The Registry of Toxic Effects of Chemical Substances

Cyanamide, calcium salt (1:1)

RTECS #: GS6000000

CAS #: 156-62-7

UPDATE: November 2004 MW: 80.11 MF: CN2•Ca


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. TUMORIGENIC DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. Alzodef
  2. CCC
  3. CY - L 500
  4. Calcium carbimide
  5. Calcium cyanamid
  6. Calcium cyanamide
  7. Calcium cyanamide (ACGIH)
  8. Cyanamid granular
  1. Cyanamide calcique (French)
  2. Dormex
  3. Lime - nitrogen
  4. NCI - C02937
  5. Nitrogen lime
  6. Nitrolim
  7. Nitrolime
  8. USAF CY - 2


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
mutation in microorganisms Salmonella typhimurium 1 mg/plate (+enzymatic activation step) ENMUDM 5(Suppl 1),3,1983


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 170 gm/kg/2 year- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Vascular: Tumors 		NCITR* NCI-TR-163,1979


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lethal concentration (50 percent kill): >150 mg/m3/4 hour N/R 85JFAN A053,1984
inhalation
rat 		lowest published toxic concentration: 3,000 mg/m3/20 minute Behavioral: Somnolence (general depressed activity) VCVN1* -,346,1988
intraperitoneal
mouse 		lethal dose (50 percent kill): 100 mg/kg N/R NTIS** AD277-689
intravenous
mouse 		lethal dose (50 percent kill): 282 mg/kg N/R NIIRDN 6,304,1982
intravenous
rat 		lethal dose (50 percent kill): 125 mg/kg N/R NIIRDN 6,304,1982
oral
guinea pig 		lethal dose (50 percent kill): 220 mg/kg Behavioral: Irritability

Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea 		VCVN1* -,346,1988
oral
human 		lowest published lethal dose: 571 mg/kg N/R 34ZIAG -,149,1969
oral
mouse 		lethal dose (50 percent kill): 334 mg/kg N/R NIIRDN 6,304,1982
oral
mouse 		lethal dose (50 percent kill): 334 mg/kg Behavioral: Irritability

Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea 		VCVN1* -,346,1988
oral
rat 		lethal dose (50 percent kill): 158 mg/kg N/R NIIRDN 6,304,1982
oral
rat 		lethal dose (50 percent kill): 250 mg/kg Behavioral: Irritability

Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea 		VCVN1* -,346,1988
oral
rabbit 		lethal dose (50 percent kill): 1,400 mg/kg N/R PCOC** -,174,1966
oral
rabbit 		lethal dose (50 percent kill): 350 mg/kg Behavioral: Irritability

Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea 		VCVN1* -,346,1988
skin
rabbit 		lethal dose (50 percent kill): 590 mg/kg N/R 37ASAA 7,291,1979
unreported route
human 		lowest published lethal dose: 571.4 mg/kg N/R VCVN1* -,346,1988
unreported route
rat 		lethal dose (50 percent kill): 1 gm/kg N/R GUCHAZ 6,73,1973


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 250 mg/kg/10 day- intermittent Behavioral: Tremor

Lung, Thorax, or Respiration: Dyspnea

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) 		VCVN1* -,347,1988


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.5 mg/m3 DTLVS* TLV/BEI,2003
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not Classifiable as a Human Carcinogen DTLVS* TLV/BEI,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Cancelled RBREV* -,299,1998
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.5 mg/m3, JAN1993
Occupational Exposure Limit - AUSTRIA MAK 0.5 mg/m3, Skin, JAN1999
Occupational Exposure Limit - DENMARK time-weighted average 0.5 mg/m3, JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 0.5 mg/m3, short term exposure limit 1.5 mg/m3, JAN1999
Occupational Exposure Limit - FRANCE VME 0.5 mg/m3, JAN1999
Occupational Exposure Limit - GERMANY MAK 1 mg/m3 (total dust), Skin, JAN1993
Occupational Exposure Limit - NORWAY time-weighted average 0.5 mg/m3, JAN1999
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 0.5 mg/m3, 2003
Occupational Exposure Limit - SWITZERLAND MAK- week 0.5 mg/m3, Skin, JAN1999
Occupational Exposure Limit - UNITED KINGDOM LTEL 0.5 mg/m3, short term exposure limit 1 mg/m3, JAN1993
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Not Classifiable as a Human Carcinogen
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Not Classifiable as a Human Carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO CALCIUM CYANAMIDE-air 10 hour time-weighted average 0.5 mg/m3 NIOSH* DHHS #95-121,1995
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 15730;
Number of Industries 2;
Total Number of Facilities 287;
Number of Occupations 2;
Total Number of Employees Exposed 12,607
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 15730;
Number of Industries 2;
Total Number of Facilities 249;
Number of Occupations 3;
Total Number of Employees Exposed 4,390


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used to manufacture CALCIUM CYANIDE, DICYANDIAMIDE and used in desulphurization of steels
NCI Carcinogenesis Bioassay (feed);no evidence:mouse,rat NCITR* NCI-TR-163,1979


REFERENCES:

CODEN
REFERENCE
34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969
37ASAA "Kirk-Othmer Encyclopedia of Chemical Technology," 3rd ed., Grayson, M., and D. Eckroth, eds., New York, John Wiley & Sons, Inc., 1978
85JFAN "Agrochemicals Handbook," with updates, Hartley, D., and H. Kidd, eds., Nottingham, Royal Soc. of Chemistry, 1983-86
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG.
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
GUCHAZ Guide to the Chemicals Used in Crop Protection. (Information Canada, 171 Slater St., Ottawa, Ont., Canada)
NCITR* National Cancer Institute Carcinogenesis Technical Report Series. (Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan)
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
PCOC** Pesticide Chemicals Official Compendium, Association of the American Pesticide Control Officials, Inc., 1966. (Topeka, KS)
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
VCVN1* "Vrednie chemichescie veshestva. Neorganicheskie soedinenia elementov I-IV groopp" (Hazardous substances. Inornanic substances containing I-IV group elements), Filov V.A., Chimia, 1988.

Used to manufacture CALCIUM CYANIDE, DICYANDIAMIDE and used in desulphurization of steels

NIOSH PROFILE (CALCIUM CYANAMIDE), SRC, 3/81

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Mutagen
   Human Data

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