/BEI,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 300 ppm (1050 mg/m3) DTLVS* 3,65,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 300 ppm (1050 mg/m3) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 300 ppm (1050 mg/m3) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 300 ppm (1050 mg/m3) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 300 ppm (1050 mg/m3) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 300 ppm (1050 mg/m3), JAN1993
Occupational Exposure Limit - AUSTRIA MAK 300 ppm (1050 mg/m3), JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 300 ppm (1030 mg/m3), JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 200 ppm (690 mg/m3), JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 300 ppm (1050 mg/m3), short term exposure limit 375 ppm (1315 mg/m3), JAN1999
Occupational Exposure Limit - FRANCE VME 300 ppm (1050 mg/m3), VLE 375 ppm (1300 mg/m3), JAN1999
Occupational Exposure Limit - GERMANY MAK 300 ppm (1050 mg/m3), JAN1999
Occupational Exposure Limit - HUNGARY time-weighted average 500 mg/m3, short term exposure limit 1000 mg/m3, JAN1993
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 875 mg/m3, 2003
Occupational Exposure Limit - NORWAY time-weighted average 150 ppm (525 mg/m3), JAN1999
Occupational Exposure Limit - POLAND MAC(time-weighted average) 300 mg/m3, MAC(short term exposure limit) 1000 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA time-weighted average 150 ppm, short term exposure limit 80 mg/m3, JAN1993
Occupational Exposure Limit - SWEDEN NGV 300 ppm (1000 mg/m3), KTV 370 ppm (1300 mg/m3), JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 300 ppm (1050 mg/m3), KZG- week 600 ppm (2100 mg/m3), JAN1999
Occupational Exposure Limit - TURKEY time-weighted average 300 ppm (1050 mg/m3), JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 100 ppm (350 mg/m3), short term exposure limit 300 ppm, SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 100 ppm
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 100 ppm


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO CYCLOHEXANE-air 10 hour time-weighted average 300 ppm NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 21190;
Number of Industries 117;
Total Number of Facilities 14,841;
Number of Occupations 74;
Total Number of Employees Exposed 125,761
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 21190;
Number of Industries 37;
Total Number of Facilities 2,260;
Number of Occupations 54;
Total Number of Employees Exposed 55,077;
Total Number of Female Employees Exposed 14,873


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Negative: Cell transform.-SA7/SHE; Histidine reversion-Ames test
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a solvent
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Hydrocarbons, BP 36-126 degree C, 1500


REFERENCES:

CODEN
REFERENCE
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU.
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NPIRI* Raw Material Data Handbook, Vol.1: Organic Solvents, 1974. (National Assoc. of Printing Ink Research Institute, Francis McDonald Sinclair Memorial Laboratory, Lehigh Univ., Bethlehem, PA 18015)
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
VCVGH* "Vrednie chemichescie veshestva, galogenproisvodnie uglevodorodov". (Hazardous substances: Galogenated hydrocarbons) Bandman A.L. et al., Chimia, 1990.

Used as a solvent

Top 50 chemical production: 2.21 billions lbs in 1992, 2.31 billions in 1991

NIOSH PROFILE (PETROLEUM REFINING), FIRL, 4/78

RTECS Compound Description:
   Mutagen
   Primary Irritant

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