The Registry of Toxic Effects of Chemical Substances

p - Cresol, 2,6 - di - tert - butyl -

RTECS #: GO7875000

CAS #: 128-37-0

UPDATE: November 2004 MW: 220.39 MF: C15H24O


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. TUMORIGENIC DATA:
  6. ACUTE TOXICITY DATA:
  7. OTHER MULTIPLE DOSE DATA:
  8. REVIEWS:
  9. STANDARDS AND REGULATIONS:
  10. NIOSH DOCUMENTATION AND SURVEILLANCE:
  11. STATUS IN FEDERAL AGENCIES:
  12. REFERENCES:

SYNONYMS:

  1. 2,6 - Bis (1,1 - dimethylethyl) - 4 - methylphenol
  2. 2,6 - Di - terc.butyl - p - kresol (Czech)
  3. 2,6 - Di - tert - butyl - 1 - hydroxy - 4 - methylbenzene
  4. 2,6 - Di - tert - butyl - 4 - methylphenol
  5. 2,6 - Di - tert - butyl - p - cresol
  6. 2,6 - Di - tert - butyl - p - cresol (ACGIH)
  7. 2,6 - Di - tert - butyl - p - methylphenol
  8. 3,5 - Di - tert - butyl - 4 - hydroxytoluene
  9. 4 - Hydroxy - 3,5 - di - tert - butyltoluene
  10. 4 - Methyl - 2,6 - di - terc. butylfenol (Czech)
  11. 4 - Methyl - 2,6 - di - tert - butylphenol
  12. AO 29
  13. AO 4K
  14. Advastab 401
  15. Agidol
  16. Agidol 1
  17. Alkofen BP
  18. Antioxidant 29
  19. Antioxidant 30
  20. Antioxidant 4
  21. Antioxidant 4K
  22. Antioxidant DBPC
  23. Antioxidant KB
  24. Antrancine 8
  25. BHT
  26. BHT (food grade)
  27. BUKS
  28. Butylated hydroxytoluene
  29. Butylhydroxytoluene
  30. Butylohydroksytoluenu (Polish)
  31. CAO 1
  32. CAO 3
  33. Catalin cao - 3
  34. Chemanox 11
  35. DBMP
  1. DBPC
  2. DBPC (technical grade)
  3. Dalpac
  4. Deenax
  5. Dibunol
  6. Dibutylated hydroxytoluene
  7. Impruvol
  8. Ionol
  9. Ionol (antioxidant)
  10. Ionol 1
  11. Ionol CP
  12. Ionole
  13. Kerabit
  14. Methyldi - tert - butylphenol
  15. NCI - C03598
  16. Nocrac 200
  17. Nonox TBC
  18. P 21
  19. Parabar 441
  20. Paranox 441
  21. Phenol, 2,6 - bis (1,1 - dimethylethyl) - 4 - methyl - (9CI)
  22. Stavox
  23. Sumilizer BHT
  24. Sustane BHT
  25. Swanox BHT
  26. Tenamene 3
  27. Tenox BHT
  28. Topanol
  29. Topanol O
  30. Topanol OC
  31. Toxolan P
  32. Vanlube PC
  33. Vanlube PCX
  34. Vianol
  35. Vulkanox KB


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		100 mg/24 hour moderate 85JCAE -,229,1986
skin
human 		500 mg/48 hour mild AMIHBC 5,311,1952
skin
rabbit 		500 mg/48 hour moderate AMIHBC 5,311,1952


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis hamster ovary 100 µg/L MUREAV 345,73,1995
dominant lethal test oral
mouse 		12 gm/kg/10 week- continuous NTIS** PB278-026
dominant lethal test oral
rat 		5,460 mg/kg/10 week- continuous ENMUDM 8,357,1986
DNA damage oral
mouse 		100 mg/kg MUREAV 519,103,2002
DNA damage oral
rat 		1,400 mg/kg FCTOD7 25,603,1987
DNA inhibition human HeLa cell 500 µmol/L CRNGDP 13,2389,1992
DNA inhibition human lymphocyte 20 µmol/L BBRCA9 80,963,1978
DNA inhibition intraperitoneal
mouse 		250 mg/kg CBINA8 19,279,1977
unscheduled DNA synthesis oral
rat 		16,800 mg/kg/4 week- continuous TXAPA9 99,37,1989
unscheduled DNA synthesis rat liver 100 pmol/L CRNGDP 5,1547,1984
unscheduled DNA synthesis intraperitoneal
rat 		1,200 mg/kg/3 day- continuous DANKAS 287,371,1986
mutation in microorganisms mouse lymphocyte 6 mg/L (+enzymatic activation step) EMMUEG 11,91,1988
mutation in mammalian somatic cells mouse lymphocyte 6 mg/L EMMUEG 11,91,1988
other mutation test systems oral
mouse 		500 mg/kg MUREAV 343,157,1995
sperm morphology intraperitoneal
mouse 		350 mg/kg/5 day- intermittent CMMUAO 5,257,1978


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 43,800 mg/kg (52 day prior to copulation/1-21 day pregnant) Reproductive: Maternal effects: Parturition

Reproductive: Effects on newborn: Weaning or lactation index (e.g., # alive at weaning per # alive at day 4)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) 		FCTXAV 3,371,1965
oral
mouse 		lowest published toxic dose: 12,600 mg/kg (1-21 day pregnant) Reproductive: Effects on newborn: Behavioral FEPRA7 31,596,1972
oral
mouse 		lowest published toxic dose: 1,200 mg/kg (9 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system TRENAF 28(2),45,1977
oral
rat 		lowest published toxic dose: 6 gm/kg (13 week male/13 week prior to copulation-3 week after birth) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) FCTOD7 24,1,1986
oral
rat 		lowest published toxic dose: 18 gm/kg (2 week male/2 week prior to copulation-3 week after birth) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Behavioral 		FCTXAV 19,153,1981
oral
rat 		lowest published toxic dose: 9 gm/kg (2 week male/2 week prior to copulation-3 week after birth) Reproductive: Effects on newborn: Weaning or lactation index (e.g., # alive at weaning per # alive at day 4) FCTXAV 19,153,1981
oral
rat 		lowest published toxic dose: 35 gm/kg (10 week male) Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea) ENMUDM 8,357,1986


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 435 mg/kg/69 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Gastrointestinal: Tumors 		FCTXAV 12,367,1974
oral
mouse 		toxic dose : 1,423 mg/kg/43 week- continuous Tumorigenic: Neoplastic by RTECS criteria

Liver: Tumors 		TXCYAC 38,151,1986
oral
mouse 		lowest published toxic dose: 1,200 mg/kg/3 week- intermittent Tumorigenic: Neoplastic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Tumorigenic: Tumor types after systemic administration not seen spontaneously 		CALEDQ 145,101,1999
oral
rat 		lowest published toxic dose: 134 gm/kg/32 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Kidney, Ureter, and Bladder: Bladder tumors

Tumorigenic: Cells (cultured) transformed 		CRNGDP 4,895,1983
oral
rat 		toxic dose : 247 gm/kg/3 year- continuous Tumorigenic: Carcinogenic by RTECS criteria

Reproductive: Tumorigenic effects: Transplacental tumorigenesis

Liver: Tumors 		FCTOD7 24,1,1986
oral
rat 		toxic dose : 247 gm/kg/3 year- continuous Tumorigenic: Neoplastic by RTECS criteria

Reproductive: Tumorigenic effects: Ovarian tumors 		FCTOD7 24,1,1986
oral
rat 		toxic dose : 247 gm/kg Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors 		FCTOD7 24,1121,1986
oral
rat 		toxic dose : 963 gm/kg Tumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Tumors 		FCTOD7 24,1071,1986


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lethal dose (50 percent kill): 138 mg/kg Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion

Lung, Thorax, or Respiration: Other changes

Blood: Hemorrhage 		TXAPA9 61,475,1981
intraperitoneal
mouse 		lethal dose (50 percent kill): 150 mg/kg N/R VCVGK* -,212,1994
intraperitoneal
mouse 		lowest published toxic dose: 100 mg/kg Lung, Thorax, or Respiration: Fibrosis (interstitial)

Lung, Thorax, or Respiration: Changes in lung weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		VCVGK* -,212,1994
intraperitoneal
mouse 		lethal dose (50 percent kill): 138 mg/kg Lung, Thorax, or Respiration: Acute pulmonary edema

Blood: Hemorrhage 		IJOTO* 21,19,2002
intraperitoneal
rat 		lowest published toxic dose: 10 mg/kg Liver: Other changes

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Metabolism (intermediary): Lipids including transport 		FATOAO 55,34,1992
intraperitoneal
rat 		lethal dose (50 percent kill): 8 gm/kg N/R IJOTO* 21,19,2002
intravenous
mouse 		lethal dose (50 percent kill): 180 mg/kg Behavioral: Sleep JMCMAR 23,1350,1980
oral
cat 		lowest published lethal dose: 940 mg/kg Gastrointestinal: Hypermotility, diarrhea

Behavioral: Tremor

Lung, Thorax, or Respiration: Respiratory depression 		AMIHAB 11,93,1955
oral
cat 		lowest published lethal dose: 940 mg/kg N/R VCVGK* -,212,1994
oral
guinea pig 		lethal dose (50 percent kill): 10,700 mg/kg Gastrointestinal: Hypermotility, diarrhea

Behavioral: Tremor

Lung, Thorax, or Respiration: Respiratory depression 		AMIHAB 11,93,1955
oral
guinea pig 		lethal dose (50 percent kill): 10,700 mg/kg N/R VCVGK* -,212,1994
oral
mouse 		lethal dose (50 percent kill): 650 mg/kg Behavioral: Tremor

Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion 		SRTCAC 36(1-4),10,1989
oral
mouse 		lowest published toxic dose: 50 mg/kg Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation EKFAE9 62,56,1999
oral
mouse 		lethal dose (50 percent kill): 1,040 mg/kg N/R VCVGK* -,212,1994
oral
mouse 		lethal dose (50 percent kill): 650 mg/kg Behavioral: Tremor

Behavioral: Ataxia

Lung, Thorax, or Respiration: Other changes 		IJOTO* 21,19,2002
oral
rat 		lowest published toxic dose: 25 mg/kg Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes 		EKFAE9 62,56,1999
oral
rat 		lethal dose (50 percent kill): 890 mg/kg N/R VCVGK* -,212,1994
oral
rabbit 		lowest published lethal dose: 2,100 mg/kg Gastrointestinal: Hypermotility, diarrhea

Behavioral: Tremor

Lung, Thorax, or Respiration: Respiratory depression 		AMIHAB 11,93,1955
oral
rabbit 		lethal dose (50 percent kill): 2,100 mg/kg N/R VCVGK* -,212,1994
oral
rabbit 		lowest published lethal dose: 2,000 mg/kg N/R VCVGK* -,212,1994
oral
woman 		lowest published toxic dose: 80 mg/kg Behavioral: Coma

Gastrointestinal: Gastritis

Gastrointestinal: Nausea or vomiting 		NEJMAG 314,648,1986
rectal
mouse 		lowest published toxic dose: 50 mg/kg Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation EKFAE9 62,56,1999
rectal
rat 		lowest published toxic dose: 25 mg/kg Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes 		EKFAE9 62,56,1999


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
guinea pig 		lowest published toxic dose: 570 mg/kg/3 day- intermittent Blood: Change in clotting factors VCVGK* -,212,1994
intraperitoneal
hamster 		lowest published toxic dose: 1,140 mg/kg/3 day- intermittent Brain and Coverings: Changes in circulation

Behavioral: Tremor 		VCVGK* -,212,1994
intraperitoneal
mouse 		lowest published toxic dose: 750 mg/kg/3 week- intermittent Lung, Thorax, or Respiration: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation 		TXCYAC 169,1,2001
intraperitoneal
mouse 		lowest published toxic dose: 750 mg/kg/3 week- intermittent Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation TXCYAC 169,1,2001
intraperitoneal
mouse 		lowest published toxic dose: 1,750 mg/kg/1 week- intermittent Gastrointestinal: Tumors

Liver: Tumors

Kidney, Ureter, and Bladder: Bladder tumors 		VCVGK* -,213,1994
intraperitoneal
rabbit 		lowest published toxic dose: 480 mg/kg/4 day- intermittent Cardiac: Other changes

Biochemical: Metabolism (intermediary): Lipids including transport 		FATOAO 55,19,1992
oral
hamster 		lowest published toxic dose: 1,596 mg/kg/14 day- continuous Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases 		FCTOD7 34,595,1996
oral
monkey 		lowest published toxic dose: 14 gm/kg/4 week- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases FCTXAV 10,769,1972
oral
mouse 		lowest published toxic dose: 13,500 mg/kg/18 day- intermittent Liver: Changes in liver weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes 		FCTXAV 3,417,1965
oral
mouse 		lowest published toxic dose: 48,600 mg/kg/30 day- continuous Lung, Thorax, or Respiration: Changes in lung weight

Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) 		FCTOD7 30,89,1992
oral
mouse 		lowest published toxic dose: 2,000 mg/kg/4 day- intermittent Liver: Multiple effects

Kidney, Ureter, and Bladder: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		VCVGK* -,212,1994
oral
mouse 		lowest published toxic dose: 10.08 mg/kg/1 week- continuous Brain and Coverings: Changes in circulation

Blood: Hemorrhage

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		VCVGK* -,212,1994
oral
rat 		lowest published toxic dose: 5,185 mg/kg/4 week- continuous Liver: Other changes

Liver: Changes in liver weight 		TOLED5 87,103,1996
oral
rat 		lowest published toxic dose: 109 gm/kg/2 year- continuous Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Blood: Changes in erythrocyte (RBC) count

Blood: Changes in leukocyte (WBC) count 		FCTXAV 19,147,1981
oral
rat 		lowest published toxic dose: 27 gm/kg/90 day- continuous Liver: Changes in liver weight

Endocrine: Evidence of thyroid hyperfunction

Endocrine: Changes in thyroid weight 		TOLED5 10,239,1982
oral
rat 		lowest published toxic dose: 37,800 mg/kg/6 week- continuous Liver: Changes in liver weight

Endocrine: Changes in adrenal weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		AJEBAK 39,353,1961
oral
rat 		lowest published toxic dose: 5,600 mg/kg/16 week- continuous Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Other changes in urine composition 		FCTXAV 3,433,1965
oral
rat 		lowest published toxic dose: 275 mg/kg/26 week- continuous Liver: Changes in liver weight

Skin and Appendages: Other: Hair

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		AJEBAK 37,533,1959
oral
rat 		lowest published toxic dose: 112 gm/kg/80 week- continuous Liver: Changes in liver weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)

Biochemical: Metabolism (intermediary): Other proteins 		TXCYAC 7,289,1977
oral
rat 		lowest published toxic dose: 5,040 mg/kg/7 day- continuous Liver: Changes in liver weight

Blood: Changes in erythrocyte (RBC) count

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases 		APTOA6 49,14,1981
oral
rat 		lowest published toxic dose: 1,200 mg/kg/3 day- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases FATOAO 50,81,1987
oral
rat 		lowest published toxic dose: 840 mg/kg/14 day- intermittent Cardiac: Other changes

Biochemical: Metabolism (intermediary): Lipids including transport 		EKFAE9 56,47,1993
oral
rat 		lowest published toxic dose: 350 mg/kg/7 day- intermittent Gastrointestinal: Other changes

Liver: Other changes 		FATOAO 47,87,1984
oral
rat 		lowest published toxic dose: 350 mg/kg/7 day- intermittent Gastrointestinal: Other changes FATOAO 47,87,1984
oral
rat 		lowest published toxic dose: 500 mg/kg/5 day- intermittent Gastrointestinal: Other changes

Biochemical: Metabolism (intermediary): Lipids including transport 		EKFAE9 61,21,1998
oral
rat 		lowest published toxic dose: 39.7 mg/kg/3 day- intermittent Blood: Change in clotting factors EKFAE9 62,38,1999
oral
rat 		lowest published toxic dose: 6,300 mg/kg/6 week- continuous Liver: Tumors

Tumorigenic: Protects against induction of experimental tumors

Tumorigenic: Active as anti-cancer agent 		CALEDQ 143,173,1999
oral
rat 		lowest published toxic dose: 2.625 mg/kg/1 week- continuous Liver: Other changes

Blood: Change in clotting factors

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects 		VCVGK* -,212,1994
oral
rat 		lowest published toxic dose: 2,000 mg/kg/4 day- intermittent Liver: Multiple effects

Kidney, Ureter, and Bladder: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		VCVGK* -,212,1994
oral
rat 		lowest published toxic dose: 6.3 mg/kg/1 week- continuous Brain and Coverings: Changes in circulation

Blood: Hemorrhage

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		VCVGK* -,212,1994
oral
rat 		lowest published toxic dose: 547.5 mg/kg/2 year- continuous Brain and Coverings: Changes in brain weight

Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		VCVGK* -,213,1994
oral
turkey 		lowest published toxic dose: 4,000 ppm/10 day- continuous Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) FCTOD7 41,671,2003
skin
mouse 		lowest published toxic dose: 5 gm/kg/4 week- intermittent Lung, Thorax, or Respiration: Changes in lung weight

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		TOLED5 34,99,1986


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 2 mg/m3 ( intermittent,V) DTLVS* TLV/BEI,2003
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not Classifiable as a Human Carcinogen DTLVS* TLV/BEI,2003
International Agency for Research on Cancer (IARC) Cancer Review Animal Limited Evidence IMEMDT 40,161,1986
International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Data IMEMDT 40,161,1986
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMSUDL 7,56,1987
TOXICOLOGY REVIEW
IJOTO* 21,19,2002


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - AUSTRALIA time-weighted average 10 mg/m3, JAN1993
Occupational Exposure Limit - AUSTRIA MAK 10 mg/m3, JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 10 mg/m3, JAN1993
Occupational Exposure Limit - FINLAND time-weighted average 10 mg/m3, short term exposure limit 20 mg/m3, Skin, JAN1999
Occupational Exposure Limit - FRANCE VME 10 mg/m3, JAN1999
Occupational Exposure Limit - GERMANY No MAK Established, JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 10 mg/m3, JAN1999
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 10 mg/m3, 2003
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Not Classifiable as a Human Carcinogen
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Not Classifiable as a Human Carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO 2,6-DI-t-BUTYL-p-CRESOL-air 10 hour time-weighted average 10 mg/m3 NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 83383;
Number of Industries 32;
Total Number of Facilities 1,526;
Number of Occupations 39;
Total Number of Employees Exposed 28,860
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 83383;
Number of Industries 210;
Total Number of Facilities 27,242;
Number of Occupations 154;
Total Number of Employees Exposed 591,238;
Total Number of Female Employees Exposed 163,774


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Positive: D melanogaster-whole sex chrom. loss
EPA GENETOX PROGRAM 1988, Negative: Histidine reversion-Ames test; Mouse specific locus
EPA GENETOX PROGRAM 1988, Negative: D melanogaster Sex-linked lethal
EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster-reciprocal translocation
EPA GENETOX PROGRAM 1988, Inconclusive: Mammalian micronucleus; Sperm morphology-mouse
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a food and feed additive, flavor and packaging material
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-9076
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Bioassay (feed);no evidence:mouse,rat NCITR* NCI-TR-150,1979


REFERENCES:

CODEN
REFERENCE
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
AJEBAK Australian Journal of Experimental Biology and Medical Science. (Adelaide, S.A., Australia) V.1-64, 1924-86.
AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21, 1955-60. For publisher information, see AEHLAU.
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine. (Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH
BBRCA9 Biochemical and Biophysical Research Communications. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1975-
CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1969-
CMMUAO Chemical Mutagens. Principles and Methods for Their Detection. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) V.1- 1971-
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
DANKAS Doklady Akademii Nauk SSSR. Proceedings of the Academy of Sciences of the USSR. For English translation, see DBIOAM and DKBSAS. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1933-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EKFAE9 Eksperimental'naya i Klinicheskaya Farmakologiya. Experimental and Clinical Pharmacology. (Mezhdunarodnaya Kniga, ul. B. Yakimanka, 39, 117049 Moscow, Russia) V.55- 1992-
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG.
FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939-
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7.
FEPRA7 Federation Proceedings, Federation of American Societies for Experimental Biology. (Bethesda, MD) V.1-46, 1942-87.
IJOTO* International Journal of Toxicology (Continous: Journal of the American College of Toxicology,Taylor & Francis Health Sciences) V.16- 1997-
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979-
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Used as a food and feed additive, flavor and packaging material

RTECS Compound Description:
   Tumorigen
   Drug
   Mutagen
   Reproductive Effector
   Human Data
   Primary Irritant

ALT CAS #: 58500-82-6
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