The Registry of Toxic Effects of Chemical Substances

o - Cresol, 4,6 - dinitro -

RTECS #: GO9625000

CAS #: 534-52-1

UPDATE: November 2004 MW: 198.15 MF: C7H6N2O5


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. NIOSH DOCUMENTATION AND SURVEILLANCE:
  10. STATUS IN FEDERAL AGENCIES:
  11. REFERENCES:

SYNONYMS:

  1. 2,4 - Dinitro - 6 - methylphenol
  2. 2,4 - Dinitro - o - cresol
  3. 2 - Methyl - 4,6 - dinitrophenol
  4. 3,5 - Dinitro - 2 - hydroxytoluene
  5. 4,6 - Dinitro - o - cresol
  6. 4,6 - Dinitro - o - cresolo (Italian)
  7. 4,6 - Dinitro - o - kresol (Czech)
  8. 4,6 - Dinitrocresol
  9. 4,6 - Dinitrokresol (Dutch)
  10. Antinonin
  11. Antinonnin
  12. Arborol
  13. C.I. 10310
  14. Capsine
  15. Chemsect DNOC
  16. DNOC
  17. DNOK (Czech)
  18. Degrassan
  19. Dekrysil
  20. Detal
  21. Detol
  22. Dinitro - o - cresol
  23. Dinitro - o - cresol (ACGIH:OSHA)
  24. Dinitrocresol
  25. Dinitrodendtroxal
  26. Dinitrol
  27. Dinitromethyl cyclohexyltrienol
  28. Dinoc
  29. Dinurania
  30. Ditrosol
  31. Dwunitro - O - krezol (Polish)
  1. ENT 154
  2. Effusan
  3. Effusan 3436
  4. Elgetol
  5. Elgetol 30
  6. Elipol
  7. Extrar
  8. Hedolit
  9. Hedolite
  10. K III
  11. K IV
  12. Kresonite - E
  13. Krezotol 50
  14. LE dinitrocresol - 4,6 (French)
  15. Lipan
  16. Neudorff DN 50
  17. Nitrador
  18. Nitrofan
  19. Oranz viktoria (Czech)
  20. Phenol, 2 - methyl - 4,6 - dinitro - (9CI)
  21. Prokarbol
  22. RCRA waste number P047
  23. Rafex
  24. Rafex 35
  25. Raphatox
  26. Sandolin
  27. Sandolin A
  28. Selinon
  29. Sinox
  30. Winterwash
  31. Zahlreiche bezeichnungen (German)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		20 mg/24 hour moderate 85JCAE -,678,1986
skin
rabbit 		105 mg/9 day- intermittent mild JIHTAB 30,10,1948


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis oral
rat 		15 mg/kg MUREAV 321,219,1994
DNA repair other microorganisms 10 mg/plate BIZNAT 95,463,1976
mutation in microorganisms Salmonella typhimurium 100 µg/plate (+enzymatic activation step) STBIBN 117,99,1987
mutation in microorganisms Salmonella typhimurium 1 µmol/plate (-enzymatic activation step) AIDZAC 10,305,1982
sex chromosome loss and nondisjunction oral
Drosophila melanogaster 		250 µmol/L ATSUDG 4,59,1980


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 75 mg/kg (5 day male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) JTSCDR 24,350,1999


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
cat 		lowest published lethal concentration: 40 mg/m3/4 hour Behavioral: Somnolence (general depressed activity)

Behavioral: Muscle weakness

Lung, Thorax, or Respiration: Dyspnea 		HYSAAV 30(1-3),197,1965
inhalation
human 		lowest published toxic concentration: 1 mg/m3 Brain and Coverings: Recordings from specific areas of CNS

Cardiac: Other changes

Gastrointestinal: Other changes 		HYSAAV 30(1-3),197,1965
inhalation
mammal (species unspecified) 		lethal concentration (30 percent kill): 100 mg/m3 N/R GTPZAB 9(4),56,1965
intraperitoneal
guinea pig 		lethal dose (50 percent kill): 22,500 µg/kg N/R JPPMAB 6,619,1954
intraperitoneal
mouse 		lethal dose (50 percent kill): 19 mg/kg N/R BCPCA6 18,1389,1969
intraperitoneal
rat 		lowest published lethal dose: 28 mg/kg N/R TXAPA9 1,156,1959
intraperitoneal
rabbit 		lethal dose (50 percent kill): 23,500 µg/kg N/R JPPMAB 6,619,1954
intravenous
dog 		lowest published lethal dose: 15 mg/kg N/R AIPTAK 50,20,1935
intravenous
pigeon 		lowest published lethal dose: 7 mg/kg Gastrointestinal: Nausea or vomiting

Lung, Thorax, or Respiration: Dyspnea 		AIPTAK 50,20,1935
oral
cat 		lethal dose (50 percent kill): 50 mg/kg N/R GTPZAB 9(4),56,1965
oral
duck 		lethal dose (50 percent kill): 383,000 mg/kg N/R HBPTO* 2,1229,2001
oral
domestic animal 		lethal dose (50 percent kill): 100 mg/kg N/R 85DPAN -,-,1971/1976
oral
guinea pig 		lethal dose (50 percent kill): 24,600 µg/kg N/R GISAAA 41(6),12,1976
oral
man 		lowest published toxic dose: 7,500 µg/kg/7 day Behavioral: Somnolence (general depressed activity)

Behavioral: Headache 		CMEP** -,1,1956
oral
mouse 		lethal dose (50 percent kill): 21 mg/kg N/R AMRL** TR-72-62,1972
oral
quail 		lethal dose (50 percent kill): 1,040,000 mg/kg N/R HBPTO* 2,1229,2001
oral
rat 		lethal dose (50 percent kill): 7 mg/kg N/R DEVEAA 26,69,1972
oral
rat 		lethal dose (50 percent kill): 40 mg/kg Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation) 		FATOAO 47,90,1984
oral
rabbit 		lethal dose (50 percent kill): 24,600 µg/kg N/R GISAAA 41(6),12,1976
subcutaneous
rat 		lethal dose (50 percent kill): 25,600 µg/kg N/R JPPMAB 4,1062,1952
skin
child 		lowest published lethal dose: 500 mg/kg Behavioral: Coma

Behavioral: Headache

Gastrointestinal: Nausea or vomiting 		SMEZA5 17(1),52,1974
skin
guinea pig 		lowest published lethal dose: 500 mg/kg N/R JIHTAB 30,10,1948
skin
rat 		lethal dose (50 percent kill): 200 mg/kg N/R WRPCA2 9,119,1970
skin
rabbit 		lethal dose (50 percent kill): 1 gm/kg N/R GTPZAB 9(4),56,1965
unreported route
man 		lowest published lethal dose: 29 mg/kg N/R 85DCAI 2,73,1970
unreported route
mouse 		lethal dose (50 percent kill): 40 mg/kg N/R TGANAK 16(1),45,1982
unreported route
rat 		lethal dose (50 percent kill): 85 mg/kg N/R GTPZAB 26(6),21,1982


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
cat 		lowest published toxic concentration: 2 mg/m3/4 hour/4 week- intermittent Endocrine: Hyperglycemia

Blood: Changes in leukocyte (WBC) count

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		GISAAA 30(2),34,1965
intraperitoneal
guinea pig 		lowest published toxic dose: 780 mg/kg/30 day- intermittent Liver: Other changes

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases 		AMASA4 34,87,1977
oral
rat 		lowest published toxic dose: 45,500 µg/kg/26 week- intermittent Liver: Other changes

Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases 		GISAAA 41(6),12,1976


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.2 mg/m3 (skin) DTLVS* TLV/BEI,2003
TOXICOLOGY REVIEW
DTTIAF 80,485,1973
TOXICOLOGY REVIEW
FNSCA6 2,67,1973


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Cancelled RBREV* -,175,1998
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 0.2 mg/m3 (skin) DTLVS* 3,93,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 0.2 mg/m3 (skin) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 0.2 mg/m3 (skin) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 0.2 mg/m3 (skin) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 0.2 mg/m3 (skin) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRIA MAK 0.2 mg/m3, Skin, JAN1999
Occupational Exposure Limit - DENMARK time-weighted average 0.2 mg/m3, Skin, JAN1999
Occupational Exposure Limit - FRANCE VME 0.2 mg/m3, Skin, JAN1999
Occupational Exposure Limit - NORWAY time-weighted average 25 ppm (125 mg/m3), JAN1999
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 0.2 mg/m3, short term exposure limit 0.6 mg/m3, Skin, SEP2000
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 0.2 mg/m3, Skin, 2003


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO DINITRO-o-CRESOL-air 10 hour time-weighted average 0.2 mg/m3 (Sk) NIOSH* DHHS #92-100,1992


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
ATSDR TOXICOLOGY PROFILE (NTIS** PB/95/264321)
EPA GENETOX PROGRAM 1988, Negative: Rodent dominant lethal
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as free radical polymerization inhibitor and agricultural chemical intermediate
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
85DCAI "Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena, J.M., Springfield, IL, C.C. Thomas, 1970
85DPAN "Wirksubstanzen der Pflanzenschutz und Schadlingsbekampfungsmittel," Perkow, W., Berlin, Verlag Paul Parey, 1971-1976
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
AIDZAC Aichi Ika Daigaku Igakkai Zasshi. Journal of the Aichi Medical University Association. (Aichi Ika Daigaku Igakkai, Yazako, Nagakute-machi, Aichi-gun, Aichi-ken, Japan) V.1- 1973-
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898-
AMASA4 Acta Medica Academiae Scientiarum Hungaricae. (Budapest, Hungary) V.1-39, 1950-82.
AMRL** Aerospace Medical Research Laboratory Report. (Aerospace Technical Div., Air Force Systems Command, Wright-Patterson Air Force Base, OH 45433)
ATSUDG Archives of Toxicology, Supplement. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) No.1- 1978-
BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958-
BIZNAT Biologisches Zentralblatt. (VEB Georg Thieme, Postfach 946, Leipzig DDR-7010, Ger. Dem. Rep.) V.1- 1881-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CMEP** "Clinical Memoranda on Economic Poisons," U.S. Dept. HEW, Public Health Service, Communicable Disease Center, Atlanta, GA, 1956
DEVEAA Defense des Vegetaux. (Federation Nationale des Groupements de Protection des Cultures, 149, rue de Bercy, 75595 Paris Cedex, 12, France) V.1- 1947-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
DTTIAF Deutsche Tieraerztliche Wochenschrift. (Hanover, Fed. Rep. Ger.) V.1-77, 1893-1970.
FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939-
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
FNSCA6 Forensic Science. (Lausanne, Switzerland) V.1-11, 1972-78. For pub lisher information, see FSINDR.
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
HBPTO* Handbook of pesticide toxicology. Robert Krieger ed, Academic press, 2001
HYSAAV Hygiene and Sanitation (USSR). English translation of GISAAA. (Springfield, VA) 1964-71. Discontinued.
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU.
JPPMAB Journal of Pharmacy and Pharmacology. (Pharmaceutical Soc. of Great Britain, 1 Lambeth High St., London SEI 7JN, UK) V.1- 1949-
JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of Toxicological Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku, Tokyo 113, Japan) V.1- 1976-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
SMEZA5 Sudebno-Meditsinskaya Ekspertiza. Forensic Medical Examination. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1958-
STBIBN Studia Biophysica. (Akademie-Verlag GmbH, Postfach 1233, Berlin DDR-1086, Ger. Dem. Rep.) V.1- 1966-
TGANAK Tsitologiya i Genetika. Cytology and Genetics. For English translation, see CYGEDX. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1967-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
WRPCA2 World Review of Pest Control. (London, UK) V.1-10, 1962-71. Discontinued.

Used as free radical polymerization inhibitor and agricultural chemical intermediate

RTECS Compound Description:
   Agricultural Chemical
   Mutagen
   Reproductive Effector
   Human Data
   Primary Irritant

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