The Registry of Toxic Effects of Chemical Substances

Crotonic acid

RTECS #: GQ2800000

CAS #: 3724-65-0

UPDATE: January 1997 MW: 86.10 MF: C4H6O2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. ACUTE TOXICITY DATA:
  4. NIOSH DOCUMENTATION AND SURVEILLANCE:
  5. STATUS IN FEDERAL AGENCIES:
  6. REFERENCES:

SYNONYMS:

  1. Acrylic acid, 3 - methyl -
  2. alpha - Butenoic acid
  3. 2 - Butenoic acid (9CI)
  4. Kyselina krotonova (Czech)
  1. beta - Methylacrylic acid
  2. 3 - Methylacrylic acid
  3. alpha - Crotonic acid


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
skin
rabbit 		10 mg/24 hour open irritation test N/R JIHTAB 26,269,1944


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lethal dose (50 percent kill): 25 mg/kg N/R 38MKAJ 2C,4953,1982
oral
mouse 		lethal dose (50 percent kill): 4,800 mg/kg Tumorigenic: Active as anti-cancer agent BIJOAK 34,1196,1940
oral
rat 		lethal dose (50 percent kill): 1 gm/kg N/R JIHTAB 26,269,1944
subcutaneous
mouse 		lethal dose (50 percent kill): 3,590 mg/kg N/R JPPMAB 21,85,1969
skin
guinea pig 		lethal dose (50 percent kill): 200 mg/kg N/R 38MKAJ 2C,4953,1982
skin
rabbit 		lethal dose (50 percent kill): 600 mg/kg N/R 85JCAE -,309,1986


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 84287;
Number of Industries 7;
Total Number of Facilities 234;
Number of Occupations 9;
Total Number of Employees Exposed 2,460
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 84287;
Number of Industries 6;
Total Number of Facilities 303;
Number of Occupations 7;
Total Number of Employees Exposed 5,343;
Total Number of Female Employees Exposed 209


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY


REFERENCES:

CODEN
REFERENCE
38MKAJ "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton, G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82. Vol. 3 originally pub. in 1979; pub. as 2nd rev. ed. in 1985.
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
BIJOAK Biochemical Journal. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1906-
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU.
JPPMAB Journal of Pharmacy and Pharmacology. (Pharmaceutical Soc. of Great Britain, 1 Lambeth High St., London SEI 7JN, UK) V.1- 1949-

RTECS Compound Description:
   Primary Irritant

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