The Registry of Toxic Effects of Chemical Substances

m - Cresol

RTECS #: GO6125000

CAS #: 108-39-4

UPDATE: August 2004 MW: 108.15 MF: C7H8O


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. TUMORIGENIC DATA:
  6. ACUTE TOXICITY DATA:
  7. OTHER MULTIPLE DOSE DATA:
  8. REVIEWS:
  9. STANDARDS AND REGULATIONS:
  10. NIOSH DOCUMENTATION AND SURVEILLANCE:
  11. STATUS IN FEDERAL AGENCIES:
  12. REFERENCES:

SYNONYMS:

  1. 1 - Hydroxy - 3 - methylbenzene
  2. 3 - Cresol
  3. 3 - Hydroxytoluene
  4. 3 - Methylphenol
  5. Cresol
  6. MPCRE)
  7. Mixture of meta and para - cresol (59%:41%
  8. Phenol, 3 - methyl - (9CI)
  9. RCRA waste number U052
  1. m - Cresol (ACGIH:OSHA)
  2. m - Cresole
  3. m - Cresylic acid
  4. m - Hydroxytoluene
  5. m - Kresol
  6. m - Methylphenol
  7. m - Oxytoluene
  8. m - Toluol
  9. o - Cresol


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		103 mg severe BIOFX* 3-5/1969
skin
rabbit 		517 mg/24 hour severe BIOFX* 3-5/1969


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
DNA inhibition human HeLa cell 10 µmol/L/4 hour BECTA6 32,220,1984


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 2,100 mg/kg (multigeneration) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) TOXID9 12,198,1992
oral
rat 		lowest published toxic dose: 1,400 mg/kg (multigeneration) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) TOXID9 12,198,1992
subcutaneous
rabbit 		lowest published toxic dose: 134 gm/kg (6-18 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) OYYAA2 16,1191,1978


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
skin
mouse 		lowest published toxic dose: 2,280 mg/kg/20 week- intermittent Tumorigenic: Neoplastic by RTECS criteria

Skin and Appendages: Tumors 		CNREA8 19,413,1959


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lethal concentration (50 percent kill): >710 mg/m3/1 hour N/R BIOFX* 3-5/1969
inhalation
rat 		lethal concentration (50 percent kill): 58 mg/m3 Behavioral: Tetany

Lung, Thorax, or Respiration: Acute pulmonary edema

Kidney, Ureter, and Bladder: Hematuria 		VCVGK* -,207,1994
intraperitoneal
dog 		lowest published lethal dose: 100 mg/kg N/R VCVGK* -,207,1994
intraperitoneal
guinea pig 		lowest published lethal dose: 100 mg/kg N/R HBAMAK 4,1361,1935
intraperitoneal
mouse 		lethal dose (50 percent kill): 168 mg/kg N/R VCVGK* -,207,1994
intravenous
dog 		lowest published lethal dose: 150 mg/kg N/R VCVGK* -,207,1994
intravenous
rabbit 		lowest published lethal dose: 280 mg/kg N/R VCVGK* -,207,1994
oral
mouse 		lethal dose (50 percent kill): 828 mg/kg N/R GTPZAB 18(2),58,1974
oral
mouse 		lethal dose (50 percent kill): 600 mg/kg Cardiac: Other changes

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes 		VCVGK* -,207,1994
oral
rat 		lethal dose (50 percent kill): 242 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold

Gastrointestinal: Peritonitis 		BIOFX* 3-5/1969
oral
rat 		lethal dose (50 percent kill): 825 mg/kg Kidney, Ureter, and Bladder: Hematuria

Skin: After systemic exposure: Dermatitis, other 		WDZAEK 9,108,1995
oral
rat 		lethal dose (50 percent kill): 242 mg/kg Cardiac: Other changes

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes 		VCVGK* -,207,1994
oral
rabbit 		lowest published lethal dose: 1,400 mg/kg N/R JPETAB 80,233,1944
oral
rabbit 		lethal dose (50 percent kill): 1,400 mg/kg Cardiac: Other changes

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes 		VCVGK* -,207,1994
subcutaneous
cat 		lowest published lethal dose: 180 mg/kg N/R VCVGK* -,207,1994
subcutaneous
frog 		lowest published lethal dose: 250 mg/kg N/R HBAMAK 4,1361,1935
subcutaneous
guinea pig 		lowest published lethal dose: 300 mg/kg N/R VCVGK* -,207,1994
subcutaneous
mouse 		lowest published lethal dose: 450 mg/kg N/R VCVGK* -,207,1994
subcutaneous
rat 		lowest published lethal dose: 900 mg/kg N/R VCVGK* -,207,1994
subcutaneous
rabbit 		lowest published lethal dose: 500 mg/kg N/R HBAMAK 4,1361,1935
subcutaneous
rabbit 		lethal dose (50 percent kill): 2,050 mg/kg N/R VCVGK* -,207,1994
skin
rat 		lethal dose (50 percent kill): 1,100 mg/kg N/R GTPZAB 18(2),58,1974
skin
rat 		lethal dose (50 percent kill): 1,000 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Tetany 		VCVGK* -,207,1994
skin
rabbit 		lethal dose (50 percent kill): 2,050 mg/kg Eye: Lacrimation

Behavioral: Convulsions or effect on seizure threshold

Gastrointestinal: Changes in structure or function of salivary glands 		BIOFX* 3-5/1969
skin
rabbit 		lethal dose (50 percent kill): 620 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Tetany 		VCVGK* -,207,1994
unreported route
mouse 		lethal dose (50 percent kill): 600 mg/kg N/R GTPPAF 8,145,1972


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rabbit 		lowest published toxic concentration: 2 mg/m3/24 hour/6 week- intermittent Kidney, Ureter, and Bladder: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other hydrolases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes 		VMDKAM 24,151,1978
oral
mouse 		lowest published toxic dose: 101 gm/kg/28 day- continuous Brain and Coverings: Changes in brain weight

Kidney, Ureter, and Bladder: Changes in bladder weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		NTIS** PB92-174242
oral
rat 		lowest published toxic dose: 42 gm/kg/28 day- continuous Brain and Coverings: Changes in brain weight

Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight 		NTIS** PB92-174242
oral
rat 		lowest published toxic dose: 1,800 mg/kg/18 day- intermittent Behavioral: Tremor TOXID9 72,390,2003
oral
rat 		lowest published toxic dose: 5,400 mg/kg/18 day- intermittent Lung, Thorax, or Respiration: Respiratory depression

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		TOXID9 72,390,2003
oral
rat 		lowest published toxic dose: 28 gm/kg/28 day- intermittent Behavioral: Tremor

Lung, Thorax, or Respiration: Respiratory depression

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		TOXID9 72,390,2003


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 5 ppm (skin) DTLVS* TLV/BEI,2002
TOXICOLOGY REVIEW
MUREAV 47,75,1978


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: RED Completed RBREV* -,305,1998
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 5 ppm (22 mg/m3) DTLVS* 3,61,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 5 ppm (22 mg/m3) (skin) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 5 ppm (22 mg/m3) (skin) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 5 ppm (22 mg/m3) (skin) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 5 ppm (22 mg/m3) (skin) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRIA MAK 5 ppm (22 mg/m3), Skin, JAN1999
Occupational Exposure Limit - DENMARK time-weighted average 5 ppm (22 mg/m3), Skin, JAN1999
Occupational Exposure Limit - FRANCE VME 5 ppm (22 mg/m3), JAN1999
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 5 ppm (22 mg/m3), JAN1999
Occupational Exposure Limit - NORWAY time-weighted average 5 ppm (22 mg/m3), JAN1999
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 5 ppm (22 mg/m3), Skin, SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 5 ppm (skin)
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 5 ppm (skin)


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO m-CRESOL-air 10 hour time-weighted average 2.3 ppm NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 84497;
Number of Industries 16;
Total Number of Facilities 1,317;
Number of Occupations 20;
Total Number of Employees Exposed 11,161
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 84497;
Number of Industries 5;
Total Number of Facilities 144;
Number of Occupations 11;
Total Number of Employees Exposed 5,615;
Total Number of Female Employees Exposed 1,174


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE FEREAC 47,26992,82
Used as a disinfectant and fumigant
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Cresol (all isomers) and phenol, 2546
NIOSH Analytical Method, 1996: Volatile organic compound, 2549
NTP Toxicity studies, RPT# TOX-09, October 2000


REFERENCES:

CODEN
REFERENCE
BECTA6 Bulletin of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1966-
BIOFX* BIOFAX Industrial Bio-Test Laboratories, Inc., Data Sheets. (1810 Frontage Rd., Northbrook, IL 60062)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
GTPPAF Gigiena Truda i Professional'naya Patologiya v Estonskoi SSR. Labor Hygiene and Occupational Pathology in the Estonian SSR. (Institut Eksperimental'noi i Klinicheskoi Meditsiny Ministerstva Zdravookhraneniya Estonskoi SSR, Tallinn, USSR) V.8- 1972-
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig, Ger. Dem. Rep.)
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967-
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.
VMDKAM Voprosy Meditsinskoi Khimii. Problems of Medical Chemistry. (V/O Me zhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1955-
WDZAEK Weisheng Dulixue Zazhi. Journal of Health Toxicology. (Weisheng Dulixue Zazhi Bianjibu, Dongdaqiao, Chaoyang Menwai, Beijing, Peop. Rep. China) V.1- 1987

Used as a disinfectant and fumigant

RTECS Compound Description:
   Tumorigen
   Mutagen
   Reproductive Effector
   Primary Irritant

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