The Registry of Toxic Effects of Chemical Substances

m - Cresol, 4 - chloro -

RTECS #: GO7100000

CAS #: 59-50-7

UPDATE: November 2004 MW: 142.59 MF: C7H7ClO


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. STANDARDS AND REGULATIONS:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. Aptal
  2. Baktol
  3. Baktolan
  4. Candaseptic
  5. p - Chlor - m - cresol
  6. Chlorocresol
  7. p - Chloro - m - cresol
  8. 4 - Chloro - m - cresol
  9. 4 - Chloro - 3 - methylphenol
  10. 3 - Methyl - 4 - chlorophenol
  1. Parol
  2. PCMC
  3. Peritonan
  4. Preventol CMK
  5. Raschit
  6. Raschit K
  7. Rasen - Anicon
  8. RCRA waste number U039
  9. Ottafact
  10. Phenol, 4 - chloro - 3 - methyl - (9CI)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
mutation in microorganisms Salmonella typhimurium 25 µg/plate (-enzymatic activation step) TECSDY 14,143,1987
other mutation test systems Escherichia coli 100 µmol/L MUREAV 307,141,1994


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intravenous
mouse 		lethal dose (50 percent kill): 70 mg/kg Behavioral: Coma

Lung, Thorax, or Respiration: Other changes 		QJPPAL 12,212,1939
oral
mouse 		lethal dose (50 percent kill): 600 mg/kg Behavioral: Somnolence (general depressed activity) SRTCAC 36(1-4),10,1989
oral
rat 		lethal dose (50 percent kill): 1,830 mg/kg N/R SchP## 04APR1986
subcutaneous
mouse 		lethal dose (50 percent kill): 360 mg/kg Behavioral: General anesthetic

Behavioral: Tremor

Lung, Thorax, or Respiration: Other changes 		QJPPAL 12,212,1939
subcutaneous
rat 		lethal dose (50 percent kill): 400 mg/kg N/R QJPPAL 12,212,1939


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 11,200 mg/kg/28 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain BECTA6 37,651,1986
skin
mouse 		lowest published toxic dose: 600 mg/kg/3 day- intermittent Skin: After topical application: Cutaneous sensitization (experimental)

Immunological Including Allergic: Increase in cellular immune response 		TXCYAC 190,259,2003


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: RED Completed RBREV* -,245,1998
Occupational Exposure Limit - SWEDEN time-weighted average 3 mg/m3, short term exposure limit 6 mg/m3, JAN1999
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 3 mg/m3, 2003


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 84772;
Number of Industries 2;
Total Number of Facilities 29;
Number of Occupations 12;
Total Number of Employees Exposed 876
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 84772;
Number of Industries 65;
Total Number of Facilities 5,608;
Number of Occupations 62;
Total Number of Employees Exposed 175,929;
Total Number of Female Employees Exposed 24,335


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a preservative in pharmaceutical products and cutting oils
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
BECTA6 Bulletin of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1966-
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
QJPPAL Quarterly Journal of Pharmacy & Pharmacology. (London, UK) V.2-21, 1929-48. For publisher information, see JPPMAB.
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
SRTCAC Science Reports of the Research Institutes, Tohoku University, Series C: Medicine. (Tohoku University, Research Institute for Tuberculosis and Cancer, 4-1 Seiryo-machi, Sendai, Japan) V.1- 1949-
SchP## Personal Communication from P. Schmitz, Bayer AG, 5090 Leverkusen, Bayerwerk, Fed. Rep. Ger., April 4, 1986
TECSDY Toxicological and Environmental Chemistry. (Gordon & Breach Science Pub. Inc., 1 Park Ave., New York, NY 10016) V.3(3/4)- 1981-
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-

Used as a preservative in pharmaceutical products and cutting oils

RTECS Compound Description:
   Mutagen

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