The Registry of Toxic Effects of Chemical Substances

Crotonic acid, 3 - hydroxy - , methyl ester, dimethyl phosphate

RTECS #: GQ5250000

CAS #: 7786-34-7

UPDATE: November 2004 MW: 224.17 MF: C7H13O6P


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. (2 - Methoxycarbonyl - 1 - methyl - vinyl) - dimethyl - fosfaat (Dutch)
  2. (2 - Methoxycarbonyl - 1 - methyl - vinyl) - dimethyl - phosphat (German)
  3. (2 - Metossicarbonil - 1 - metil - vinil) - dimetil - fosfato (Italian)
  4. 1 - Methoxycarbonyl - 1 - propen - 2 - yl dimethyl phosphate
  5. 2 - Butenoic acid, 3 - ( (dimethoxyphosphinyl) oxy) - , methyl ester (9CI)
  6. 2 - Carbomethoxy - 1 - methyl - vinyl dimethyl phosphare
  7. 2 - Carbomethoxy - 1 - methylvinyl dimethyl phosphate
  8. 2 - Carbomethoxy - 1 - propen - 2 - yl dimethyl phosphate
  9. 2 - Methoxycarbonyl - 1 - methylvinyl dimethyl phosphate
  10. 3 - ( (Dimethoxyphosphinyl) oxy) - 2 - butenoic acid methyl ester
  11. 3 - Hydroxycrotonic acid methyl ester dimethyl phosphate
  12. CMDP
  13. Dimethyl (1 - methoxycarboxypropen - 2 - yl) phosphate
  14. Dimethyl 2 - methoxycarbonyl - 1 - methylvinyl phosphate
  15. Dimethyl methoxycarbonylpropenyl phosphate
  16. Dimethyl - 1 - carbomethoxy - 1 - propen - 2 - yl phosphate
  17. ENT 22,374
  1. Fosdrin
  2. Gesfid
  3. Meniphos
  4. Methyl 3 - (dimethoxyphosphinyloxy) crotonate
  5. Mevinfos (Dutch)
  6. Mevinphos
  7. Mevinphos (ACGIH:OSHA)
  8. O,O - Dimethyl O - (1 - methyl - 2 - carboxyvinyl) phosphate
  9. O,O - Dimethyl - O - (2 - carbomethoxy - 1 - methylvinyl) phosphate
  10. O,O - Dimethyl - O - 2 - methoxycarbonyl - 1 - methyl - vinyl - phosphat (German)
  11. PD 5 (pesticide)
  12. Phosdrin (OSHA)
  13. Phosphate de dimethyle et de 2 - methoxycarbonyl - 1 methylvinyle (French)
  14. Phosphoric acid, (1 - methoxycarboxypropen - 2 - yl) dimethyl ester
  15. Phosphoric acid, dimethyl ester, ester with methyl 3 - hydroxycrotonate
  16. alpha - 2 - Carbomethoxy - 1 - methylvinyl dimethyl phosphate


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
mutation in microorganisms Salmonella typhimurium 2,500 µg/plate (+enzymatic activation step) CHYCDW 20,12,1986
sister chromatid exchange human lymphocyte 2 mg/L MUREAV 102,89,1982


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lethal concentration (50 percent kill): 14 ppm/1 hour Behavioral: Tremor

Lung, Thorax, or Respiration: Acute pulmonary edema

Gastrointestinal: Changes in structure or function of salivary glands 		AMIHBC 9,45,1954
intraperitoneal
gerbil 		lethal dose (50 percent kill): 450 µg/kg N/R TXAPA9 36,195,1976
intraperitoneal
mouse 		lethal dose (50 percent kill): 2 mg/kg N/R CJBPAZ 39,1790,1961
intraperitoneal
rat 		lethal dose (50 percent kill): 800 µg/kg N/R APCRAW 4,117,1961
intravenous
mouse 		lethal dose (50 percent kill): 680 µg/kg N/R JPPMAB 19,612,1967
oral
wild bird 		lethal dose (50 percent kill): 1,400 µg/kg N/R JTCEEM 6(3),175,1986
oral
duck 		lethal dose (50 percent kill): 4,600 µg/kg N/R DOEAAH 35,25,1979
oral
man 		lowest published toxic dose: 700 µg/kg/28 day- intermittent Peripheral Nerve and Sensation: Recording from peripheral motor nerve TXAPA9 42,351,1977
oral
mouse 		lethal dose (50 percent kill): 4 mg/kg Gastrointestinal: Changes in structure or function of salivary glands

Behavioral: Tremor

Lung, Thorax, or Respiration: Respiratory depression 		AMIHBC 9,45,1954
oral
pigeon 		lethal dose (50 percent kill): 4,210 µg/kg N/R ASTTA8 (680),157,1979
oral
quail 		lethal dose (50 percent kill): 23,700 µg/kg N/R ASTTA8 (680),157,1979
oral
rat 		lethal dose (50 percent kill): 3 mg/kg N/R DOEAAH 35,25,1979
subcutaneous
mouse 		lethal dose (50 percent kill): 1,180 µg/kg N/R JPPMAB 19,612,1967
subcutaneous
rat 		lethal dose (50 percent kill): 940 µg/kg N/R FOLMA8 24(4),23,1982
skin
duck 		lethal dose (50 percent kill): 11 mg/kg N/R TXAPA9 47,451,1979
skin
mouse 		lethal dose (50 percent kill): 12 mg/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase JTEHD6 9,491,1982
skin
rat 		lethal dose (50 percent kill): 4,200 µg/kg Behavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold

Behavioral: Excitement 		TXAPA9 2,88,1960
skin
rabbit 		lethal dose (50 percent kill): 4,700 µg/kg N/R GUCHAZ 6,353,1973


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
human 		lowest published toxic dose: 700 µg/kg/28 day- intermittent Peripheral Nerve and Sensation: Recording from peripheral motor nerve

Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		HBPTO* 2,1069,2001
oral
rat 		lowest published toxic dose: 5,400 mg/kg/90 day- continuous Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase CHYCDW 20,12,1986
oral
rat 		lowest published toxic dose: 150 mg/kg/60 day- continuous Gastrointestinal: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		AMIHBC 9,45,1954


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.01 mg/m3 (skin) ( intermittent,V) DTLVS* TLV/BEI,2003
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not Classifiable as a Human Carcinogen DTLVS* TLV/BEI,2003
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value short term exposure limit 0.27 mg/m3 (skin) DTLVS* TLV/BEI,2002
TOXICOLOGY REVIEW
AQMOAC #73-19,1973
TOXICOLOGY REVIEW
RREVAH 46,1,1973
TOXICOLOGY REVIEW
DTTIAF 80,485,1973
TOXICOLOGY REVIEW
RREVAH 63,1,1976


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: RED Completed RBREV* -,134,1998
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 0.1 mg/m3 (skin) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 0.1 mg/m3 (skin) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 0.1 mg/m3 (skin) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 0.1 mg/m3 (skin) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - ARAB Republic of Egypt time-weighted average 0.01 ppm (0.1 mg/m3), Skin, JAN1993
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.01 ppm (0.1 mg/m3), short term exposure limit 0.03 ppm, Skin, JAN1993
Occupational Exposure Limit - AUSTRIA MAK 0.01 ppm (0.1 mg/m3), Skin, JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 0.01 ppm (0.09 mg/m3), short term exposure limit 0.03 ppm, Skin, JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 0.01 ppm (0.1 mg/m3), Skin, JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 0.001 ppm, JAN1999
Occupational Exposure Limit - FRANCE VME 0.01 ppm (0.1 mg/m3), Skin, JAN1999
Occupational Exposure Limit - GERMANY MAK 0.01 ppm (0.1 mg/m3), Skin, JAN1999
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 0.1 mg/m3, Skin, 2003
Occupational Exposure Limit - NORWAY time-weighted average 25 ppm (125 mg/m3), JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 0.1 mg/m3, Skin, JAN1993
Occupational Exposure Limit - SWITZERLAND MAK- week 0.01 ppm (0.1 mg/m3), Skin, JAN1999
Occupational Exposure Limit - THAILAND time-weighted average 0.1 mg/m3, JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 0.01 ppm (0.09 mg/m3), short term exposure limit 0.03 ppm, SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

short term exposure limit 0.27 mg/m3 (skin)
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
short term exposure limit 0.27 mg/m3 (skin)


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO PHOSDRIN-air 10 hour time-weighted average 0.01 ppm;
short term exposure limit 0.03 ppm (Sk) 		NIOSH* DHHS #92-100,1992


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Organophosphorus pesticides, 5600


REFERENCES:

CODEN
REFERENCE
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine. (Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
APCRAW Advances in Pest Control Research. (New York, NY) V.1-18, 1957-68.
AQMOAC Air Quality Monographs. (Washington, DC) No.69-1 - No.75-25, 1969-75(?). Discontinued.
ASTTA8 ASTM Special Technical Publication. (American Soc. for Testing Materials, 1916 Race St., Philadelphia, PA 19103) No.1- 1911-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CHYCDW Zhonghua Yufangyixue Zazhi. Chinese Journal of Preventive Medicine. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) Beginning history not known.
CJBPAZ Canadian Journal of Biochemistry and Physiology. (Ottawa, Ont., Canada) V.32-41, 1954-63. For publisher information, see CJBIAE.
DOEAAH Down to Earth. (Dow Chemical USA, Agricultural Products Dept., Midland, MI 48640) V.1- 1945-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
DTTIAF Deutsche Tieraerztliche Wochenschrift. (Hanover, Fed. Rep. Ger.) V.1-77, 1893-1970.
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
FOLMA8 Folia Medica (Plovdiv). (Higher Medical Institute I.P. Pavlov, Plovdiv, Bulgaria) V.1- 1959-
GUCHAZ Guide to the Chemicals Used in Crop Protection. (Information Canada, 171 Slater St., Ottawa, Ont., Canada)
HBPTO* Handbook of pesticide toxicology. Robert Krieger ed, Academic press, 2001
JPPMAB Journal of Pharmacy and Pharmacology. (Pharmaceutical Soc. of Great Britain, 1 Lambeth High St., London SEI 7JN, UK) V.1- 1949-
JTCEEM Journal de Toxicologie Clinique et Experimentale. (SPPIF, B.P.22, F-41353 Vineuil, France) V.5- 1985-
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
RREVAH Residue Reviews. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1962-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-

RTECS Compound Description:
   Agricultural Chemical
   Mutagen
   Human Data

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