The Registry of Toxic Effects of Chemical Substances

o - Cresol

RTECS #: GO6300000

CAS #: 95-48-7

UPDATE: May 2004 MW: 108.15 MF: C7H8O


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. TUMORIGENIC DATA:
  6. ACUTE TOXICITY DATA:
  7. OTHER MULTIPLE DOSE DATA:
  8. REVIEWS:
  9. STANDARDS AND REGULATIONS:
  10. NIOSH DOCUMENTATION AND SURVEILLANCE:
  11. STATUS IN FEDERAL AGENCIES:
  12. REFERENCES:

SYNONYMS:

  1. 1 - Hydroxy - 2 - methylbenzene
  2. 2 - Cresol
  3. 2 - Hydroxytoluene
  4. 2 - Methylphenol
  5. Orthocresol
  6. Phenol, 2 - methyl - (9CI)
  7. RCRA waste number U052
  8. m - Cresol
  1. o - Cresol (ACGIH:OSHA)
  2. o - Cresylic acid
  3. o - Hydroxytoluene
  4. o - Kresol (German)
  5. o - Methylphenol
  6. o - Methylphenylol
  7. o - Oxytoluene
  8. o - Toluol


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		105 mg severe BIOFX* 4-5/1969
skin
rabbit 		524 mg/24 hour severe BIOFX* 4-5/1969


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
sister chromatid exchange human fibroblast 8 mmol/L MUREAV 137,51,1984


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 2.31 gm/kg (7 day prior to copulation/21 day pregnant) Reproductive: Maternal effects: Parturition NTIS** #PB92-176890
oral
mouse 		lowest published toxic dose: 660 mg/kg (multigenerations) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) NTIS** #PB92-176890


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
skin
mouse 		lowest published toxic dose: 4,800 mg/kg/12 week- intermittent Tumorigenic: Neoplastic by RTECS criteria

Skin and Appendages: Tumors 		CNREA8 19,413,1959


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mouse 		lethal concentration (50 percent kill): 179 mg/m3/2 hour N/R 85GMAT -,40,1982
inhalation
mouse 		lethal concentration (50 percent kill): 179 mg/m3 Behavioral: Tetany

Lung, Thorax, or Respiration: Acute pulmonary edema

Kidney, Ureter, and Bladder: Hematuria 		VCVGK* -,207,1994
inhalation
rat 		lethal concentration (50 percent kill): >1,220 mg/m3/1 hour Eye: Lacrimation

Behavioral: Somnolence (general depressed activity) 		BIOFX* 4-5/1969
inhalation
rat 		lethal concentration (50 percent kill): 29 mg/m3 Behavioral: Tetany

Lung, Thorax, or Respiration: Acute pulmonary edema

Kidney, Ureter, and Bladder: Hematuria 		VCVGK* -,207,1994
intraperitoneal
guinea pig 		lowest published lethal dose: 360 mg/kg N/R VCVGK* -,207,1994
intraperitoneal
mouse 		lowest published lethal dose: 200 mg/kg N/R RBPMAZ 22,1,1952
intraperitoneal
rabbit 		lowest published lethal dose: 180 mg/kg N/R VCVGK* -,207,1994
intravenous
dog 		lowest published lethal dose: 80 mg/kg N/R VCVGK* -,207,1994
intravenous
rabbit 		lowest published lethal dose: 180 mg/kg N/R JPETAB 80,233,1944
oral
mammal (species unspecified) 		lethal dose (50 percent kill): 100 mg/kg Cardiac: Other changes

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes 		VCVGK* -,207,1994
oral
mouse 		lethal dose (50 percent kill): 344 mg/kg N/R GTPZAB 18(2),58,1974
oral
mouse 		lethal dose (50 percent kill): 344 mg/kg Cardiac: Other changes

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes 		VCVGK* -,207,1994
oral
rat 		lethal dose (50 percent kill): 121 mg/kg Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Dyspnea

Gastrointestinal: Ulceration or bleeding from stomach 		BIOFX* 4-5/1969
oral
rat 		lethal dose (50 percent kill): 1,350 mg/kg Cardiac: Other changes

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes 		VCVGK* -,207,1994
oral
rabbit 		lowest published lethal dose: 940 mg/kg N/R JPETAB 80,233,1944
oral
rabbit 		lethal dose (50 percent kill): 940 mg/kg Cardiac: Other changes

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes 		VCVGK* -,207,1994
subcutaneous
cat 		lowest published lethal dose: 55 mg/kg N/R VCVGK* -,207,1994
subcutaneous
frog 		lowest published lethal dose: 200 mg/kg N/R HBAMAK 4,1361,1935
subcutaneous
guinea pig 		lowest published lethal dose: 35 mg/kg Eye: Miosis (pupilliary constriction)

Behavioral: Excitement

Lung, Thorax, or Respiration: Acute pulmonary edema 		RMSRA6 15,561,1895
subcutaneous
mouse 		lowest published lethal dose: 410 mg/kg N/R VCVGK* -,207,1994
subcutaneous
rat 		lowest published lethal dose: 65 mg/kg Eye: Miosis (pupilliary constriction)

Behavioral: Excitement

Lung, Thorax, or Respiration: Acute pulmonary edema 		RMSRA6 15,561,1895
subcutaneous
rat 		lowest published lethal dose: 65 mg/kg N/R VCVGK* -,207,1994
subcutaneous
rabbit 		lowest published lethal dose: 450 mg/kg N/R HBAMAK 4,1361,1935
skin
rat 		lethal dose (50 percent kill): 620 mg/kg N/R GTPZAB 18(2),58,1974
skin
rat 		lethal dose (50 percent kill): 620 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Tetany 		VCVGK* -,207,1994
skin
rabbit 		lethal dose (50 percent kill): 890 mg/kg N/R TXAPA9 42,417,1977
skin
rabbit 		lethal dose (50 percent kill): 890 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Tetany 		VCVGK* -,207,1994


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
guinea pig 		lowest published toxic concentration: 9 mg/m3/4 hour/122 day- intermittent Brain and Coverings: Other degenerative changes

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes 		VCVGK* -,208,1994
inhalation
mouse 		lowest published toxic concentration: 50 mg/m3/2 hour/24 day- intermittent Brain and Coverings: Other degenerative changes

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes 		VCVGK* -,208,1994
inhalation
rat 		lowest published toxic concentration: 10 mg/m3/4 hour/40 day- intermittent Brain and Coverings: Other degenerative changes

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes 		VCVGK* -,208,1994
inhalation
rat 		lowest published toxic concentration: 9 mg/m3/4 hour/122 day- intermittent Brain and Coverings: Other degenerative changes

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes 		VCVGK* -,208,1994
inhalation
rabbit 		lowest published toxic concentration: 9 mg/m3/4 hour/122 day- intermittent Brain and Coverings: Other degenerative changes

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes 		VCVGK* -,208,1994
oral
mammal (species unspecified) 		lowest published toxic dose: 1,169 mg/kg/28 day- continuous Liver: Changes in liver weight ETOCDK 5,713,1986
oral
mouse 		lowest published toxic dose: 101 gm/kg/28 day- continuous Brain and Coverings: Changes in brain weight

Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		NTIS** PB92-174242
oral
mouse 		lowest published toxic dose: 218 gm/kg/13 week- continuous Brain and Coverings: Changes in brain weight

Endocrine: Changes in thymus weight

Related to Chronic Data: Changes in testicular weight 		NTIS** PB92-174242
oral
mouse 		lowest published toxic dose: 18,480 mg/kg/28 day- continuous Kidney, Ureter, and Bladder: Changes in kidney weight NTIS** #PB92-176890
oral
rat 		lowest published toxic dose: 21 gm/kg/28 day- continuous Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight 		NTIS** PB92-174242
oral
rat 		lowest published toxic dose: 82 gm/kg/13 week- continuous Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight

Endocrine: Changes in thymus weight 		NTIS** PB92-174242


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 5 ppm (skin) DTLVS* TLV/BEI,2002
TOXICOLOGY REVIEW
MUREAV 47,75,1978


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 5 ppm (22 mg/m3) DTLVS* 3,61,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 5 ppm (22 mg/m3) (skin) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 5 ppm (22 mg/m3) (skin) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 5 ppm (22 mg/m3) (skin) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 5 ppm (22 mg/m3) (skin) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRIA MAK 5 ppm (22 mg/m3), Skin, JAN1999
Occupational Exposure Limit - DENMARK time-weighted average 5 ppm (22 mg/m3), Skin, JAN1999
Occupational Exposure Limit - FRANCE VME 5 ppm (22 mg/m3), JAN1999
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 5 ppm (22 mg/m3), JAN1999
Occupational Exposure Limit - NORWAY time-weighted average 5 ppm (22 mg/m3), JAN1999
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 5 ppm (22 mg/m3), Skin, SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 5 ppm (skin)
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 5 ppm (skin)


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO o-CRESOL-air 10 hour time-weighted average 2.3 ppm NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 84364;
Number of Industries 26;
Total Number of Facilities 1,724;
Number of Occupations 28;
Total Number of Employees Exposed 14,550
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 84364;
Number of Industries 16;
Total Number of Facilities 1,707;
Number of Occupations 24;
Total Number of Employees Exposed 10,985;
Total Number of Female Employees Exposed 483


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE FEREAC 47,26992,82
Used as a disinfectant
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Cresol (all isomers) and phenol, 2546
NIOSH Analytical Method, 1996: Volatile organic compound, 2549
NTP Toxicity studies, RPT# TOX-09, October 2000


REFERENCES:

CODEN
REFERENCE
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982
BIOFX* BIOFAX Industrial Bio-Test Laboratories, Inc., Data Sheets. (1810 Frontage Rd., Northbrook, IL 60062)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
ETOCDK Environmental Toxicology and Chemistry. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1982-
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig, Ger. Dem. Rep.)
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
RBPMAZ Revue Belge de Pathologie et de Medecine Experimentale. (Brussels, Belgium) V.18-31, 1947-65. For publisher information, see PTEUA6.
RMSRA6 Revue Medicale de la Suisse Romande. (Societe Medicale de La Suisse Romande, 2 rue Bellefontaine, 1003 Lausanne, Switzerland) V.1- 1881-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.

Used as a disinfectant

RTECS Compound Description:
   Tumorigen
   Mutagen
   Reproductive Effector
   Primary Irritant

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