The Registry of Toxic Effects of Chemical Substances

Cyanogen chloride

RTECS #: GT2275000

CAS #: 506-77-4

UPDATE: November 2004 MW: 61.47 MF: CClN


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. ACUTE TOXICITY DATA:
  3. REVIEWS:
  4. STANDARDS AND REGULATIONS:
  5. NIOSH DOCUMENTATION AND SURVEILLANCE:
  6. STATUS IN FEDERAL AGENCIES:
  7. REFERENCES:

SYNONYMS:

  1. Chlorcyan
  2. Chlorine cyanide
  3. Chlorocyan
  4. Chlorocyanide
  1. Chlorocyanogen
  2. Chlorure de cyanogene (French)
  3. Cyanogen chloride (ACGIH)
  4. RCRA waste number P033


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
human 		lowest published toxic concentration: 10 mg/m3 Eye: Lacrimation

Eye: Conjunctiva irritation

Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion 		WHOTAC -,31,1970
inhalation
man 		lowest published toxic concentration: 2 gm/m3 Skin: After topical application: Primary irritation NTIS** PB158-508
oral
cat 		lethal dose (50 percent kill): 6 mg/kg N/R NTIS** PB158-508
subcutaneous
dog 		lowest published lethal dose: 5 mg/kg N/R HBAMAK 4,1341,1935
subcutaneous
pigeon 		lowest published lethal dose: 8,700 µg/kg N/R HBAMAK 4,1341,1935
subcutaneous
rabbit 		lowest published lethal dose: 20 mg/kg N/R HBAMAK 4,1341,1935
unreported route
dog 		lethal dose (50 percent kill): 3,300 µg/kg N/R NTIS** PB158-508
unreported route
domestic animal 		lethal dose (50 percent kill): 2,970 µg/kg N/R NTIS** PB158-508
unreported route
rabbit 		lethal dose (50 percent kill): 3,150 µg/kg N/R NTIS** PB158-508


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value ceiling concentration 0.3 ppm DTLVS* TLV/BEI,2003
TOXICOLOGY REVIEW
MUREAV 539,77,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.3 ppm (0.6 mg/m3), JAN1993
Occupational Exposure Limit - BELGIUM short term exposure limit 0.3 ppm (0.75 mg/m3), JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 0.1 ppm (0.3 mg/m3), JAN1999
Occupational Exposure Limit - FINLAND short term exposure limit 0.1 ppm (0.3 mg/m3), Skin, JAN1999
Occupational Exposure Limit - FRANCE VLE 0.3 ppm (0.6 mg/m3), JAN1999
Occupational Exposure Limit - GERMANY No MAK Established, JAN1999
Occupational Exposure Limit - NORWAY time-weighted average 0.25 ppm (0.6 mg/m3), JAN1999
Occupational Exposure Limit - THE NETHERLANDS MAC- continuous 0.6 mg/m3, 2003
Occupational Exposure Limit - SWITZERLAND MAK- week 0.3 ppm (0.8 mg/m3), JAN1999
Occupational Exposure Limit - UNITED KINGDOM short term exposure limit 0.3 ppm (0.77 mg/m3), SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

ceiling concentration 0.3 ppm
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
ceiling concentration 0.3 ppm


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO CYANOGEN CHLORIDE-air ceiling concentration 0.3 ppm NIOSH* DHHS #95-121,1995
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 84337;
Number of Industries 1;
Total Number of Facilities 34;
Number of Occupations 1;
Total Number of Employees Exposed 134
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 84337;
Number of Industries 1;
Total Number of Facilities 4;
Number of Occupations 16;
Total Number of Employees Exposed 1,391


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
ATSDR TOXICOLOGY PROFILE (NTIS** PB/98/101207/AS)
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-9033
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NTP Carcinogenesis studies; selected, October 2000


REFERENCES:

CODEN
REFERENCE
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig, Ger. Dem. Rep.)
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
WHOTAC World Health Organization, Technical Report Series. (WHO, 1211 Geneva, 27, Switzerland) No.1- 1950-

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Human Data

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