The Registry of Toxic Effects of Chemical Substances

Coumarin, 3 - (alpha - acetonylbenzyl) - 4 - hydroxy -

RTECS #: GN4550000

CAS #: 81-81-2

UPDATE: November 2004 MW: 308.35 MF: C19H16O4


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. REPRODUCTIVE EFFECTS DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. (Phenyl - 1 acetyl - 2 ethyl) 3 - hydroxy - 4 coumarine (French)
  2. 1 - (4' - Hydroxy - 3' - coumarinyl) - 1 - phenyl - 3 - butanone
  3. 2H - 1 - Benzopyran - 2 - one, 4 - hydroxy - 3 - (3 - oxo - 1 - phenylbutyl) - (9CI)
  4. 3 - (1' - Phenyl - 2' - acetylethyl) - 4 - hydroxycoumarin
  5. 3 - (Acetonylbenzyl) - 4 - hydroxycoumarin
  6. 3 - (alpha - Acetonylbenzyl) - 4 - hydroxycoumarin
  7. 3 - (alpha - Phenyl - beta - acetylaethyl) - 4 - hydroxycumarin (German)
  8. 3 - (alpha - Phenyl - beta - acetylethyl) - 4 - hydroxycoumarin
  9. 4 - Hydroxy - 3 - (3 - oxo - 1 - fenyl - butyl) cumarine (Dutch)
  10. 4 - Hydroxy - 3 - (3 - oxo - 1 - phenyl - butyl) - cumarin (German)
  11. 4 - Hydroxy - 3 - (3 - oxo - 1 - phenylbutyl) - 2H - 1 - benzopyran - 2 - one
  12. 4 - Idrossi - 3 - (3 - oxo - 1 - fenil - butil) - cumarine (Italian)
  13. Arab Rat Deth
  14. Athrombin - K
  15. Athrombine - K
  16. Brumolin
  17. CO - Rax
  18. Compound 42
  19. Coumadin
  20. Coumafen
  21. Coumafene
  22. Coumarins
  23. Coumefene
  24. Cov - R - Tox
  25. Dethmor
  26. Dethnel
  27. Eastern states duocide
  28. Fasco fascrat powder
  29. Kumader
  30. Kumadu
  31. Kypfarin
  32. Latka 42 (Czech)
  33. Liqua - tox
  34. Mar - frin
  35. Martin's mar - frin
  36. Maveran
  37. Mouse pak
  1. RCRA waste number P001
  2. Rat & mice bait
  3. Rat - B - gon
  4. Rat - Gard
  5. Rat - Kill
  6. Rat - Mix
  7. Rat - O - cide #2
  8. Rat - Trol
  9. Rat - ola
  10. Ratorex
  11. Ratoxin
  12. Ratron
  13. Ratron G
  14. Rats - No - More
  15. Rattunal
  16. Ro - Deth
  17. Rodafarin
  18. Rodex blox
  19. Rough & ready mouse mix
  20. Solfarin
  21. Spray - trol brand roden - trol
  22. Temus W
  23. Twin light rat away
  24. Vampirinip II
  25. Vampirinip III
  26. W.A.R.F. 42
  27. Warf compound 42
  28. Warfarat
  29. Warfarin
  30. Warfarin (ACGIH:OSHA)
  31. Warfarin Q
  32. Warfarin plus
  33. Warfarine (French)
  34. Warficide
  35. Zoocoumarin (Russian)
  36. d - Con


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intramuscular
rabbit 		lowest published toxic dose: 10 mg/kg (8-28 day pregnant) Reproductive: Other developmental abnormalities

Reproductive: Effects on newborn: Stillbirth 		BLOOAW 36,623,1970
intramuscular
woman 		lowest published toxic dose: 12 mg/kg (27-31 week pregnant) Reproductive: Effects on embryo or fetus: Fetal death JMSHAO 26,562,1959
intravenous
mouse 		lowest published toxic dose: 240 mg/kg (2-3 day pregnant) Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea) CCPTAY 3,279,1971
oral
woman 		lowest published toxic dose: 28 mg/kg (1-20 week pregnant) Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)

Reproductive: Specific developmental abnormalities: Musculoskeletal system 		ADCHAK 55,139,1980
oral
woman 		lowest published toxic dose: 8,400 µg/kg (1-8 week pregnant) Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue) AJOGAH 127,191,1977
oral
woman 		lowest published toxic dose: 33,600 µg/kg (1-32 week pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Specific developmental abnormalities: Respiratory system

Reproductive: Effects on newborn: Physical 		AJOGAH 127,191,1977
unreported route
woman 		lowest published toxic dose: 6,450 µg/kg (27-33 week pregnant) Reproductive: Effects on embryo or fetus: Fetal death JMSHAO 26,562,1959


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lethal concentration (50 percent kill): 320 mg/m3 N/R GTPZAB 22(7),49,1978
intraperitoneal
mouse 		lethal dose (50 percent kill): 750 mg/kg N/R EJMCA5 30,531,1995
intraperitoneal
rat 		lowest published lethal dose: 420 mg/kg N/R TXAPA9 1,156,1959
intravenous
mouse 		lethal dose (50 percent kill): 165 mg/kg N/R 27ZIAQ -,274,1973
oral
cat 		lethal dose (50 percent kill): 6 mg/kg N/R DEVEAA 32,27,1978
oral
chicken 		lethal dose (50 percent kill): 942 mg/kg Peripheral Nerve and Sensation: Spastic paralysis with/without sensory change

Lung, Thorax, or Respiration: Dyspnea

Blood: Hemorrhage 		BECTA6 37,544,1986
oral
dog 		lethal dose (50 percent kill): 3 mg/kg N/R DEVEAA 43(255-256),20,1989
oral
guinea pig 		lethal dose (50 percent kill): 180 mg/kg N/R DEVEAA 32,27,1978
oral
human 		lowest published lethal dose: 6,667 µg/kg N/R YKYUA6 28,329,1977
oral
man 		lowest published toxic dose: 10,200 µg/kg Blood: Hemorrhage CMEP** -,1,1956
oral
mouse 		lethal dose (50 percent kill): 3 mg/kg N/R DEVEAA 43(255-256),20,1989
oral
pig 		lethal dose (50 percent kill): 1 mg/kg N/R DEVEAA 32,27,1978
oral
rat 		lethal dose (50 percent kill): 1,600 µg/kg N/R TXAPA9 11,327,1967
oral
rabbit 		lethal dose (50 percent kill): 800 mg/kg N/R DEVEAA 32,27,1978
oral
woman 		lowest published toxic dose: 250 µg/kg/2 day- intermittent Vascular: Structural changes in vessels AJEMEN 16,541,1998
oral
woman 		lowest published toxic dose: 15 mg/kg/21 week- intermittent Gastrointestinal: Ulceration or bleeding from small intestine

Blood: Change in clotting factors 		SMJOAV 75,242,1982
subcutaneous
mouse 		lowest published lethal dose: 800 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Food intake (animal) 		TIVSAI 58,122,1977
skin
rat 		lethal dose (50 percent kill): 1,400 mg/kg Eye: Chromodacryorrhea

Behavioral: Muscle weakness

Kidney, Ureter, and Bladder: Hematuria 		GTPZAB 22(7),49,1978
unreported route
mouse 		lethal dose (50 percent kill): 60 mg/kg N/R YKYUA6 30,397,1979
unreported route
rat 		lethal dose (50 percent kill): 50 mg/kg N/R YKYUA6 30,397,1979


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 16 mg/m3/4 hour/30 day- intermittent Blood: Normocytic anemia

Blood: Changes in erythrocyte (RBC) count

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		GTPZAB 22(7),49,1978
intraperitoneal
rat 		lowest published toxic dose: 10 mg/kg/2 day- intermittent Liver: Other changes

Blood: Change in clotting factors 		TXAPA9 180,186,2002
oral
dog 		lowest published toxic dose: 12 mg/kg/6 day- intermittent Blood: Change in clotting factors

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		YKYUA6 31,1385,1980
oral
human 		lowest published toxic dose: 4.35 mg/kg/15 day- intermittent Blood: Hemorrhage HBPTO* 1,60,2001
oral
mammal (species unspecified) 		lowest published toxic dose: 686 mg/kg/28 day- continuous Behavioral: Food intake (animal)

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		AECTCV 16,357,1987
oral
pig 		lowest published toxic dose: 1 mg/kg/5 day- intermittent Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases 		AJVRAH 43,1387,1982
oral
rat 		lowest published toxic dose: 11,250 µg/kg/90 day- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) TOLED5 1000(Suppl 1),141,1980
oral
rat 		lowest published toxic dose: 17,800 µg/kg/10 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field ESDBAK 32,251,1981
oral
rat 		lowest published toxic dose: 3.2 mg/kg/40 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field HBPTO* 1,60,2001
oral
rat 		lowest published toxic dose: 275.2 mg/kg/4 day- continuous Behavioral: Food intake (animal)

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		VHTODE 43,327,2001


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.1 mg/m3 DTLVS* TLV/BEI,2003
TOXICOLOGY REVIEW
TJADAB 66,127,2002
TOXICOLOGY REVIEW
BJOPAL 64,633,1980
TOXICOLOGY REVIEW
AJHGAG 30,104A,1978
TOXICOLOGY REVIEW
AJMEAZ 68,122,1980
TOXICOLOGY REVIEW
MUREAV 488,151,2001


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: RED Completed RBREV* -,156,1998
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 0.1 mg/m3 DTLVS* 3,279,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 0.1 mg/m3 CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 0.1 mg/m3 CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 0.1 mg/m3 CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 0.1 mg/m3 CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - ARAB Republic of Egypt time-weighted average 0.1 mg/m3, JAN1993
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.1 mg/m3, JAN1993
Occupational Exposure Limit - AUSTRIA MAK 0.1 mg/m3, JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 0.1 mg/m3, JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 0.1 mg/m3, JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 0.1 mg/m3, short term exposure limit 0.3 mg/m3, JAN1999
Occupational Exposure Limit - FRANCE VME 0.1 mg/m3, JAN1999
Occupational Exposure Limit - GERMANY MAK 0.5 mg/m3, JAN1999
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 0.1 mg/m3, 2003
Occupational Exposure Limit - NORWAY time-weighted average 0.1 mg/m3, JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 0.1 mg/m3, JAN1993
Occupational Exposure Limit - RUSSIA short term exposure limit 0.001 mg/m3, JAN1993
Occupational Exposure Limit - SWITZERLAND MAK- week 0.1 mg/m3, KZG- week 0.5 mg/m3, JAN1999
Occupational Exposure Limit - THAILAND time-weighted average 0.1 mg/m3, JAN1993
Occupational Exposure Limit - TURKEY time-weighted average 0.1 mg/m3, JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 0.1 mg/m3, short term exposure limit 0.3 mg/m3, SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 0.1 mg/m3
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 0.1 mg/m3


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO WARFARIN-air 10 hour time-weighted average 0.1 mg/m3 NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 76610;
Number of Industries 3;
Total Number of Facilities 2,535;
Number of Occupations 5;
Total Number of Employees Exposed 26,783
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 76610;
Number of Industries 6;
Total Number of Facilities 446;
Number of Occupations 8;
Total Number of Employees Exposed 6,131;
Total Number of Female Employees Exposed 1,874


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as an oral anticoagulant and as a rodenticide
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Warfarin, 5002


REFERENCES:

CODEN
REFERENCE
27ZIAQ "Drug Dosages in Laboratory Animals - A Handbook," Rev. ed., Barnes, C.D., and L.G. Eltherington, Berkeley, Univ. of California Press, 1973
ADCHAK Archives of Disease in Childhood. (British Medical Journal, POB 560B, Kennebunkport, ME 04046) V.1- 1926-
AECTCV Archives of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 070944) V.1- 1973-
AJEMEN American Journal of Emergency Medicine. (WB Saunders, Philadelphia, PA) V.1- 1983-
AJHGAG American Journal of Human Genetics. (Univ. of Chicago Press, Journals Div., POB 37005, Chicago, IL 60637) V.1- 1949-
AJMEAZ American Journal of Medicine. (Technical Pub., 875 Third Ave., New York, NY 10022) V.1- 1946-
AJOGAH American Journal of Obstetrics and Gynecology. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63146) V.1- 1920-
AJVRAH American Journal of Veterinary Research. (American Veterinary Medical Assoc., 930 N. Meacham Rd., Schaumburg, IL 60196) V.1- 1940-
BECTA6 Bulletin of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1966-
BJOPAL British Journal of Ophthalmology. (British Medical Journal, Box 560B, Kennebunkport, ME 04046) V.1- 1917-
BLOOAW Blood. (Grune & Stratton, Inc., 465 S. Lincoln Dr., Troy, MO 63379) V.1- 1946-
CCPTAY Contraception. (Geron-X, Inc., POB 1108, Los Altos, CA 94022) V.1- 1970-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CMEP** "Clinical Memoranda on Economic Poisons," U.S. Dept. HEW, Public Health Service, Communicable Disease Center, Atlanta, GA, 1956
DEVEAA Defense des Vegetaux. (Federation Nationale des Groupements de Protection des Cultures, 149, rue de Bercy, 75595 Paris Cedex, 12, France) V.1- 1947-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EJMCA5 European Journal of Medicinal Chemistry--Chimie Therapeutique. (Editions Scientifiques Elsevier, 29 rue Buffon, F-75005, Paris, France) V.9- 1974-
ESDBAK Eisei Dobutsu. Sanitary Zoology. (Nippon Eisei Dobutsu Gakkai, c/o Kokuritsu Yobo Eisei Kenkyusho Eisei Konchubo, 2-10-35 Kami-osaki, Shinagawa-ku, Tokyo 141, Japan) V.1- 1950-
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
HBPTO* Handbook of pesticide toxicology. Robert Krieger ed, Academic press, 2001
JMSHAO Journal of the Mount Sinai Hospital (New York). (New York, NY) V.1-36, 1934-69. For publisher information, see MSJMAZ.
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
SMJOAV Southern Medical Journal. (Southern Medical Assoc., POB 2446, Birmingham, AL 35205) V.1- 1908-
TIVSAI Trudy, VNIIVS. Transactions of the All-Union Scientific Research Institute of Veterinary Sanitation. (VNIIVS, Moscow, USSR) V.11- 1957-
TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
VHTODE Veterinary and Human Toxicology. (American College of Veterinary and Comparative Toxicology, Publication Office, Comparative Toxicology, Manhattan, KS 66506) V.19- 1977-
YKYUA6 Yakkyoku. Pharmacy. (Nanzando, 4-1-11, Yushima, Bunkyo-ku, Tokyo, Japan) V.1- 1950-

Used as an oral anticoagulant and as a rodenticide

RTECS Compound Description:
   Agricultural Chemical
   Reproductive Effector
   Human Data
   Natural Product

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